Results 111 to 120 of about 309,262 (293)

QBP1 Peptide as a Potential Anti‐Amyloidogenic Therapy for Type 2 Diabetes: An In Vitro Study

Advanced Science, EarlyView.
The anti‐amyloidogenic peptide QBP1 effectively halts human islet amyloid polypeptide (hIAPP) aggregation, preventing the formation of toxic β‐structured intermediates. Through a combination of biophysical assays, molecular dynamics, and cell‐based studies, QBP1 is shown to preserve β‐cell viability and metabolic homeostasis, positioning it as a ...
María M. Tejero‐Ojeda, Ada Bernaus Vives, Michał Wojciechowski, Dinh Quoc Huy Pham, Mateusz Chwastyk, Mario Vallejo, Anna Novials, Douglas V. Laurents, Mariano Carrión‐Vázquez   +8 more
wiley   +1 more source

Unbalanced proportions of E1-226V and E1-226A provided in blood-meals to Ae. aegypti (AAPT) and Ae. albopictus (ALPROV). Ae. aegypti and Ae. albopictus were given an infectious blood-meal containing unbalanced proportions of two clones E1-A and E1-V isolated from the strains E1-226A and E1-226V, respectively.

, 2013
Two mixes were tested: one containing 1∶9 (E1-A:E1-V) and one containing a mix of 9∶1 (E1-A:E1-V). At day 7 post-infection, dissemination (A) and transmission (B) were examined by estimating the proportion of E1-V in wings and saliva, respectively, of ...
Anna-Bella Failloux (219978), Laurence Mousson (261612), François Rougeon (84067), Camilo Arias-Goeta (291814)   +3 more
core   +1 more source

ERK‐Mediated Phosphorylation of YAP Defines a Noncanonical FGF Signaling Mechanism in Stem Cells

Advanced Science, EarlyView.
With a powerful combination of in vivo, ex vivo, and in vitro models, the authors highlight a novel FGF‐ERK signaling regulation of YAP at the S128 site in neural crest‐derived stem cells. This study opens exciting new directions in stem cell biology and craniofacial biology, paving the way for potential innovations in the treatment of craniofacial ...
Xiaolei Zhao, Shannon Erhardt, Li Tang, Xiaotong Chen, Stephen M Farmer, Zixiu Cheng, Wen Chen, Ella Ziyuan Lu, Kihan Sung, Chang‐Ru Tsai, Mingjie Zheng, Sheng Zhang, Yang Liu, Jianxin Wang, Min Li, James F Martin, Jun Wang   +16 more
wiley   +1 more source

SOME ISSUES OF CRITICAL THINKING DEVELOPMENT IN THE PROCESS OF MASTERING MANAGEMENT [PDF]

ეკონომიკური პროფილი
In the modern world, where information and technology are developing rapidly, the educational system faces new challenges and opportunities. Education is no longer a static process.
Nana Lukhutashvili
doaj   +1 more source

THE E1 - E1 + Δ1 TRANSITIONS IN BULK GROWN AND IN IMPLANTED LASER ANNEALED HEAVILY DOPED GERMANIUM : LUMINESCENCE

, 1983
Nous présentons des mesures de luminescence visible excitée par un laser continu et liée aux transitions directes E1, E1 + Δ1, dans Ge type n avec Ne >≈ 1018 cm-3.
M. Cardona, J. Wagner, A. Axmann, G. Contreras, A. Compaan   +4 more
core   +1 more source

A Rare Allele of ST5 From Wild Rice Enhances Salt Tolerance in Rice

Advanced Science, EarlyView.
A novel salt‐tolerance gene ST5W, characterized by a unique 36‐bp promoter insertion, is found exclusively in a small subset of Oryza rufipogon and is absent in cultivated rice. Field trials confirm ST5W significantly enhances rice yield across diverse genetic backgrounds under saline conditions.
Meng Xing, Jingfen Huang, Qiaoling Yuan, Ziyi Yang, Yanyan Wang, Mingchao Zhao, Yamin Nie, Rui Xu, Hongge Qian, Wenxi Chen, Qiaoling Zhang, Qi Du, Leiyue Geng, Yapeng Li, Ziyi Chen, Shizhuang Wang, Like Lou, Haiyuan Peng, Chongke Zheng, Xianzhi Xie, Xiaoming Zheng, Lifang Zhang, Lianguang Shang, Jiaqiang Sun, Qian Qian, Qingwen Yang, Weihua Qiao   +26 more
wiley   +1 more source

Grado en Derecho (E1)

, 2016
Grado en Derecho ...
Pontificia Comillas, Universidad
core  

In (A), EMSA assay with probes E1-B (left panel) and E1-C (right panel) and nuclear extracts from AML14

, 2011
Copyright information:Taken from "Analysis of the CCR3 promoter reveals a regulatory region in exon 1 that binds GATA-1"BMC Immunology 2005;6():7-7.Published online 4 Apr 2005PMCID:PMC1080127.Copyright © 2005 Zimmermann et al; licensee BioMed Central Ltd.
Marc E Rothenberg (27127), Jessica L Colyer (27125), Laura E Koch (27126), Nives Zimmermann (27124)   +3 more
core   +1 more source

Cryo‐EM Structure Guided Engineering of Botulinum Neurotoxin A With Advanced Receptor Binding Affinity and Therapeutical Benefits

Advanced Science, EarlyView.
The butterfly unfolded wing in an open form structure of botulinum neurotoxin type A (BoNT/A) at physiological‐state was confirmed at 2.85 Å resolution by cryo‐electron microscopy (cryo‐EM). Structure‐guided protein engineering significantly enhanced the receptor‐binding affinity, therapeutic efficacy, and safety of the engineered toxin variants ...
Wenrui Wang, Zhaxi Zerang, Linjin You, Ziye Liu, Rong Nie, Fuwei Qi, Fenfen Gao, Chengmu Zhao, Wantong Ma, Jinghan He, Xiaoru Wang, Shanquan Wu, Bo Liu, Xinyao Liu, Dongsheng Lei, Dejuan Zhi, Dongsheng Wang   +16 more
wiley   +1 more source

Social deprivation and severe cervicofacial abscess: A retrospective review of patients presenting to a tertiary oral and maxillofacial surgery unit

Advances in Oral and Maxillofacial Surgery
Background: Severe cervicofacial abscesses require emergency incision and drainage under general anaesthetic to avoid life-threatening sequelae. There is a well-described association between dental disease and socioeconomic status (SES), and most ...
Clarissa Hjalmarsson, Mark Cairns, William Rohde, Domniki Chatzopoulou, Simon Holmes   +4 more
doaj   +1 more source