Results 1 to 10 of about 40,882 (158)
Evaluation of methods of modeling and formation of experimental allergic encephalomyelitis [PDF]
Research Results in Pharmacology, 2022 Introduction: Experimental autoimmune (allergic) encephalomyelitis (EAE) induced by intradermal injection of homogenate of the brain, spinal cord and peripheral nerve with Freund’s stimulator, refers to a true autoimmune disease of the nervous system.
Oleksandr O. Nefodov +5 more
doaj +3 more sources
Neural Regeneration Research, 2020 Multiple sclerosis is an autoimmune neurodegenerative disease of the central nervous system characterized by pronounced inflammatory infiltrates entering the brain, spinal cord and optic nerve leading to demyelination.
Bridget Martinez, Philip V Peplow
doaj +1 more source
Should mast cells be considered therapeutic targets in multiple sclerosis?
Neural Regeneration Research, 2020 Mast cells are immune cells of the myeloid lineage that are found throughout the body, including the central nervous system. They perform many functions associated with innate and specific immunity, angiogenesis, and vascular homeostasis.
Karen Henriette Pinke +3 more
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Amelioration of experimental autoimmune encephalomyelitis by anatabine. [PDF]
PLoS ONE, 2013 Anatabine, a naturally occurring alkaloid, is becoming a commonly used human food supplement, taken for its claimed anti-inflammatory properties although this has not yet been reported in human clinical trials.
Daniel Paris +7 more
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Contribution of pannexin1 to experimental autoimmune encephalomyelitis. [PDF]
PLoS ONE, 2013 Pannexin1 (Panx1) is a plasma membrane channel permeable to relatively large molecules, such as ATP. In the central nervous system (CNS) Panx1 is found in neurons and glia and in the immune system in macrophages and T-cells. We tested the hypothesis that
Sarah E Lutz +10 more
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Silencing miR-150 Ameliorates Experimental Autoimmune Encephalomyelitis
Frontiers in Neuroscience, 2018 MiR-150 regulates maturation and differentiation of T cells but how it functions in multiple sclerosis (MS) is unclear. In miR-150 knockout (KO) mice, we examined the effect of miR-150 deletion on disease severity of experimental autoimmune ...
Zhaolan Hu +8 more
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Cells, 2023 Our previous work demonstrated that vitamin D (VitD) reduces experimental autoimmune encephalomyelitis (EAE) disease severity in wild-type (WT) but not in T cell-specific glucocorticoid (GC) receptor (GR)-deficient (GRlck) mice.
Maud Bagnoud +7 more
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Peptide immunotherapy in experimental autoimmune encephalomyelitis
Biomedical Journal, 2015 We now have potent drugs available to treat the inflammatory component of multiple sclerosis (MS). However, not all patients respond, the drugs are not curative, and the associated risks to beneficial immune surveillance are considerable.
Stephen M Anderton
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PLoS ONE, 2019 Antibodies, including antibodies to the RNA binding protein heterogeneous nuclear ribonucleoprotein A1, have been shown to contribute to the pathogenesis of multiple sclerosis, thus it is important to assess their biological activity using animal models ...
Sangmin Lee +2 more
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Journal of Neuroinflammation, 2017 Background Hypomethylation of the cathepsin Z locus has been proposed as an epigenetic risk factor for multiple sclerosis (MS). Cathepsin Z is a unique lysosomal cysteine cathepsin expressed primarily by antigen presenting cells.
Euan R. O. Allan +9 more
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