Results 251 to 260 of about 68,518 (300)

Coenzyme A mitigates cystine‐deprivation‐induced ferroptosis by suppressing the iron‐starvation response

The FEBS Journal, EarlyView.
Cystine (Cys2) deprivation in pancreatic cancer cells induces oxidative stress that destabilizes cytosolic iron–sulfur cluster (ISC) proteins, triggering an iron‐regulatory protein (IRP)‐mediated iron‐starvation response (ISR). This leads to increased iron uptake (via TFRC), an expanded labile iron pool, and ferroptosis.
Mingjun Tan, Yunzhan Li, Lei Sang, Min Wang, Qin Li, Zekun Li, Dongxiao Sun, Xiuchao Wang, Shengyu Yang   +8 more
wiley   +1 more source

Lock, relax, load, and shoot: a molecular perspective on Nedd4 regulation

The FEBS Journal, EarlyView.
Structural basis of inactive and active states of the Nedd4 HECT E3 ligase subfamily, following a ‘lock, relax, load, and shoot’ mechanism. In the locked, autoinhibited state, intramolecular domain interactions restrain the HECT domain. Relaxation releases these restraints, allowing loading of ubiquitin onto the catalytic cysteine, followed by the ...
Masa Janosev, Tomas Obsil, Veronika Obsilova   +2 more
wiley   +1 more source

Rethinking the role of HIF in hepatocellular carcinoma

The FEBS Journal, EarlyView.
Tumor hypoxia is a hallmark of cancer driving disease, in part through activation of hypoxia‐inducible factors (HIFs). While HIF‐1α is classically understood as a hypoxia‐responsive transcription factor, its role under normoxic conditions in cells is less clear.
Niall S. Kenneth, Michael Batie, Sonia Rocha   +2 more
wiley   +1 more source

Friend or foe? Reciprocal regulation between E3 ubiquitin ligases and deubiquitinases. [PDF]

Biochem Soc Trans
Bolhuis DL, Emanuele MJ, Brown NG.
europepmc   +1 more source

MARCH family E3 ubiquitin ligases selectively target and degrade cadherin family proteins. [PDF]

PLoS One
Seo T, Lowery AM, Xu H, Giang W, Troyanovsky SM, Vincent PA, Kowalczyk AP.   +6 more
europepmc   +1 more source

Deciphering the mechanism of E3 ubiquitin ligases in plant responses to abiotic and biotic stresses and perspectives on PROTACs for crop resistance. [PDF]

Plant Biotechnol J
Su Y, Ngea GLN, Wang K, Lu Y, Godana EA, Ackah M, Yang Q, Zhang H.   +7 more
europepmc   +1 more source

Regulation of the water channel aquaporin-2 by cullin E3 ubiquitin ligases.

Am J Physiol Renal Physiol
Murali SK, McCormick JA, Fenton RA.
europepmc   +1 more source

Some of the next articles are maybe not open access.

Related searches:

E3 ubiquitin ligases

Essays in Biochemistry, 2005
The selectivity of the ubiquitin–26 S proteasome system (UPS) for a particular substrate protein relies on the interaction between a ubiquitin-conjugating enzyme (E2, of which a cell contains relatively few) and a ubiquitin–protein ligase (E3, of which there are possibly hundreds).
Helen C, Ardley, Philip A, Robinson
openaire   +2 more sources