Results 181 to 190 of about 176,319 (351)

Unraveling the role of Cullin3 of E3 ubiquitin ligase in salt stress tolerance via proteomics. [PDF]

BMC Plant Biol
Herwibawa B, Lekklar C, Roytrakul S, Ito T, Chadchawan S, Buaboocha T.   +5 more
europepmc   +1 more source

eLife Assessment: The E3 ubiquitin ligase RNF220 maintains hindbrain Hox expression patterns through regulation of WDR5 stability

Paschalis Kratsios
openalex   +1 more source

Bioorthogonal Sonodynamic Plug‐and‐Play Targeting Chimeras (SDPTAC) for Precise Targeted Protein Degradation

Advanced Science, EarlyView.
Bioorthogonal SDPTAC harnesses US‐responsive Ce6‐TCO and Tz ligands via IEDDA click chemistry to assemble degraders in situ, generating ROS that selectively eliminate nuclear, cytosolic, and membrane proteins, thereby suppressing deep‐seated tumors in vivo.
Yuhan Bao, Yaojin Zhu, Xinhao Wei, Yuxin Fang, Jiayi Zhu, Fei Gao, Guoqiang Dong, Shipeng He, Chunquan Sheng   +8 more
wiley   +1 more source

The Putative E3 Ubiquitin Ligase TEX1 Is Required for Nuclear Biology and Developmental Progression of Plasmodium berghei in the Liver. [PDF]

Cells
Schmid M, Golomingi R, Franke-Fayard B, Caldelari R, Rehmann R, Roques M, Heussler VT.   +6 more
europepmc   +1 more source

E3 Ubiquitin-Protein Ligase UBR5 [PDF]

, 2020
openaire   +1 more source

Dual Aptamers‐Based SETDB1 PROTACs as Effective Anti‐Tumor Strategies for Breast Cancer

Advanced Science, EarlyView.
This study establishes dual‐aptamer PROTACs targeting SETDB1 using a SETDB1‐specific aptamer conjugated to AS1411. The designed PROTACs penetrate cells, recruit MDM2 to degrade SETDB1, and inhibit cancer cell proliferation and migration. Remarkably, they also overcome tamoxifen resistance and enhance CD8+ T cell cytotoxicity, suppressing tumor growth ...
Yanxuan Guo, Yingge Lv, Shuyu Huang, Chang Liu, Yan Ouyang, Bei Lan, Chenghao Xuan   +6 more
wiley   +1 more source

Regulation of PD-L1 Protein Expression by the E3 Ubiquitin Ligase GP78. [PDF]

Curr Issues Mol Biol
Chatterjee M, Pimentel JM, Zhou JY, Mugunamalwaththa T, Yang Z, Raz A, Wu GS.   +6 more
europepmc   +1 more source

E3 Ubiquitin-Protein Ligase RNF43 [PDF]

, 2020
openaire   +1 more source

Repertoire of plant RING E3 ubiquitin ligases revisited: New groups counting gene families and single genes [PDF]

, 2018
Domingo Jiménez-López, Francisco Muñóz-Belman, Juan Manuel González-Prieto, Victor Aguilar‐Hernández, Plinio Guzmán   +4 more
openalex   +1 more source

TRIM40 Drives Pathological Cardiac Hypertrophy and Heart Failure via Ubiquitination of PKN2

Advanced Science, EarlyView.
This study identifies the E3 ligase TRIM40 as a key driver of pathological cardiac hypertrophy. TRIM40 binds PKN2 via its B‐box domain and, through its C29‐dependent catalytic activity, mediates K63‐linked ubiquitination of PKN2. This modification enhances PKN2 phosphorylation at Ser815, thereby driving hypertrophy.
Risheng Zhao, Xiaoli Cui, Huizhu Du, Zhuoqun Wang, Chang Liu, Linxin Zhang, Jianing Qi, Di Yang, Hui Yu, Shuang Yan, Wei Liu, Haiming Sun, Mengyang Wang   +12 more
wiley   +1 more source