Results 121 to 130 of about 309,262 (293)

Highly Active Cu14 Cluster Precisely Activates Autophagy Inhibitor to Amplify Cuproptosis Immunotherapy

Advanced Science, EarlyView.
An atomically precise Cu14 cluster‐mediated bond scission reaction pioneers the amplification of the antitumor immune response via synergetic cuproptosis‐associated immunogenic cell death induction and in situ autophagy blockade. ABSTRACT Transition metal‐mediated cleavage mechanisms have emerged as an effective means to mitigate the off‐target ...
Qiu‐Xu Zang, Wei‐Tong Chen, Yu‐Ying Shen, Zhao‐Yang Wang, Kai Li, Xueli Zhao, Yanjuan Sang, Xiaoyuan Chen, Shuang‐Quan Zang   +8 more
wiley   +1 more source

Figure e1.

, 2015
Flowchart of study population. Figure e2. Distribution of propensity scores for the entire study population. Figure e3. Distribution of propensity scores for the cohort of patients surviving until hospital discharge. Table e1. Codes used to identify the study population, comorbidity, use of medicine, and in-hospital procedures. Table e2.
Lauridsen, Marie, Gammelager, Henrik, Schmidt, Morten, Rasmussen, Thomas, Shaw, Richard, BøTker, Hans, SøRensen, Henrik, Christiansen, Christian   +7 more
openaire   +1 more source

HPV E1 up-regulates replication-related biochemistries of AAV Rep78

, 2010
Human papillomavirus type 16 (HPV) E1 protein provides helper function for the adeno-associated virus type 2 (AAV) life cycle. E1 is the replication protein of HPV, analogous to AAV Rep78, but without the endonuclease/covalent attachment activity of ...
Hermonat, Paul L., Cao, Maohua, Liu, Yong, Bandyopadhyay, Sarmistha   +3 more
core   +1 more source

From Pores to Pavement: Advanced Modeling of Aluminosilicates for Scalable Carbon Capture in Concrete

Advanced Science, EarlyView.
This study presents a transferable modeling framework for carbon capture using aluminosilicates, integrating Universal Isotherm Modeling with experimental data. It reveals how ultramicropores, alumina content, and amine functionalization influence CO2 adsorption energetics.
Pooja Anil Kumar Nair, Jéssica de O. N. Ribeiro, Murilo Daniel de Mello Innocentini, Kevin Paine, Juliana Calabria‐Holley   +4 more
wiley   +1 more source

Largazole and its derivatives selectively inhibit ubiquitin activating enzyme (e1).

, 2012
Protein ubiquitination plays an important role in the regulation of almost every aspect of eukaryotic cellular function; therefore, its destabilization is often observed in most human diseases and cancers.
Dana Ungermannova, Seth J Parker, Xuedong Liu, Ungermannova Dana, Parker Seth J., Robert D Kuchta, Andrew J Phillips, Quade Bettina, Bettina Quade, Nasveschuk Christopher G., Wang Wei, Zhang Gan, Christopher G Nasveschuk, Kuchta Robert D., Gan Zhang, Wei Wang, Phillips Andrew J., Liu Xuedong   +17 more
core   +1 more source

Mitochondria and Neuromast Tagging With Fluorescent Gallium‐Triapine Analogues: In Cellulo MP FLIM and Zebrafish Live Imaging

Advanced Science, EarlyView.
Fluorescent BODIPY‐conjugated thiosemicarbazone ligands and their Ga(III), In(III), and Fe(III) complexes, inspired by Triapine, are developed as theranostic agents. Multiphoton FLIM and confocal microscopy in cancer cells and zebrafish reveal real‐time uptake, mitochondrial localisation, and whilst spectroscopic assays indicated preserved complex ...
Megan J. Green, Michael W. Jones, Merissa Saleem, Haobo Ge, Melita Tvardauskaite, Julia Dudzic, Fernando Cortezon‐Tamarit, Rory L. Arrowsmith, Charareh Pourzand, Gabriele Kociock‐Kohn, Nicholas H. Rees, Jonathan R. Dilworth, Stephen Faulkner, Stanley W. Botchway, David Gurevich, Sofia I. Pascu   +15 more
wiley   +1 more source

NUP85 Mediates Endoplasmic Reticulum Stress through the USP47/ASK1 Signaling Pathway to Regulate the Progression of Liver Fibrosis

Advanced Science, EarlyView.
In the present study, we have demonstrated that the NUP85‐USP47‐ASK1 signaling pathway may have regulated the progression of liver fibrosis through modulating ERS. Additionally, we have developed a CREKA‐coupled liposome to target delivery of MV, a pharmacological inhibitor of NUP85, to activated HSCs, thereby attenuating liver fibrosis. ABSTRACT Liver
Dashuai Yang, Haoran Yang, Linxin Pan, Chang Tian, Fucheng Zuo, Shilei Huang, Xianrui Li, Ming Chen, Cheng Qian, Jie Wang, Zhaolin Chen, Tao Xu   +11 more
wiley   +1 more source

Ecological Adaptation Mechanisms Underlying Successful Plant Reproduction

Advanced Science, EarlyView.
During floral induction, various environmental and endogenous signals converge to regulate the florigen protein, which is transported from leaves to the SAM to initiate flowering. Within the SAM, a complex network of receptor kinases and small peptides orchestrates floral development with high spatiotemporal precision.
Hang Zhao, Shenghui Huo, Yue Xing, Shuxin Zhang, Guilin Li, Yihui Liu, Chongyang Jin, Fuguang Li, Xiaoyang Ge   +8 more
wiley   +1 more source

Analyzing the Precise Point Positioning Performance of Different Dual-Frequency Ionospheric-Free Combinations with BDS-3 and Galileo

Atmosphere
The BeiDou global navigation satellite system (BDS-3) and Galileo systems both broadcast satellite signals on five frequencies, which can form many observation combinations with dual-frequency ionospheric-free (DFIF) precise point positioning (PPP). This
Xingli Sun, Zhan Shu, Jinjie Yao
doaj   +1 more source

Alignment of e1-ba3 with other known E1 mutations.

, 2015
The SNP mutation site for e1-as, e1-fs are marked by black boxes; and the 5 bp mutation is marked with a red box. The bipartite nuclear localization sites are marked by black dashed line. The B3-like domain is also indicated with a dashed red line.
Yupeng Zhang (632467), Hongmei Qiu (564530), Hongyan Wu (302636), Xingzheng Zhang (524631), Yaying Wang (318383), Jiayin Yang (142533), Hong Zhai (524629), Shixiang Lü (524630), Tingting Cui (564531), Zhengjun Xia (524633), Guang Yang (154978)   +10 more
core   +1 more source