Results 11 to 20 of about 6,362 (123)

CX3CR1 Modulates Migration of Resident Microglia Towards Cortical Laser-Induced Lesions. [PDF]

open access: yesGlia
CX3CR1 deficiency promotes microglial migration toward CNS injury. Proteomic profiling reveals altered RHO‐mediated cytoskeletal signaling, while in vivo two‐photon imaging demonstrates increased process extension, velocity, and accumulation of Cx3cr1‐deficient microglia at lesion sites. ABSTRACT Microglia are innate immune cells of the central nervous
Wagner J   +13 more
europepmc   +2 more sources

Wound Healing Patterns of PRF and PRGF Versus a Collagen-Based Substitute and Spontaneous Healing-A Randomised Controlled Clinical Trial Assessing Wound Closure of an Experimental, Standardised Palatal Defect. [PDF]

open access: yesJ Clin Periodontol
ABSTRACT Aims To evaluate wound‐healing progression among platelet‐rich fibrin (PRF), plasma rich in growth factors (PRGF), a collagen‐based wound dressing (CS = collagen substitute) and spontaneous healing (control), assessed by percentage of remaining open wound area and patient‐reported pain.
Bienz SP   +7 more
europepmc   +2 more sources

The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma

open access: yesCell Reports, 2018
Summary: Renal cell carcinoma (RCC) is not a single disease, but several histologically defined cancers with different genetic drivers, clinical courses, and therapeutic responses.
Christopher J. Ricketts   +769 more
doaj   +1 more source

Spatial Organization and Molecular Correlation of Tumor-Infiltrating Lymphocytes Using Deep Learning on Pathology Images

open access: yesCell Reports, 2018
Summary: Beyond sample curation and basic pathologic characterization, the digitized H&E-stained images of TCGA samples remain underutilized. To highlight this resource, we present mappings of tumor-infiltrating lymphocytes (TILs) based on H&E images ...
Joel Saltz   +740 more
doaj   +1 more source

Machine Learning Detects Pan-cancer Ras Pathway Activation in The Cancer Genome Atlas

open access: yesCell Reports, 2018
Summary: Precision oncology uses genomic evidence to match patients with treatment but often fails to identify all patients who may respond. The transcriptome of these “hidden responders” may reveal responsive molecular states. We describe and evaluate a
Gregory P. Way   +737 more
doaj   +1 more source

Integrated Genomic Analysis of the Ubiquitin Pathway across Cancer Types

open access: yesCell Reports, 2018
Summary: Protein ubiquitination is a dynamic and reversible process of adding single ubiquitin molecules or various ubiquitin chains to target proteins. Here, using multidimensional omic data of 9,125 tumor samples across 33 cancer types from The Cancer ...
Zhongqi Ge   +740 more
doaj   +1 more source

Somatic Mutational Landscape of Splicing Factor Genes and Their Functional Consequences across 33 Cancer Types

open access: yesCell Reports, 2018
Summary: Hotspot mutations in splicing factor genes have been recently reported at high frequency in hematological malignancies, suggesting the importance of RNA splicing in cancer.
Michael Seiler   +733 more
doaj   +1 more source

Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas

open access: yesCell Reports, 2018
Summary: DNA damage repair (DDR) pathways modulate cancer risk, progression, and therapeutic response. We systematically analyzed somatic alterations to provide a comprehensive view of DDR deficiency across 33 cancer types.
Theo A. Knijnenburg   +762 more
doaj   +1 more source

Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas

open access: yesCell Reports, 2018
Summary: This integrated, multiplatform PanCancer Atlas study co-mapped and identified distinguishing molecular features of squamous cell carcinomas (SCCs) from five sites associated with smoking and/or human papillomavirus (HPV). SCCs harbor 3q, 5p, and
Joshua D. Campbell   +784 more
doaj   +1 more source

Driver Fusions and Their Implications in the Development and Treatment of Human Cancers

open access: yesCell Reports, 2018
Summary: Gene fusions represent an important class of somatic alterations in cancer. We systematically investigated fusions in 9,624 tumors across 33 cancer types using multiple fusion calling tools.
Qingsong Gao   +746 more
doaj   +1 more source

Home - About - Disclaimer - Privacy