Results 71 to 80 of about 247,106 (313)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Rae Jean Walking Eagle Interview, July 17, 1992 [PDF]
, 1992 Rae Jean Walking Eagle, member of the Sioux tribe, recounts how her mother taught her to quilt when Walking Eagle was in fifth grade. Walking Eagle also discusses how her mother supported the family by sewing. Walking Eagle describes completing her first
Walking Eagle, Rae Jean
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Frontiers in Veterinary ScienceThere is a trade-off between sow and piglet welfare in farrowing pens, whereby increased behavioural freedom of sows results in unacceptable levels of piglet mortality.
Kate J. Plush +4 more
doaj +1 more source
Ecology and Evolution, 2020 Genetic stock identification is a widely applied tool for the mixed‐stock management of salmonid species throughout the North Pacific Rim. The effectiveness of genetic stock identification is dependent on the level of differentiation among stocks which ...
John H. Powell, Matthew R. Campbell
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Conservation Status of Breeding Eagles in France
Пернатые хищники и их охрана, 2019 Seven species of eagle breed in France: Golden Eagle (Aquila chrysaetos), Lesser Spotted Eagle (Aquila pomarina), Bonelli’s Eagle (Aquila fasciata), Booted Eagle (Hieraaetus pennatus), Short-toed Eagle (Circaetus gallicus), Osprey (Pandion haliaetus) and
Hugo Pontalier +7 more
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Eagle Point Notice of Adopted Amendment (2012-01-17)
, 2012 19 pp. Adopted 2012-01-17. Department of Land Conservation and Development Notice of Adopted AmendmentThe amendment changed the zoning from heavy commercial (C-2) to retail commercial (C-l). We are aware of the warning not to "see attached." Despite that,
Eagle Point (Or.)
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Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source