Results 21 to 30 of about 2,045,355 (222)

Somatic mutation of EZH2 (Y641) in Follicular and Diffuse Large B-cell Lymphomas of Germinal Center Origin

open access: yesNature Genetics, 2010
Follicular lymphoma (FL) and the GCB subtype of diffuse large B-cell lymphoma (DLBCL) derive from germinal center B cells. Targeted resequencing studies have revealed mutations in various genes encoding proteins in the NF-κB pathway that contribute to ...
Ryan D. Morin   +37 more
semanticscholar   +1 more source

Machine Learning Detects Pan-cancer Ras Pathway Activation in The Cancer Genome Atlas

open access: yesCell Reports, 2018
Summary: Precision oncology uses genomic evidence to match patients with treatment but often fails to identify all patients who may respond. The transcriptome of these “hidden responders” may reveal responsive molecular states. We describe and evaluate a
Gregory P. Way   +737 more
doaj   +1 more source

Integrated Genomic Analysis of the Ubiquitin Pathway across Cancer Types

open access: yesCell Reports, 2018
Summary: Protein ubiquitination is a dynamic and reversible process of adding single ubiquitin molecules or various ubiquitin chains to target proteins. Here, using multidimensional omic data of 9,125 tumor samples across 33 cancer types from The Cancer ...
Zhongqi Ge   +740 more
doaj   +1 more source

Somatic Mutational Landscape of Splicing Factor Genes and Their Functional Consequences across 33 Cancer Types

open access: yesCell Reports, 2018
Summary: Hotspot mutations in splicing factor genes have been recently reported at high frequency in hematological malignancies, suggesting the importance of RNA splicing in cancer.
Michael Seiler   +733 more
doaj   +1 more source

Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas

open access: yesCell Reports, 2018
Summary: DNA damage repair (DDR) pathways modulate cancer risk, progression, and therapeutic response. We systematically analyzed somatic alterations to provide a comprehensive view of DDR deficiency across 33 cancer types.
Theo A. Knijnenburg   +762 more
doaj   +1 more source

The Release 6 reference sequence of the Drosophila melanogaster genome

open access: yesGenome Research, 2015
Drosophila melanogaster plays an important role in molecular, genetic, and genomic studies of heredity, development, metabolism, behavior, and human disease.
R. Hoskins   +29 more
semanticscholar   +1 more source

Modeling Partially Reliable Information Sources: A General Approach Based on Dempster-Shafer Theory [PDF]

open access: yes, 2005
Combining testimonial reports from independent and partially reliable information sources is an important problem of uncertain reasoning. Within the framework of Dempster-Shafer theory, we propose a general model of partially reliable sources which ...
Hartmann, Stephan   +4 more
core   +1 more source

Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas

open access: yesCell Reports, 2018
Summary: This integrated, multiplatform PanCancer Atlas study co-mapped and identified distinguishing molecular features of squamous cell carcinomas (SCCs) from five sites associated with smoking and/or human papillomavirus (HPV). SCCs harbor 3q, 5p, and
Joshua D. Campbell   +784 more
doaj   +1 more source

Driver Fusions and Their Implications in the Development and Treatment of Human Cancers

open access: yesCell Reports, 2018
Summary: Gene fusions represent an important class of somatic alterations in cancer. We systematically investigated fusions in 9,624 tumors across 33 cancer types using multiple fusion calling tools.
Qingsong Gao   +746 more
doaj   +1 more source

PSYNDEX Tests Review für KA - Karriereanker

open access: yes, 2015
This is a PSYNDEX Tests Review of KA - Karriereanker. PSYNDEX Tests Reviews are written in German and describe and evaluate psychological and educational tests used in the German-speaking countries.
Karadere, Gülay
core   +1 more source

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