Results 31 to 40 of about 49,920 (244)

Review: ‘Gimme five’: future challenges in multiple sclerosis. ECTRIMS Lecture 2009 [PDF]

, 2010
This article is based on the ECTRIMS lecture given at the 25th ECTRIMS meeting which was held in Düsseldorf, Germany, from 9 to 12 September 2009. Five challenges have been identified: (1) safeguarding the principles of medical ethics; (2) optimizing the
Hohlfeld, Reinhard, Hohlfeld, R., Reinhard Hohlfeld   +2 more
core   +1 more source

The LPS receptor, CD14, in experimental autoimmune encephalomyelitis and multiple sclerosis [PDF]

, 2006
Innate immune receptors are crucial for defense against microorganisms. Recently, a cross-talk between innate and adaptive immunity has been considered. Here, we provide first evidence for a role of the key innate immune receptor, LPS receptor (CD14) in ...
Letiembre, Maryse, Engelhardt, B., Doering, Axinia, Wenlin Hao, Hao, W. L., Doering, A., Yang Liu, Fassbender, Klaus, Bernreuther, Christian, Walter, Silke, Klaus Fassbender, Axinia Doering, Maryse Letiembre, Markus Glatzel, Christian Bernreuther, Diem, Ricarda, Walter, S., Engelhardt, Britta, Liu, Yang, Liu, Y., Britta Engelhardt, Ricarda Diem, Silke Walter, Glatzel, Markus, Hao, Wenlin   +24 more
core   +1 more source

Targeting of prion-infected lymphoid cells to the central nervous system accelerates prion infection

Journal of Neuroinflammation, 2012
Background Prions, composed of a misfolded protein designated PrPSc, are infectious agents causing fatal neurodegenerative diseases. We have shown previously that, following induction of experimental autoimmune encephalomyelitis, prion-infected mice ...
Friedman-Levi Yael, Hoftberger Romana, Budka Herbert, Mayer-Sonnenfeld Tehila, Abramsky Oded, Ovadia Haim, Gabizon Ruth   +6 more
doaj   +1 more source

Tim-3 Relieves Experimental Autoimmune Encephalomyelitis by Suppressing MHC-II

Frontiers in Immunology, 2022
Tim-3, an immune checkpoint inhibitor, is widely expressed on the immune cells and contributes to immune tolerance. However, the mechanisms by which Tim-3 induces immune tolerance remain to be determined.
Lili Tang, Ge Li, Yang Zheng, Chunmei Hou, Yang Gao, Ying Hao, Zhenfang Gao, Rongliang Mo, Yuxiang Li, Beifen Shen, Renxi Wang, Zhiding Wang, Zhiding Wang, Gencheng Han   +13 more
doaj   +1 more source

Innate immune activation in experimental autoimmune myocarditis [PDF]

, 2007
Dilated cardiomyopathy (DCM) is a leading cause of heart failure and frequently results from postinfectious autoimmunity. Its pathophysiology is modeled by experimental autoimmune myocarditis (EAM), a CD4+ T-cell mediated murine model of ...
Marty, René Roger
core   +1 more source

Growth Differentiation Factor 11 Is a Circulating Regulator of Oligodendrocyte Differentiation and CNS Myelin Formation and Repair. [PDF]

CNS Neurosci Ther
Systemically administered GDF11 enhances CNS myelin formation and repair across both developmental and disease contexts. GDF11 promotes the differentiation of oligodendrocyte progenitor cells into mature oligodendrocytes, increases myelin sheath thickness in neonatal mice, and accelerates remyelination in both the cuprizone‐induced demyelination model ...
Zhang Z, Yan M, Huang W, Chen Y, Lv T, Chen W.   +5 more
europepmc   +2 more sources

Impact of Siponimod on Enteric and Central Nervous System Pathology in Late-Stage Experimental Autoimmune Encephalomyelitis. [PDF]

, 2022
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS). Although immune modulation and suppression are effective during relapsing-remitting MS, secondary progressive MS (SPMS) requires neuroregenerative therapeutic options ...
Bigaud, Marc, Michael Enders, Christopher Kapitza, Marc Bigaud, Kirchner, Philipp, Kuerten, Stefanie, Ekici, Arif, Enders, Michael, Kapitza, Christopher, Philipp Kirchner, Wörl, Jürgen, Stefanie Kuerten, Arif Ekici, Jürgen Wörl, Alicia Weier, Weier, Alicia   +15 more
core   +1 more source

MOGAD Is the Most Common Cause of Isolated Optic Neuritis in Children

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives The study aimed to characterize the clinical features, etiologies, and outcomes of isolated, first‐time pediatric ON in the post‐MOG‐IgG era. Methods This was a single‐center retrospective cohort study at Texas Children's Hospital of patients diagnosed with first‐time ON between 2018–2024, with follow‐up data collected through 2025.
Chaitanya Aduru, Akansha Chandrasekar, Kyla Blasingame, Jonathan Rosen, Jesse M. Levine, Karla Salazar, Madhuri Chilakapati, Rod Foroozan, Victoria Hardwick, Jonathan M. Yarimi, Nikita Shukla, Timothy E. Lotze, Kristen S. Fisher, Alexander J. Sandweiss   +13 more
wiley   +1 more source

Two Years Later: Journals Are Not Yet Enforcing the ARRIVE Guidelines on Reporting Standards for Pre-Clinical Animal Studies [PDF]

, 2014
There is growing concern that poor experimental design and lack of transparent reporting contribute to the frequent failure of pre-clinical animal studies to translate into treatments for human disease.
Sandra Amor (506326), Lidster, K., Baker, David, Amor, Sandra, Sottomayor, A, Baker David, Sottomayor, Ana, Amor, S., David Baker (11642), Sottomayor, A., Lidster, Katie, Ana Sottomayor, Lidster Katie, Baker, D., Baker, D, Lidster, K, Amor, S, Amor Sandra, Katie Lidster, Sandra Amor, Katie Lidster (479714), David Baker, Sottomayor Ana, Ana Sottomayor (506325)   +23 more
core   +1 more source

The Innate Immune Receptor CD14 Mediates Lymphocyte Migration in EAE

Cellular Physiology and Biochemistry, 2015
Background: Multiple sclerosis is the most common autoimmune disease of the central nervous system in young adults and histopathologically characterized by inflammation, demyelination and gliosis.
Ramona Halmer, Laura Davies, Yang Liu, Klaus Fassbender, Silke Walter   +4 more
doaj   +1 more source