Results 71 to 80 of about 646,835 (301)
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Completing Markets in a One-Good, Pure Exchange Economy Without State-Contingent Securities [PDF]
Pareto-efficient consumption in a pure-exchange, one good economy varies over states of nature with respect to only two factors: real aggregate supply and individual utility shocks.
David Eagle
core
Volume 25, Number 1 - February 1947 [PDF]
, 1947 Volume 25, Number 1 – February 1947. 58 pages including covers and advertisements. Editorial Doherty, R.E. The Beast O\u27Brien, John J. On Coffee Eagle, George L. A Stranger in Strasbourg Shanley, Joseph V. Reflections Doherty, R.E.
core +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Two\u27s Company but Three\u27s a Crowd: A Study on the Crowd in the Book of Acts [PDF]
, 2015 The book of Acts is an entity of its own. While it is a part of the canonical Bible as one of the sixty-six books, it is unique in that it presents the continuation of God’s plan from Jesus Christ to the growth of the early Christian church.
Eagle, Dylan
core +1 more source
Two-Stage Eagle Strategy with Differential Evolution [PDF]
, 2012 Efficiency of an optimization process is largely determined by the search algorithm and its fundamental characteristics. In a given optimization, a single type of algorithm is used in most applications.
Deb, Suash, Yang, Xin-She
core +1 more source
FEBS Open Bio, EarlyView.We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima +4 more
wiley +1 more source
EAGLE—A Scalable Query Processing Engine for Linked Sensor Data [PDF]
, 2019 Recently, many approaches have been proposed to manage sensor data using semantic web technologies for effective heterogeneous data integration. However, our empirical observations revealed that these solutions primarily focused on semantic relationships
G. Breslin, John +4 more
core +1 more source