Results 11 to 20 of about 40,882 (158)

DCIR-mediated inhibitory regulation of TLR7-MyD88 axis prevents autoimmune neuroinflammation [PDF]

iScience
Summary: Encephalitogenic T cells are responsible for developing autoimmune diseases in the central nervous system (CNS), but the pathogenesis of CNS autoimmune diseases remains incompletely understood.
Atsushi Fujioka, Kenji Shimizu, Saki Nakayama, Dai Ueno, Yuki Chiba, Ichiro Nakashima, Juichi Fujimori, Yuko Shirota, Yoichiro Iwakura, Yasushi Muraki, Akira Nakamura, Tomonori Kaifu   +11 more
doaj   +2 more sources

Liraglutide Attenuates Disease Severity in Experimental Autoimmune Encephalomyelitis by Modulating Splenic T Helper Cell Subsets [PDF]

Brain and Behavior
Objective To investigate the therapeutic effects of liraglutide, a glucagon‐like peptide‐1 receptor agonist, on clinical progression and splenic T‐cell subsets in experimental autoimmune encephalomyelitis (EAE), a murine model of multiple sclerosis ...
Shuang Song, Bin Li, Ruoyi Guo, Yi Zhou, Yumei Xue, Li Guo   +5 more
doaj   +2 more sources

RETRACTED: Haghmorad et al. Oral Administration of Myelin Oligodendrocyte Glycoprotein Attenuates Experimental Autoimmune Encephalomyelitis through Induction of Th2/Treg Cells and Suppression of Th1/Th17 Immune Responses. Curr. Issues Mol. Biol. 2022, 44, 5728–5740 [PDF]

Current Issues in Molecular Biology
The journal retracts the article “Oral Administration of Myelin Oligodendrocyte Glycoprotein Attenuates Experimental Autoimmune Encephalomyelitis through Induction of Th2/Treg Cells and Suppression of Th1/Th17 Immune Responses” [...]
Dariush Haghmorad, Bahman Yousefi, Majid Eslami, Ali Rashidy-Pour, Mahdieh Tarahomi, Maryam Jadid Tavaf, Azita Soltanmohammadi, Simin Zargarani, Aleksandr Kamyshnyi, Valentyn Oksenych   +9 more
doaj   +2 more sources

Korean Red Ginseng mitigates spinal demyelination in a model of acute multiple sclerosis by downregulating p38 mitogen-activated protein kinase and nuclear factor-κB signaling pathways

Journal of Ginseng Research, 2018
Background: The potential therapeutic values of Korean Red Ginseng extract (KRGE) in autoimmune disorders of nervous system have not been fully investigated.
Min Jung Lee, Byung Joon Chang, Seikwan Oh, Seung-Yeol Nah, Ik-Hyun Cho   +4 more
doaj   +1 more source

Amyloids in Site-Specific Autoimmune Reactions and Inflammatory Responses

Frontiers in Immunology, 2020
Amyloid deposition is a histological hallmark of common human disorders including Alzheimer's disease (AD) and type 2 diabetes. Although some reports highlight that amyloid fibrils might activate the innate immunity system via pattern recognition ...
Yan-Mei Huang, Yan-Mei Huang, Xue-Zhi Hong, Xue-Zhi Hong, Jian Shen, Jian Shen, Li-Jun Geng, Li-Jun Geng, Yan-Hong Pan, Yan-Hong Pan, Wei Ling, Wei Ling, Hai-Lu Zhao, Hai-Lu Zhao, Hai-Lu Zhao   +14 more
doaj   +1 more source

Hormones in experimental autoimmune encephalomyelitis (EAE) animal models

Translational Neuroscience, 2021
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS) in which activated immune cells attack the CNS and cause inflammation and demyelination.
Ghareghani Majid, Ghanbari Amir, Eid Ali, Shaito Abdullah, Mohamed Wael, Mondello Stefania, Zibara Kazem   +6 more
doaj   +1 more source

Targeting of prion-infected lymphoid cells to the central nervous system accelerates prion infection

Journal of Neuroinflammation, 2012
Background Prions, composed of a misfolded protein designated PrPSc, are infectious agents causing fatal neurodegenerative diseases. We have shown previously that, following induction of experimental autoimmune encephalomyelitis, prion-infected mice ...
Friedman-Levi Yael, Hoftberger Romana, Budka Herbert, Mayer-Sonnenfeld Tehila, Abramsky Oded, Ovadia Haim, Gabizon Ruth   +6 more
doaj   +1 more source

Tim-3 Relieves Experimental Autoimmune Encephalomyelitis by Suppressing MHC-II

Frontiers in Immunology, 2022
Tim-3, an immune checkpoint inhibitor, is widely expressed on the immune cells and contributes to immune tolerance. However, the mechanisms by which Tim-3 induces immune tolerance remain to be determined.
Lili Tang, Ge Li, Yang Zheng, Chunmei Hou, Yang Gao, Ying Hao, Zhenfang Gao, Rongliang Mo, Yuxiang Li, Beifen Shen, Renxi Wang, Zhiding Wang, Zhiding Wang, Gencheng Han   +13 more
doaj   +1 more source

MOGAD Is the Most Common Cause of Isolated Optic Neuritis in Children

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives The study aimed to characterize the clinical features, etiologies, and outcomes of isolated, first‐time pediatric ON in the post‐MOG‐IgG era. Methods This was a single‐center retrospective cohort study at Texas Children's Hospital of patients diagnosed with first‐time ON between 2018–2024, with follow‐up data collected through 2025.
Chaitanya Aduru, Akansha Chandrasekar, Kyla Blasingame, Jonathan Rosen, Jesse M. Levine, Karla Salazar, Madhuri Chilakapati, Rod Foroozan, Victoria Hardwick, Jonathan M. Yarimi, Nikita Shukla, Timothy E. Lotze, Kristen S. Fisher, Alexander J. Sandweiss   +13 more
wiley   +1 more source

The Innate Immune Receptor CD14 Mediates Lymphocyte Migration in EAE

Cellular Physiology and Biochemistry, 2015
Background: Multiple sclerosis is the most common autoimmune disease of the central nervous system in young adults and histopathologically characterized by inflammation, demyelination and gliosis.
Ramona Halmer, Laura Davies, Yang Liu, Klaus Fassbender, Silke Walter   +4 more
doaj   +1 more source