Results 41 to 50 of about 247,106 (313)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

EAGLE Vocabularies RDF data

, 2019
The data under the EAGLE Vocabularies https://www.eagle-network.eu/resources/vocabularies/ . The latest version can always be found in the GitHub repository where these vocabularies are maintained https://github.com/EAGLE-BPN/epidocupconversion/tree ...
Pietro Liuzzo, Herbert Verreth, Anita Rocco, Anita Rocco (8289078), Silvia Evangelisti, Silvia Evangelisti (8289069), Donato Fasolini, Pietro Liuzzo (8315070), Donato Fasolini (8315076), Herbert Verreth (8315073)   +9 more
core   +1 more source

A Salamon trónja, a Targum Sheni Eszter tükrében

Studia Universitatis Babeş-Bolyai. Theologia Reformata Transylvanica
The Throne of Solomon as Reflected in Targum Sheni. The Hebrew and Aramaic targum means ‘translation’, ‘variant’. They are extremely readable, if only because they are not literal translations but also include an explanation of the text, including ...
János MÁRTON
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Intranasal delivery of shRNA to knockdown the 5HT-2A receptor enhances memory and alleviates anxiety

Translational Psychiatry
Short-hairpin RNAs (shRNA), targeting knockdown of specific genes, hold enormous promise for precision-based therapeutics to treat numerous neurodegenerative disorders.
Troy T. Rohn, Dean Radin, Tracy Brandmeyer, Peter G. Seidler, Barry J. Linder, Tom Lytle, John L. Mee, Fabio Macciardi   +7 more
doaj   +1 more source

The Eagle jugular syndrome [PDF]

Veins and Lymphatics, 2019
Not ...
Zamboni, Paolo, Scerrati, Alba, Menegatti, Erica, Galeotti, Roberto, Lapparelli, Marcello, Traina, Luca, Tessari, Mirko, Ciorba, Andrea, De Bonis, Pasquale, Pelucchi, Stefano   +9 more
openaire   +7 more sources

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Numbers and distribution of eagles in the Czech Republic: reason for optimism

Пернатые хищники и их охрана, 2023
At present, four eagle species are regular breeders in the Czech Republic: White Tailed Sea-Eagle (Haliaeetus albicilla), Eastern Imperial Eagle (Aquila heliaca), Lesser Spotted Eagle (Aquila [Clanga] pomarina), and Golden Eagle (Aquila chrysaetos ...
Tomáš Bělka, David Horal
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source