Results 81 to 90 of about 247,106 (313)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

Philip H. Red Eagle

open access: yes, 2017
Philip H. Red Eagle was born in 1945 in Tacoma, Washington. His mother, Marian Steilacoom, of Salish decent, was born near Port Angeles, Washington. Philip's father, Philip Red Eagle, a member of the Dakota Tribe, was born near the Missouri River on the ...
Red Eagle, Philip H., Woolston, Jordan
core  

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

open access: yesFEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart   +7 more
wiley   +1 more source

Radar data processing, quality analysis and level-1b product generation for AGRISAR and EAGLE campaigns

open access: yes, 2007
For the assessment of specific programmatic needs of the Sentinel program and for the understanding and quantification of bio-geophysical parameters of different vegetated surfaces ESA has initiated and partially funded two airborne campaigns in 2006 ...
Hajnsek, Irena   +5 more
core  

The Legal Eagle Restaurant Menus 2020

open access: yes, 2020
If only all pubs could grow up to be like this revamped veteran beside the Four Courts. The evolution of the Legal Eagle under the talented restaurateur Elaine Murphy put a dream list of Irish food, craft beer and cider, and gutsy flavours into the ...
Eagle, Legal
core  

Animal Symbolism and Sacred Landscape from the Goddess Temple at Niuheliang: The Bear, Eagle, and Owl in Perspective

open access: yesReligions
The Goddess Temple at Niuheliang, located in Chaoyang City, Liaoning Province, is the earliest known temple excavated in China, offering profound insights into Neolithic religious architecture.
Qian Wang
doaj   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

open access: yesFEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui   +10 more
wiley   +1 more source

Transportation system plan : City of Eagle Point, Oregon

open access: yes, 2001
170 pp. Includes maps and figures. Adopted September 25, 2001. Received from ODOT January 2, 2007.This plan provides an overall strategy to develop a safe and efficient transportation system for the City of Eagle Point which meets not only the needs of ...
Rogue Valley Council of Governments   +1 more
core  

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel   +4 more
wiley   +1 more source

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