DCIR-mediated inhibitory regulation of TLR7-MyD88 axis prevents autoimmune neuroinflammation [PDF]
iScienceSummary: Encephalitogenic T cells are responsible for developing autoimmune diseases in the central nervous system (CNS), but the pathogenesis of CNS autoimmune diseases remains incompletely understood.
Atsushi Fujioka +11 more
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Peptide immunotherapy in experimental autoimmune encephalomyelitis
Biomedical Journal, 2015 We now have potent drugs available to treat the inflammatory component of multiple sclerosis (MS). However, not all patients respond, the drugs are not curative, and the associated risks to beneficial immune surveillance are considerable.
Stephen M Anderton
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Liraglutide Attenuates Disease Severity in Experimental Autoimmune Encephalomyelitis by Modulating Splenic T Helper Cell Subsets [PDF]
Brain and BehaviorObjective To investigate the therapeutic effects of liraglutide, a glucagon‐like peptide‐1 receptor agonist, on clinical progression and splenic T‐cell subsets in experimental autoimmune encephalomyelitis (EAE), a murine model of multiple sclerosis ...
Shuang Song +5 more
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Amelioration of experimental autoimmune encephalomyelitis by anatabine. [PDF]
PLoS ONE, 2013 Anatabine, a naturally occurring alkaloid, is becoming a commonly used human food supplement, taken for its claimed anti-inflammatory properties although this has not yet been reported in human clinical trials.
Daniel Paris +7 more
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Experimental autoimmune encephalomyelitis
Biomedical Journal, 2015 Jean Kanellopoulos
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RETRACTED: Haghmorad et al. Oral Administration of Myelin Oligodendrocyte Glycoprotein Attenuates Experimental Autoimmune Encephalomyelitis through Induction of Th2/Treg Cells and Suppression of Th1/Th17 Immune Responses. Curr. Issues Mol. Biol. 2022, 44, 5728–5740 [PDF]
Current Issues in Molecular BiologyThe journal retracts the article “Oral Administration of Myelin Oligodendrocyte Glycoprotein Attenuates Experimental Autoimmune Encephalomyelitis through Induction of Th2/Treg Cells and Suppression of Th1/Th17 Immune Responses” [...]
Dariush Haghmorad +9 more
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Evaluation of methods of modeling and formation of experimental allergic encephalomyelitis [PDF]
Research Results in Pharmacology, 2022 Introduction: Experimental autoimmune (allergic) encephalomyelitis (EAE) induced by intradermal injection of homogenate of the brain, spinal cord and peripheral nerve with Freund’s stimulator, refers to a true autoimmune disease of the nervous system.
Oleksandr O. Nefodov +5 more
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Experimental Autoimmune Encephalomyelitis in the Mouse [PDF]
Current Protocols in Immunology, 1996 AbstractThis unit details the materials and methods required for both active induction and adoptive transfer of experimental autoimmune encephalomyelitis (EAE) in the SJL mouse strain using intact proteins or peptides from the two major myelin proteins: proteolipid protein (PLP) and myelin basic protein (MBP).
Stephen D, Miller, William J, Karpus
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Neural Regeneration Research, 2020 Multiple sclerosis is an autoimmune neurodegenerative disease of the central nervous system characterized by pronounced inflammatory infiltrates entering the brain, spinal cord and optic nerve leading to demyelination.
Bridget Martinez, Philip V Peplow
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Should mast cells be considered therapeutic targets in multiple sclerosis?
Neural Regeneration Research, 2020 Mast cells are immune cells of the myeloid lineage that are found throughout the body, including the central nervous system. They perform many functions associated with innate and specific immunity, angiogenesis, and vascular homeostasis.
Karen Henriette Pinke +3 more
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