Conjugation of different immunogenic enterococcal vaccine target antigens leads to extended strain coverage [PDF]
, 2019 [Abstract] Enterococci have emerged as important nosocomial pathogens due to their resistance to the most commonly used antibiotics. Alternative treatments or prevention options are aimed at polysaccharides and surface-related proteins that play ...
Huebner, Johannes +7 more
core +2 more sources
Targeting the microbiota‐miRNA‐protease axis: A new therapeutic avenue in melanoma
The FEBS Journal, EarlyView.Modulation of extracellular matrix (ECM) turnover is central to melanoma progression and metastasis, driven largely by ECM proteases. This review highlights the epigenetic regulation of ECM proteases by microRNAs and their roles in melanoma growth, invasion, and immune modulation.
Elias N. Katsoulieris +2 more
wiley +1 more source
Scientific ReportsEnterococci, common hospital-acquired infections in immunocompromised patients, have garnered attention in clinical microbiology. To determine the clinical relevance of enterococci as food-borne pathogens, 116 fish, 90 vegetables, and 120 human diarrheal
Asmaa Gaber Mubarak +5 more
doaj +1 more source
An Enterococcus faecium Secreted Antigen, SagA, Exhibits Broad-Spectrum Binding to Extracellular Matrix Proteins and Appears Essential for E. faecium Growth [PDF]
Infection and Immunity, 2003 ABSTRACT A gene encoding a major secreted antigen, SagA, was identified in Enterococcus faecium by screening an E. faecium genomic expression library with sera from patients with E. faecium -associated endocarditis.
Teng Fang +4 more
openalex +4 more sources
Bacteriocins: Novel Solutions to Age Old Spore-Related Problems? [PDF]
, 2016 peer-reviewedBacteriocins are ribosomally synthesized antimicrobial peptides produced by bacteria, which have the ability to kill or inhibit other bacteria. Many bacteriocins are produced by food grade lactic acid bacteria (LAB).
Cotter, Paul D. +5 more
core +1 more source
Insertion Sequence–Driven Diversification Creates a Globally Dispersed Emerging Multiresistant Subspecies of E. faecium [PDF]
PLoS Pathogens, 2007 Enterococcus faecium, an ubiquous colonizer of humans and animals, has evolved in the last 15 years from an avirulent commensal to the third most frequently isolated nosocomial pathogen among intensive care unit patients in the United States. E. faecium combines multidrug resistance with the potential of horizontal resistance gene transfer to even more
Leavis, H.L. +5 more
openaire +4 more sources
Bacterial Extracellular Vesicles in the Pathogenesis and Treatment of Liver Diseases
Journal of Gastroenterology and Hepatology, EarlyView.Liver diseases are a major global health challenge, with current treatments inadequate. This review highlights the role of bacterial extracellular vesicles in liver inflammation, fibrosis, and metabolism. We also explore these from commensals and probiotics, their protective effects, and discuss research challenges and future therapeutic potential ...
Yakun Li +3 more
wiley +1 more source
The effect of a multispecies probiotic on the composition of the faecal microbiota and bowel habits in chronic obstructive pulmonary disease patients treated with antibiotics [PDF]
, 2009 Short-term antibiotic treatment profoundly affects the intestinal microbiota, which may lead to sustained changes in microbiota composition. Probiotics may restore such a disturbance.
Jonkers, D. +7 more
core +3 more sources
Salivary and Serum Cytokine Concentrations in Kidney Transplantation: A Prospective Study
Oral Diseases, EarlyView.ABSTRACT Background Kidney transplant recipients (KTRs) experience immune modulation, which may lead to graft rejection and other adverse outcomes. Although serum cytokines are well‐established systemic immune markers, the role of salivary biomarkers has never been reported in the literature.
Luciano Miziara +10 more
wiley +1 more source
Antimicrobial Resistance and Infection Control, 2020 Early in its evolution, Enterococcus faecium acquired traits that allowed it to become a successful nosocomial pathogen. E. faecium inherent tenacity to build resistance to antibiotics and environmental stressors that allows the species to thrive in ...
Xuewei Zhou +4 more
doaj +1 more source