Results 241 to 250 of about 149,506 (292)

Targeting eEF1A1 With Baicalein to Block eEF1A1/Prdx4 Interaction for Treating Sepsis‐Mediated Lung Injury

Exploration, EarlyView.
Targeting eEF1A1 with baicalein disrupts the eEF1A1‐Prdx4 interaction to prevent RNF14‐mediated ubiquitination and degradation of Prdx4. This stabilizes Prdx4 to suppress NF‐κB, thereby alleviating sepsis‐induced acute lung injury. ABSTRACT Sepsis is a systemic inflammatory response syndrome triggered by an uncontrolled host response to infection ...
Jing Chang, Hui‐Lin Zhang, Qi‐Meng Zhu, Si‐Wen Hui, Xin‐Rong Xu, Mahmood Brobbey Oppong, Yan‐Li Feng, Juan Zhang, Cheng‐Peng Sun, Feng Qiu   +9 more
wiley   +1 more source

Radiation-induced nuclear translocation of NPRL2 hijacks E3 ubiquitin ligases to enhance DNA repair <i>via</i> the AMPK/WDR24 axis, contributing to CRC radioresistance. [PDF]

Acta Pharm Sin B
Wang X, Zhao Y, Yang X, Liu T, Zhou W, Niu S, Jin M, Chen Y, Liu RY, Bao Y, Yue X.   +10 more
europepmc   +1 more source

From Temperature Fluctuations to Precise Control: Biochemical Techniques Integrated Digital‐Intelligent Technology for Vegetable Preservation

Future Postharvest and Food, EarlyView.
The physiological effects and molecular responses of postharvest vegetables to temperature fluctuations, and multi‐technology integration strategies for maintaining postharvest vegetable quality. ABSTRACT Vegetables are indispensable agricultural products in the human diet. With the continuous growth of vegetable production and consumption, postharvest
Shuaishuai Dai, Kuo Chen, Xing Xing, Liqun Ma, Hongliang Zhu   +4 more
wiley   +1 more source

Redirecting E3 ubiquitin ligases for targeted protein degradation with heterologous recognition domains. [PDF]

J Biol Chem
Yang H, Zheng G, Li GY, Alshaye A, Orkin SH.   +4 more
europepmc   +1 more source

Chromatin-associated cullin-RING E3 ubiquitin ligases: keeping transcriptionally active NF-κB in check. [PDF]

Front Immunol
Gong M, Luo J, Liang Q, Liu Y, Zheng Y, Yang XD.   +5 more
europepmc   +1 more source

E3 Ubiquitin ligases Cbl-b and c-Cbl maintain the homeostasis of macrophages by regulating the M-CSF/M-CSFR signaling axis. [PDF]

Cell Death Dis
Xu F, Tan C, Tang K, Qiao G, Shao Y, Li X, Zhou J, Zhu P, Wu M, Cai J, Gao X, Wang Y, Huang B, Wang W, Xia T, Xu X, Li J, Chen Z, Shi Y, Hao C, Yang Y, Zhang J.   +21 more
europepmc   +1 more source

<i>De Novo</i>-Designed APC/C Inhibitors Provide a Rationale for Targeting RING-Type E3 Ubiquitin Ligases. [PDF]

J Med Chem
Ruiz-Gómez G, Uvizl A, Bakos G, Leung JK, Pisabarro MT, Mansfeld J.   +5 more
europepmc   +1 more source

High-Throughput Discovery of Substrate Peptide Sequences for E3 Ubiquitin Ligases Using a cDNA Display Method. [PDF]

Chembiochem
Tamagawa K, Campbell RE, Terai T.
europepmc   +1 more source

Human E3 ubiquitin ligases: accelerators and brakes for SARS-CoV-2 infection. [PDF]

Biochem Soc Trans
Pellman J, Goldstein A, Słabicki M.
europepmc   +1 more source