Differential localization of HPV16 E6 splice products with E6-associated protein [PDF]
Virology Journal, 2005 High-risk Human Papillomavirus (HPV) is the etiological agent associated with the majority of anogenital cancers. The primary HPV oncogenes, E6 and E7, undergo a complex splicing program resulting in protein products whose purpose is not fully understood.
Ponglikitmongkol Mathurose +3 more
doaj +2 more sources
The Role of E6 Spliced Isoforms (E6*) in Human Papillomavirus-Induced Carcinogenesis
Viruses, 2018 Persistent infections with High Risk Human Papillomaviruses (HR-HPVs) are the main cause of cervical cancer development. The E6 and E7 oncoproteins of HR-HPVs are derived from a polycistronic pre-mRNA transcribed from an HPV early promoter.
Leslie Olmedo-Nieva +3 more
doaj +2 more sources
Drug Design, Development and Therapy, 2018 Peng Zhang, Zhongyu Ren, Zhiqiang Chen, Jinyong Zhu, Jing Liang, Rujia Liao, Jian Wen Research Center for Nervous System Diseases, The Affiliated Hospital of Guilin Medical University, Guilin Medical University, Guilin, Guangxi, People’s Republic ...
Zhang P +6 more
doaj +1 more source
, 2021 Human papillomaviruses (HPV) are a major cause of malignancy worldwide, contributing to ~5% of all human cancers including almost all cases of cervical cancer and a growing number of ano-genital and oral cancers.
JA Scarth (17027322) +6 more
core +4 more sources
The E6E7 oncoproteins of cutaneous human papillomavirus type 38 interfere with the interferon pathway [PDF]
, 2008 Non-melanoma skin cancer is the most frequent malignancy in Caucasian populations. Evidence suggests the involvement of cutaneous Human Papillomavirus (HPV) of the genus beta () in this disease. The ability of E6 and E7 of mucosal HPV to promote cellular
Tommasino, M. +13 more
core +1 more source
Solution Structure Analysis of the HPV16 E6 Oncoprotein Reveals a Self-Association Mechanism Required for E6-Mediated Degradation of p53 [PDF]
, 2012 SummaryThe viral oncoprotein E6 is an essential factor for cervical cancers induced by “high-risk” mucosal HPV. Among other oncogenic activities, E6 recruits the ubiquitin ligase E6AP to promote the ubiquitination and subsequent proteasomal degradation ...
Kieffer, B. (Bruno) +16 more
core +1 more source
Cell cycle control and its modulation in HPV infected cells [PDF]
, 2010 A key effect of human papillomavirus (HPV) infection is to disrupt the normal cell cycle in order to subvert the cellular DNA replication machinery. Morphologically, condylomata induced by high and low risk HPV types cannot be distinguished and many ...
Lyman, Rachel C.
core +2 more sources
Structural dynamics of the E6AP/UBE3A-E6-p53 enzyme-substrate complex [PDF]
, 2018 <p>Deregulation of the ubiquitin ligase E6AP is causally linked to the development of human disease, including cervical cancer. In complex with the E6 oncoprotein of human papillomaviruses, E6AP targets the tumor suppressor p53 for degradation ...
Scheffner, M +39 more
core +1 more source
The role of human papillomavirus (HPV) E6 proteins as a risk factor for oesophageal cancer [PDF]
, 2007 Includes bibliographical references (leaves 74-83).Oesophageal squamous cell carcinoma (OSCC) is a major cancer in South Africa, affecting mainly black males.
Ross-Innes, Caryn Sarah
core +1 more source
International Environment: Recovery and Resolution Regimes as the Pillar of the Banking Union
Naše Gospodarstvo, 2019 The purpose of the article is to present the possible regimes of bank resolution in the euro system and to highlight open questions concerning additional capital buffers and the valuation of assets according to the Bank Recovery and Resolution Directive (
Festić Mejra
doaj +1 more source