Results 41 to 50 of about 653,076 (299)

Intranasal delivery of shRNA to knockdown the 5HT-2A receptor enhances memory and alleviates anxiety

Translational Psychiatry
Short-hairpin RNAs (shRNA), targeting knockdown of specific genes, hold enormous promise for precision-based therapeutics to treat numerous neurodegenerative disorders.
Troy T. Rohn, Dean Radin, Tracy Brandmeyer, Peter G. Seidler, Barry J. Linder, Tom Lytle, John L. Mee, Fabio Macciardi   +7 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Numbers and distribution of eagles in the Czech Republic: reason for optimism

Пернатые хищники и их охрана, 2023
At present, four eagle species are regular breeders in the Czech Republic: White Tailed Sea-Eagle (Haliaeetus albicilla), Eastern Imperial Eagle (Aquila heliaca), Lesser Spotted Eagle (Aquila [Clanga] pomarina), and Golden Eagle (Aquila chrysaetos ...
Tomáš Bělka, David Horal
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

The prey of the Harpy Eagle in its last reproductive refuges in the Atlantic Forest

Scientific Reports, 2023
The Harpy Eagle (Harpia harpyja) is threatened with extinction throughout its distribution in the neotropical forests. In the Atlantic Forest, deforestation has reduced the number of suitable habitats, with only a few remnant forest fragments hosting ...
Mylena Kaizer, Brener Fabres, Francisca Helena Aguiar-Silva, Tânia Margarete Sanaiotti, Alexandro Ribeiro Dias, Aureo Banhos   +5 more
doaj   +1 more source

White Eagle Breakfast Speech [PDF]

, 1984
Speech for the White Eagle Breakfast, Chicago, IL, October, 13, 1984.https://ir.lawnet.fordham.edu/vice_presidential_campaign_speeches_1984/1049/thumbnail ...
Ferraro, Geraldine
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Birds of Malagos Watershed: A Comparative Sourvey

JPAIR, 2008
The study titled "Birds of Malagos Watershed, Southeastern Philippines" highlights the avifaunal richness of Mindanao, one of the most biodiverse islands in the Philippines.
Geonsyl L. Alviola, Julie B. Otadoy, Bernadette I. del Rosario, Jason Ibañez   +3 more
doaj   +1 more source

Saturation and elementary equivalence of C*-algebras

, 2015
We study the saturation properties of several classes of $C^*$-algebras. Saturation has been shown by Farah and Hart to unify the proofs of several properties of coronas of $\sigma$-unital $C^*$-algebras; we extend their results by showing that some ...
Eagle, Christopher J., Vignati, Alessandro   +1 more
core   +3 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source