Results 151 to 160 of about 35,169 (184)
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2008
Adjuvants enhance autoantigens’ immunogenicity and play a major role in the induction of EAE. Complete Freund’s adjuvant (CFA) is the key adjuvant for cell-mediated immunity, including EAE. An additional adjuvant, pertussis toxin, is necessary for active EAE in mice.
Cris S Constantinescu +1 more
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Adjuvants enhance autoantigens’ immunogenicity and play a major role in the induction of EAE. Complete Freund’s adjuvant (CFA) is the key adjuvant for cell-mediated immunity, including EAE. An additional adjuvant, pertussis toxin, is necessary for active EAE in mice.
Cris S Constantinescu +1 more
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International Reviews of Immunology, 1993
This paper describes some of the factors involved in the regulation of EAE and of autoimmunity in general. The immunological homunculus is discussed.
I R, Cohen, F, Mor
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This paper describes some of the factors involved in the regulation of EAE and of autoimmunity in general. The immunological homunculus is discussed.
I R, Cohen, F, Mor
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Ingested (oral) rituximab inhibits EAE
Cytokine, 2016Blocking CD20 can inhibit autoimmune diseases such as multiple sclerosis (MS) and rheumatoid arthritis (RA).We examined whether an antibody against CD20, rituximab (RTX) (Rituxan®), used clinically in oncology, MS and RA would have similar anti-inflammatory effects in EAE after oral administration.B6 mice were immunized with MOG peptide 35-55 and ...
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2008
This chapter reviews the histological structure of the normal central nervous system and the basic pathology of inflammation and demyelination of this tissue. An outline of the pathogenesis of experimental autoimmune encephalomyelitis (EAE) is given and pathology of multiple sclerosis is reviewed.
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This chapter reviews the histological structure of the normal central nervous system and the basic pathology of inflammation and demyelination of this tissue. An outline of the pathogenesis of experimental autoimmune encephalomyelitis (EAE) is given and pathology of multiple sclerosis is reviewed.
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Enzymatic Aqueous Extraction (EAE)
2014Aqueous enzymatic extraction is employed for fractionation of plant raw material and for extraction of molecules of interest in a safe manner. For many years, the improvement of industrial enzymes lead to new potentialities and new products and implies today an entire rethinking of green extraction and its economic prospects.
Muniglia, Lionel +3 more
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2008
This chapter reviews briefly the biology of myelin and describes the major CNS myelin proteins, the potential neuroantigens in EAE. The genetics of the principal myelin proteins are also discussed. Myelin glycolipids with potential role in CNS demyelinating disease and the enzymes involved in their synthesis are also reviewed.
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This chapter reviews briefly the biology of myelin and describes the major CNS myelin proteins, the potential neuroantigens in EAE. The genetics of the principal myelin proteins are also discussed. Myelin glycolipids with potential role in CNS demyelinating disease and the enzymes involved in their synthesis are also reviewed.
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The Journal of Immunology, 2016
Abstract TLR2 expression is enhanced in MS and EAE, but its role in these diseases is controversial. In adoptive transfer EAE, exogenous TLR ligands are not administered yet TLR2-deficient mice have been reported to develop attenuated disease. Despite this evidence for a disease-promoting function of TLR2, others have shown the opposite,
Emily J Anstadt +3 more
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Abstract TLR2 expression is enhanced in MS and EAE, but its role in these diseases is controversial. In adoptive transfer EAE, exogenous TLR ligands are not administered yet TLR2-deficient mice have been reported to develop attenuated disease. Despite this evidence for a disease-promoting function of TLR2, others have shown the opposite,
Emily J Anstadt +3 more
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Increasing CNS Noradrenaline Reduces EAE Severity
Journal of Neuroimmune Pharmacology, 2009The endogenous neurotransmitter noradrenaline (NA) is known to exert potent anti-inflammatory effects in glial cells, as well as provide neuroprotection against excitatory and inflammatory stimuli. These properties raise the possibility that increasing levels of NA in the central nervous system (CNS) could provide benefit in neurological diseases and ...
Maria Vittoria, Simonini +5 more
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2008
Intramolecular and intermolecular epitope spreading, the development of immune cells with new reactivities different from the original immunodominant response, plays an important role in the relapses and progression of EAE and has been implicated in the progression of MS. This chapter describes the process of epitope spreading in EAE, its impact on the
Andrea E. Edling, Vincent K. Tuohy
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Intramolecular and intermolecular epitope spreading, the development of immune cells with new reactivities different from the original immunodominant response, plays an important role in the relapses and progression of EAE and has been implicated in the progression of MS. This chapter describes the process of epitope spreading in EAE, its impact on the
Andrea E. Edling, Vincent K. Tuohy
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2008
The EAE lesion is initiated by CD4+ T cells. Although this statement still holds, recent work has shown that CD8+ T cells and possibly γδ T cells can also contribute to pathology. The recovery phase of the disease poses more of a challenge with the potential for various regulatory T cell populations to halt the pathology.
Kelli Ryan, Stephen M Anderton
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The EAE lesion is initiated by CD4+ T cells. Although this statement still holds, recent work has shown that CD8+ T cells and possibly γδ T cells can also contribute to pathology. The recovery phase of the disease poses more of a challenge with the potential for various regulatory T cell populations to halt the pathology.
Kelli Ryan, Stephen M Anderton
openaire +1 more source