Results 91 to 100 of about 653,076 (299)
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
The Indexing Paradox -- Be Thankful for Irrational Investors [PDF]
This paper introduces the indexing paradox, which states that it if all investors are rational with rational expectations and have a common risk-averse investment performance measure, then no investor can expect to do better than the market.
David Eagle
core
Quantification of land-use impact on stream water quality [PDF]
, 2002 Accelerated eutrophication of Beaver Lake in northwest Arkansas is a major environmental concern. When developing watershed-management plans to protect lake water quality, it is important that linkages among land-use activities and water quality of ...
Chaubey, Indrajeet +2 more
core +2 more sources
FEBS Open Bio, EarlyView.Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar +4 more
wiley +1 more source
Two\u27s Company but Three\u27s a Crowd: A Study on the Crowd in the Book of Acts [PDF]
, 2015 The book of Acts is an entity of its own. While it is a part of the canonical Bible as one of the sixty-six books, it is unique in that it presents the continuation of God’s plan from Jesus Christ to the growth of the early Christian church.
Eagle, Dylan
core +1 more source
FEBS Open Bio, EarlyView.In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara +3 more
wiley +1 more source
Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz +3 more
wiley +1 more source
Revista Chilena de Historia Natural, 2001 Durante dos años (julio 1987enero 1989) se estudió la biología reproductiva del águila (Geranoaetus melanoleucus) en San Carlos de Apoquindo, en Chile central. El inicio del período reproductivo se evidenció por un aumento del número de vuelos en pareja.
EDUARDO F. PAVEZ
doaj
OPTIMALISASI PARTISIPASI ORANGTUA DALAM PENGELOLAAN PROGRAM DI PAUD EAGLE [PDF]
, 2015 Penelitian ini membahas optimalisasi partisipasi orangtua dalam pengelolaan program di PAUD Eagle kecamatan Lembang Kabupaten Bandung Barat. Melihat permasalahan yang ada maka peneliti merumuskan ke dalam beberapa pertanyaan penelitian diantaranya: 1 ...
Susanti, Lidia
core
ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan +9 more
wiley +1 more source