Results 61 to 70 of about 646,835 (301)
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Fisheries and Aquatic Sciences, 2019 The development of sex-specific genetic assays in a species provides both a method for identifying the system of sex determination and a valuable tool to address questions of conservation and management importance.
Ninh V. Vu +3 more
doaj +1 more source
Ecology and Evolution, 2021 Mating systems and patterns of reproductive success in fishes play an important role in ecology and evolution. While information on the reproductive ecology of many anadromous salmonids (Oncorhynchus spp.) is well detailed, there is less information for ...
John S. Hargrove +4 more
doaj +1 more source
Spatial prediction of species’ distributions from occurrence-only records: combining point pattern analysis, ENFA and regression-kriging [PDF]
, 2009 A computational framework to map species’ distributions (realized density) using occurrence-only data and environmental predictors is presented and illustrated using a textbook example and two case studies: distribution of root vole (Microtes oeconomus ...
Dilo, Arta +3 more
core +3 more sources
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Ecology and Evolution, 2020 Genetic stock identification is a widely applied tool for the mixed‐stock management of salmonid species throughout the North Pacific Rim. The effectiveness of genetic stock identification is dependent on the level of differentiation among stocks which ...
John H. Powell, Matthew R. Campbell
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Frontiers in Veterinary ScienceThere is a trade-off between sow and piglet welfare in farrowing pens, whereby increased behavioural freedom of sows results in unacceptable levels of piglet mortality.
Kate J. Plush +4 more
doaj +1 more source
Conservation Status of Breeding Eagles in France
Пернатые хищники и их охрана, 2019 Seven species of eagle breed in France: Golden Eagle (Aquila chrysaetos), Lesser Spotted Eagle (Aquila pomarina), Bonelli’s Eagle (Aquila fasciata), Booted Eagle (Hieraaetus pennatus), Short-toed Eagle (Circaetus gallicus), Osprey (Pandion haliaetus) and
Hugo Pontalier +7 more
doaj +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source