Results 21 to 30 of about 6,362 (123)

Molecular Characterization and Clinical Relevance of Metabolic Expression Subtypes in Human Cancers

open access: yesCell Reports, 2018
Summary: Metabolic reprogramming provides critical information for clinical oncology. Using molecular data of 9,125 patient samples from The Cancer Genome Atlas, we identified tumor subtypes in 33 cancer types based on mRNA expression patterns of seven ...
Xinxin Peng   +745 more
doaj   +1 more source

Aktivierung von Metallkomplexen durch Ultraschallwellen für eine gezielte Krebstherapie

open access: yesAngewandte Chemie, EarlyView.
Ultrasound enables non‐invasive activation of metal‐based therapeutics deep within tumors. Acoustic cavitation can drive sonodynamic reactive oxygen species generation or mechanochemical metal–ligand bond dissociation, enabling controlled release of bioactive payloads.
Félix Grosjean   +3 more
wiley   +1 more source

Mechanistische Diversität in der photoangeregten Radikal‐Redoxchemie: Eine kritische Evaluierung

open access: yesAngewandte Chemie, EarlyView.
Für viele prominente Beispiele der Photoredox‐Katalyse wird angenommen, dass sie über die Anregung einer offenschaligen („open‐shell“) Zwischenform des Katalysators ablaufen. Es wird jedoch intensiv darüber diskutiert, ob solche Mechanismen realistisch sind und, falls ja, wie genau sie ablaufen können.
Samuel J. Horsewill   +3 more
wiley   +1 more source

Von In‐Silico bis In‐Cerebro – Entwicklung des Orexinrezeptor Antagonisten „Photorexant“ zur Photomodulation In Vitro und im Gehirn der Maus

open access: yesAngewandte Chemie, EarlyView.
Durch einen strukturbasierten Designansatz wurden photoschaltbare Derivate des von der FDA zugelassenen Arzneistoffes Suvorexant entwickelt, gedockt, synthetisiert und pharmakologisch an den Orexin‐1‐ und 2‐Rezeptoren (OX1R und OX2R) charakterisiert.
Marcus Angermann   +10 more
wiley   +1 more source

Description of large, well‐preserved Enchodus specimens from the Bearpaw Formation of Alberta, Canada

open access: yesThe Anatomical Record, EarlyView.
Abstract Fishes of the genus Enchodus were abundant and cosmopolitan in the Late Cretaceous, but are primarily known from isolated remains in Canada. Four well‐preserved fish skulls were recovered in recent years from ammolite mines sampling the Bearpaw Formation of Southern Alberta, and are here referred to Enchodus petrosus Cope, 1874.
Luke E. Nelson   +2 more
wiley   +1 more source

Women's Leadership as a Driver of Small and Medium‐Sized Enterprises Sustainability and Green Transition: A Bibliometric and Systematic Review

open access: yesCorporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT This study combines a bibliometric analysis and a systematic literature review (SLR) to provide a comprehensive understanding of women's leadership and entrepreneurship within small and medium‐sized enterprises (SMEs) in the context of sustainability and the green transition.
Adriana Dima   +5 more
wiley   +1 more source

Extending the Cognitive Information Processing Approach: A Values‐Based Developmental Model for Adult Career Counseling

open access: yesJournal of Employment Counseling, EarlyView.
ABSTRACT Career development interventions for adults must address the complexity of contemporary work, including protean and boundaryless paths, multi‐contextual influences, and lifelong career management. The cognitive information processing (CIP) approach offers a robust framework for career decision‐making but was originally designed for ...
Hyung Joon Yoon
wiley   +1 more source

Validation of model predicting furcation involvement in newly crowned teeth—A 5‐year retrospective follow‐up

open access: yesJournal of Periodontology, EarlyView.
Abstract Background This study aimed to perform a prediction model validation for furcation involvement (FI) risk in molars receiving a new fixed prosthesis (FP) using a unique cohort assessed at three time points. Methods Following the Oral Health Statistical (OHStat) reporting guidelines, this cohort study examined 181 patients (203 molars) from 2018–
Khushboo Kalani   +5 more
wiley   +1 more source

Impaired but now diagnosable: Combining analytic frameworks for incorporating symptom weighting in the classification of full‐threshold and subthreshold posttraumatic stress disorder

open access: yesJournal of Traumatic Stress, EarlyView.
Abstract Individuals with subthreshold posttraumatic stress disorder (PTSD) often experience significant impairment yet face barriers to care (e.g., insurance denials and exclusion from clinical trials) due to strict Diagnostic and Statistical Manual of Mental Disorders (DSM)–based diagnostic criteria that rely entirely on symptom counts.
Krithika Prakash   +13 more
wiley   +1 more source

Knowledge Sharing in Organizations: A Review of the Recent Literature Partage des connaissances au sein des organisations : examen de la littérature récente

open access: yesAccounting Perspectives, EarlyView.
ABSTRACT The exchange and sharing of knowledge within organizations is a critical element of organizations' success. In this research, our objective is to synthesize and critically assess the knowledge‐sharing research published between 2006 and 2023. We address this objective in three ways.
Nicholle Kovach, Leslie Berger
wiley   +1 more source
biology general
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