Results 31 to 40 of about 129,891 (225)
Visualising the Truth: A Composite Evaluation Framework for Score-Based Predictive Model Selection
BioMedInformaticsBackground: The selection of machine learning (ML) models in the biomedical sciences often relies on global performance metrics. When these metrics are closely clustered among candidate models, identifying the most suitable model for real-world ...
Uraquitan Lima Filho +2 more
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Nuclear Materials and Energy, 2017 Interactions of Tungsten (W), Molybdenum (Mo), and Beryllium (Be) vapors with a steady-state plasma were studied by the PISCES-B liner plasma experiments as well as Particle-In-Cell (PIC) simulations for the understanding of vapor-shielding phenomena ...
K. Ibano +7 more
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Intracellular Analysis of the Interaction between the Human Papillomavirus Type 16 E6 Oncoprotein and Inhibitory Peptides. [PDF]
PLoS ONE, 2015 Oncogenic types of human papillomaviruses (HPVs) cause cervical cancer and other malignancies in humans. The HPV E6 oncoprotein is considered to be an attractive therapeutic target since its inhibition can lead to the apoptotic cell death of HPV-positive
Christina Stutz +9 more
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Papillomavirus E6 oncoproteins [PDF]
, 2013 Papillomaviruses induce benign and malignant epithelial tumors, and the viral E6 oncoprotein is essential for full transformation. E6 contributes to transformation by associating with cellular proteins, docking on specific acidic LXXLL peptide motifs ...
Vande Pol, Scott B. +1 more
core +1 more source
Copper in Chile - When the Resource “Outside” Becomes a Blessing
International Journal of Management and Economics, 2014 The article aims at explaining how a small opened economy can effectively deal with a resource abundance problem. The thesis of the essay is a statement that Chile has been able to cope with the resource “outside” by developing proper institutions and ...
Kubacki Konrad, Wieprzowski Paweł
doaj +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Clopidogrel Pharmacokinetics in Malaysian Population Groups: The Impact of Inter-Ethnic Variability
Pharmaceuticals, 2018 Malaysia is a multi-ethnic society whereby the impact of pharmacogenetic differences between ethnic groups may contribute significantly to variability in clinical therapy. One of the leading causes of mortality in Malaysia is cardiovascular disease (CVD),
Zaril H. Zakaria +2 more
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Frontiers in Oncology, 2021 Alterations in glycosylation regulate fundamental molecular and cellular processes of cancer, serving as important biomarkers and therapeutic targets.
Jun Wang +11 more
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Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
Beta human papillomavirus 8E6 promotes alternative end joining
eLife, 2023 Double strand breaks (DSBs) are one of the most lethal DNA lesions in cells. The E6 protein of beta-human papillomavirus (HPV8 E6) impairs two critical DSB repair pathways: homologous recombination (HR) and non-homologous end joining (NHEJ).
Changkun Hu +7 more
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