Results 141 to 150 of about 35,169 (184)

Reprogramming autoimmunity: inducing antigen-specific tolerance via apoptotic mimicry in an experimental model of multiple sclerosis. [PDF]

J Neuroinflammation
Eixarch H, Boutitah-Benyaich I, Plaza J, Rodríguez-Vidal S, Salvadó M, Mancera-Arteu M, Almenara-Fuentes L, Dalmases M, Vives-Pi M, Montalban X, Barneda-Zahonero B, Espejo C.   +11 more
europepmc   +1 more source

Liraglutide Attenuates Disease Severity in Experimental Autoimmune Encephalomyelitis by Modulating Splenic T Helper Cell Subsets. [PDF]

Brain Behav
Song S, Li B, Guo R, Zhou Y, Xue Y, Guo L.   +5 more
europepmc   +1 more source

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EAE

Trends in Molecular Medicine, 2011
The high failure rate of immunotherapies in multiple sclerosis (MS) clinical trials demonstrates problems in translating new treatment concepts from animal models to the patient. One main reason for this 'immunotherapy gap' is the usage of immunologically immature, microbiologically clean and genetically homogeneous rodent strains.
't Hart, Bert A., Gran, Bruno, Weissert, Robert   +2 more
openaire   +1 more source

EAE susceptibility in FVB mice

Journal of Neuroscience Research, 2000
The in vivo study of immunologic mechanisms in experimental allergic encephalomyelitis (EAE) requires, in some instances, the use of transgenic mice. As FVB mice represent a strain whose fertilized ova possess a relatively large pronucleus, this is a preferred strain in which to generate mice that are transgenic for a variety of genes.
A M, Baker, M C, Grekova, J R, Richert
openaire   +2 more sources

Ingested (oral) ACTH inhibits EAE

Journal of Neuroimmunology, 2011
Ingested type I IFN and SIRS peptide inhibit EAE. We examined whether another immunoactive protein, ACTH, would have similar anti-inflammatory effects in EAE after oral administration. B6 mice were immunized and gavaged with control saline or ACTH starting on the onset of disease. ACTH decreased clinical score and decreased inflammatory foci.
Staley A, Brod, Zachary M, Hood
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Induction of EAE

2008
Experimental autoimmune encephalomyelitis (EAE) can be induced by two principal approaches. The first is based on direct immunization with autoantigen in combination with different types of adjuvant. The second approach of inducing EAE consists in adoptive transfer of activated T cells that are specific for myelin-associated autoantigens of the central
Eli Ben-Chetrit, Stefan Brocke
openaire   +1 more source

Ingested (oral) tocilizumab inhibits EAE

Cytokine, 2014
Blocking the activity of IL-6 can inhibit autoimmune diseases such as rheumatoid arthritis and Crohn's disease.We examined whether an antibody against IL-6, tocilizumab (TCZ) (Actemra®), used clinically in rheumatoid arthritis (RA) would have similar anti-inflammatory effects in EAE after oral administration.B6 mice were immunized with MOG peptide 35 ...
Staley A, Brod, Victoria L, Bauer
openaire   +2 more sources