Results 261 to 270 of about 68,518 (300)

RBR E3 ubiquitin ligases in tumorigenesis

Seminars in Cancer Biology, 2020
RING-in-between-RING (RBR) E3 ligases are one class of E3 ligases that is characterized by the unique RING-HECT hybrid mechanism to function with E2s to transfer ubiquitin to target proteins for degradation. Emerging evidence has demonstrated that RBR E3 ligases play essential roles in neurodegenerative diseases, infection, inflammation and cancer ...
Peter, Wang, Xiaoming, Dai, Wenxiao, Jiang, Yuyun, Li, Wenyi, Wei   +4 more
openaire   +2 more sources

E3 ubiquitin ligases for MHC molecules

Current Opinion in Immunology, 2009
Recently, novel E3 ubiquitin ligases that target MHC molecules for lysosomal degradation have been discovered by several groups. All these E3s are membrane-bound and possess a variant type RING domain, termed the RING-CH or RING variant (RINGv) domain. They belong to a new E3 family designated Modulator of Immune Recognition (MIR), based on the name of
Satoshi, Ishido, Eiji, Goto, Yohei, Matsuki, Mari, Ohmura-Hoshino   +3 more
openaire   +2 more sources

HECT-Type E3 Ubiquitin Ligases in Cancer

Trends in Biochemical Sciences, 2019
Ubiquitination, a post-translational modification that involves a covalent attachment of ubiquitin to a protein substrate, is essential for cellular homeostatic maintenance. At the end of a three-enzyme cascade, E3 ubiquitin ligases (E3s) recruit substrates and promote or directly catalyze ubiquitin transfer to targets.
Francesca Bernassola, Giovanni Chillemi, Gerry Melino   +2 more
openaire   +4 more sources

Pseudophosphatase as E3 ubiquitin ligase inhibitor

Science Signaling, 2017
The pseudophosphatase STYX prevents the substrate recognition subunit FBXW7 from binding the catalytic E3 ubiquitin ligase complex.
openaire   +2 more sources

Ubiquitin ligases: guardians of mammalian development

Nature Reviews Molecular Cell Biology, 2022
David A Cruz Walma, Zhuoyao Chen, Alex N Bullock   +2 more
exaly  

E3-Ubiquitin Ligase

2011
openaire   +2 more sources

E3 Ubiquitin Ligases

2012
Uwe Proske, David L. Morgan, Tamara Hew-Butler, Kevin G. Keenan, Roger M. Enoka, Sebastian Sixt, Josef Niebauer, John A. Hawley, Martin J. Gibala, Kathryn H. Myburgh, C. Capelli, P. Zamparo, Jie Kang, Herbert Löllgen, Ruth Löllgen, Wolfgang Jelkmann, Christopher B. Scott, Ioannis Smyrnias, Martin D. Bootman, H. Llewelyn Roderick, Jonathan N. Myers, Peter H. Brubaker, Kai-Håkon Carlsen, Michael Kjær, Marc Sim, Peter Peeling, Brian Dawson, Debbie Trinder   +27 more
openaire   +1 more source

RBR E3 Ubiquitin Ligases

2016
Steven A. Beasley, Yaya Wang, Donald E. Spratt   +2 more
openaire   +1 more source

Structural insights into the catalysis and regulation of E3 ubiquitin ligases

Nature Reviews Molecular Cell Biology, 2016
Lori Buetow, Danny T Huang
exaly  

Function and regulation of cullin–RING ubiquitin ligases

Nature Reviews Molecular Cell Biology, 2005
Raymond J Deshaies
exaly