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The Role of FoxG1 in the Inner Ear [PDF]
Frontiers in Cell and Developmental Biology, 2020 Sensorineural deafness is mainly caused by damage to the tissues of the inner ear, and hearing impairment has become an increasingly serious global health problem.
Yanyan Ding +7 more
doaj +5 more sources
Communications Medicine, 2021 Plain language summary Coronavirus disease 2019 (COVID-19) is an infectious disease caused by the novel coronavirus SARS-CoV-2. A growing number of sensory symptoms have been linked to this illness.
Minjin Jeong +15 more
doaj +2 more sources
Dual contribution to amplification in the mammalian inner ear [PDF]
Phys. Rev. Lett. 105, 118102 (2010), 2010 The inner ear achieves a wide dynamic range of responsiveness by mechanically amplifying weak sounds. The enormous mechanical gain reported for the mammalian cochlea, which exceeds a factor of 4,000, poses a challenge for theory. Here we show how such a large gain can result from an interaction between amplification by low-gain hair bundles and a ...
A. J. Hudspeth +4 more
arxiv +3 more sources
Knockout of dhx38 Causes Inner Ear Developmental Defects in Zebrafish [PDF]
BiomedicinesBackground: Alternative splicing is essential for the physiological and pathological development of the inner ear. Disruptions in this process can result in both syndromic and non-syndromic forms of hearing loss.
Mengmeng Ren +14 more
doaj +2 more sources
Modulation of Wnt Signaling Enhances Inner Ear Organoid Development in 3D Culture. [PDF]
PLoS ONE, 2016 Stem cell-derived inner ear sensory epithelia are a promising source of tissues for treating patients with hearing loss and dizziness. We recently demonstrated how to generate inner ear sensory epithelia, designated as inner ear organoids, from mouse ...
Rachel E DeJonge +5 more
doaj +2 more sources
Defective Tmprss3-Associated Hair Cell Degeneration in Inner Ear Organoids [PDF]
Stem Cell Reports, 2019 Summary: Mutations in the gene encoding the type II transmembrane protease 3 (TMPRSS3) cause human hearing loss, although the underlying mechanisms that result in TMPRSS3-related hearing loss are still unclear.
Pei-Ciao Tang +8 more
doaj +3 more sources
Current and emerging approaches to cochlear immunosuppression with translation to human inner ear stem cell therapy: A systematic review. [PDF]
PLoS OneHearing loss is a significant health burden across all stages of life. One in 5 people suffer hearing loss, with 5% of the world's population experiencing disabling hearing loss.
Creber NJ +5 more
europepmc +3 more sources
Mechanical network equivalence between the katydid and mammalian inner ears. [PDF]
PLoS Computational BiologyMammalian hearing operates on three basic steps: 1) sound capturing, 2) impedance conversion, and 3) frequency analysis. While these canonical steps are vital for acoustic communication and survival in mammals, they are not unique to them.
Emine Celiker +8 more
doaj +2 more sources
Instrument flight to the inner ear [PDF]
Science Robotics, 2017 Image-guided robotic surgery, designed for operating on small structures, is demonstrated for robotic cochlear implantation. Surgical robot systems can work beyond the limits of human perception, dexterity, and scale, making them inherently suitable for ...
S. Weber +16 more
semanticscholar +4 more sources
Scientific Reports, 2021 Hearing loss is a common disability affecting the world’s population today. While several studies have shown that inner ear gene therapy can be successfully applied to mouse models of hereditary hearing loss to improve hearing, most of these studies rely
Jianliang Zhu +6 more
doaj +1 more source