Results 31 to 40 of about 37,192 (202)
m6A‐Mediated Glycolysis by IL‐37 Drives T Cell Metabolic Reprogramming to Regulate Colitis
Advanced Science, EarlyView.This study identifies an IL‐37/SIGIRR‐METTL14 regulatory axis that suppresses global m6A modification in CD4+ T cells. IL‐37 signaling, mediated through SIGIRR, inhibits IRAK4 and JNK phosphorylation, leading to downregulation of the methyltransferase METTL14.
Xiaoyan Wang +26 more
wiley +1 more source
The Journal of Experimental Medicine, 2006 An excess of proteinase receptors in the brain aggravates demyelination in multiple sclerosis (MS), suggest Noorbakhsh and colleagues on page 425. Mice lacking proteinase-activated receptor-2 (PAR2), they show, are protected from the brain damage characteristic of experimental autoimmune encephalomyelitis (EAE), a model of MS.
openaire +1 more source
Autoantigen mRNA‐LNP Vaccination Drives Therapeutic Efficacy in Preclinical Models for Autoimmunity
Advanced Science, EarlyView.Systemic and intramuscular delivery of autoantigen mRNA via lipid nanoparticles reprograms antigen‐presenting cells toward a mature, homeostatic state, driving antigen‐specific T cell exhaustion and providing therapeutic efficacy across autoimmune disease models.
Paulien Baeten +30 more
wiley +1 more source
Advanced Science, EarlyView.Embryonic amoxicillin exposure disrupts multi‐organ development in zebrafish larvae through a lncRNA–metabolic enzyme regulatory axis. PCALRx associates with pyruvate carboxylase, promotes PC protein ubiquitination, and impairs mitochondrial energy metabolism, while vitamin B1 partially restores PC‐centered metabolic function and developmental outcomes.
Yixue Yao +5 more
wiley +1 more source
Advanced Science, EarlyView.A Sr‐free air electrode for high‐temperature solid oxide cells is designed by independently tailoring electronic conduction, ionic transport, and surface catalysis using complementary Sr‐free phases and infiltrated nanocatalysts. It delivers performance comparable to state‐of‐the‐art Sr‐containing electrodes while completely suppressing Cr‐induced ...
Ji‐eun Won +10 more
wiley +1 more source
Modelo de trabajo colaborativo online desde la perspectiva socioemocional
RIED: Revista Iberoamericana de Educación a DistanciaEl hecho de que un grupo de estudiantes online trabaje de forma conjunta en un cometido académico no es sinónimo de que lo hagan colaborativamente. Para que los alumnos se puedan desempeñar de esa forma (y que los profesores la puedan llegar a evocar ...
Adolfo Montalvo García +2 more
doaj +1 more source
Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.OxSpred, an eXtreme‐Gradient‐Boosting‐‐based supervised learning model, accurately annotates oxidative stress in innate immune cells at the single‐cell level, providing interpretable embeddings with significant biological relevance. This innovative tool revolutionizes the understanding of innate immune cell functions during inflammation and enhances ...
Po‐Yuan Chen, Tai‐Ming Ko
wiley +1 more source
Telos: Revista de Estudios Interdisciplinarios en Ciencias Sociales, 2023 La llegada del telégrafo, el tendido del primer cable transatlántico, a fines del siglo XIX, sentaron los fundamentos del primer periodo de globalización financiera.
Eduardo Carlos Dittmar
doaj +1 more source
Advanced Intelligent Systems, EarlyView.This study introduces Cellular Material Network (CM‐Net), a pioneering machine learning architecture integrating physical information, to predict the mechanical properties of cellular materials. Comprehensive validation through simulations and experiments demonstrates its accuracy in predicting nonlinear behaviors, including initial peak compression ...
Sicong Zhou +5 more
wiley +1 more source
Área AbiertaLa innovación digital en las empresas avanza sensiblemente en la Sociedad de la Banda Ancha. En la pandemia, a marchas forzadas, se replantearon las operaciones para adaptarlas a las necesidades del momento en cada departamento y área empresarial ...
Joan-Francesc Fondevila-Gascón +3 more
doaj +1 more source