Results 11 to 20 of about 1,188,756 (285)
Journal of Neuroscience, 2020 Age-related hearing loss arises from irreversible damage in the inner ear, where sound is transduced into electrical signals. Prior human studies suggested that sensory-cell loss is rarely the cause; correspondingly, animal work has implicated the stria ...
P. Wu +6 more
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Inner Ear Gene Therapies Take Off: Current Promises and Future Challenges
Journal of Clinical Medicine, 2020 Hearing impairment is the most frequent sensory deficit in humans of all age groups, from children (1/500) to the elderly (more than 50% of the over-75 s). Over 50% of congenital deafness are hereditary in nature.
S. Delmaghani, A. El-Amraoui
semanticscholar +1 more source
Exosomes mediate sensory hair cell protection in the inner ear.
Journal of Clinical Investigation, 2020 Hair cells are the mechanosensory receptors of the inner ear, responsible for hearing and balance. Hair cell death and consequent hearing loss are common results of treatment with ototoxic drugs, including the widely-used aminoglycoside antibiotics ...
Andrew M. Breglio +12 more
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The Mechanosensory Transduction Machinery in Inner Ear Hair Cells.
Annual Review of Biophysics, 2020 Sound-induced mechanical stimuli are detected by elaborate mechanosensory transduction (MT) machinery in highly specialized hair cells of the inner ear.
Wang Zheng, J. R. Holt
semanticscholar +1 more source
Editorial: Neuroimmunology of the Inner Ear [PDF]
Frontiers in Neurology, 2021 © 2021 Perin, Marino, Varela-Nieto and Szczepek. Although the term was first officially used in 1982 (1), neuroimmunology is now a mature field that has gained immense traction in the past decade. Thanks to novel technological advances, the cellular and molecular mechanisms that mediate the crosstalk between the immune and nervous systems are ...
Paola Perin +6 more
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Drug Delivery across Barriers to the Middle and Inner Ear
Advanced Functional Materials, 2020 The prevalence of ear disorders has spurred efforts to develop drug delivery systems to treat these conditions. Here, recent advances in drug delivery systems that access the ear through the tympanic membrane (TM) are reviewed.
Zipei Zhang +3 more
semanticscholar +1 more source
The inner ear and the neurologist [PDF]
Journal of Neurology, Neurosurgery & Psychiatry, 2007 Inner ear disorders are common and patients with vestibular failure often present to a neurology clinic because of their dizziness, gait unsteadiness and oscillopsia. Vestibular disorders can be divided into peripheral and central vestibular disorders.
Michael Gleeson +2 more
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Antioxidant Therapy against Oxidative Damage of the Inner Ear: Protection and Preconditioning
Antioxidants, 2020 Oxidative stress is an important mechanism underlying cellular damage of the inner ear, resulting in hearing loss. In order to prevent hearing loss, several types of antioxidants have been investigated; several experiments have shown their ability to ...
J. Pak +3 more
semanticscholar +1 more source
Mouse Embryonic Fibroblasts-Derived Extracellular Matrix Facilitates Expansion of Inner Ear-Derived Cells [PDF]
Cell Journal, 2023 Objective: Previous reports showed that mouse embryonic fibroblasts (MEFs) could support pluripotent stem cell selfrenewaland maintain their pluripotency.
Junming Zhang +4 more
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Development of the inner ear [PDF]
Current Opinion in Genetics & Development, 2015 The vertebrate inner ear is a sensory organ of exquisite design and sensitivity. It responds to sound, gravity and movement, serving both auditory (hearing) and vestibular (balance) functions. Almost all cell types of the inner ear, including sensory hair cells, sensory neurons, secretory cells and supporting cells, derive from the otic placode, one of
openaire +3 more sources