Results 11 to 20 of about 438,577 (299)

Defective Tmprss3-Associated Hair Cell Degeneration in Inner Ear Organoids [PDF]

Stem Cell Reports, 2019
Summary: Mutations in the gene encoding the type II transmembrane protease 3 (TMPRSS3) cause human hearing loss, although the underlying mechanisms that result in TMPRSS3-related hearing loss are still unclear.
Pei-Ciao Tang, Alpha L. Alex, Jing Nie, Jiyoon Lee, Adam A. Roth, Kevin T. Booth, Karl R. Koehler, Eri Hashino, Rick F. Nelson   +8 more
doaj   +3 more sources

Refining surgical techniques for efficient posterior semicircular canal gene delivery in the adult mammalian inner ear with minimal hearing loss

Scientific Reports, 2021
Hearing loss is a common disability affecting the world’s population today. While several studies have shown that inner ear gene therapy can be successfully applied to mouse models of hereditary hearing loss to improve hearing, most of these studies rely
Jianliang Zhu, Jin Woong Choi, Yasuko Ishibashi, Kevin Isgrig, Mhamed Grati, Jean Bennett, Wade Chien   +6 more
doaj   +1 more source

Fzd3 Expression Within Inner Ear Afferent Neurons Is Necessary for Central Pathfinding

Frontiers in Neuroscience, 2022
During development the afferent neurons of the inner ear make precise wiring decisions in the hindbrain reflective of their topographic distribution in the periphery.
Zachary A. Stoner, Elizabeth M. Ketchum, Sydney Sheltz-Kempf, Paige V. Blinkiewicz, Karen L. Elliott, Jeremy S. Duncan, Jeremy S. Duncan   +6 more
doaj   +1 more source

Nanocarriers for Inner Ear Disease Therapy

Frontiers in Cellular Neuroscience, 2021
Hearing loss is a common disease due to sensory loss caused by the diseases in the inner ear. The development of delivery systems for inner ear disease therapy is important to achieve high efficiency and reduce side effects.
Xiaoxiang Xu, Xiaoxiang Xu, Jianwei Zheng, Yanze He, Kun Lin, Shuang Li, Ya Zhang, Peng Song, Yuye Zhou, Yuye Zhou, Xiong Chen   +10 more
doaj   +1 more source

The inner ear and the neurologist [PDF]

Journal of Neurology, Neurosurgery & Psychiatry, 2007
Inner ear disorders are common and patients with vestibular failure often present to a neurology clinic because of their dizziness, gait unsteadiness and oscillopsia. Vestibular disorders can be divided into peripheral and central vestibular disorders.
Charlotte, Agrup, Michael, Gleeson, Peter, Rudge   +2 more
openaire   +2 more sources

Inner ear malformation

Listy klinicke logopedie, 2020
Inner ear malformation comprises a broad group of disorders, the main symptom of which is hearing loss. The disorder occurs during the embryonic development of the auditory system. Only about 20 % of malformations can be diagnosed radiologically. Hearing
Dagmar Hošnová, Milan Urík
doaj   +1 more source

The Role of FoxG1 in the Inner Ear

Frontiers in Cell and Developmental Biology, 2020
Sensorineural deafness is mainly caused by damage to the tissues of the inner ear, and hearing impairment has become an increasingly serious global health problem.
Yanyan Ding, Wei Meng, Weijia Kong, Zuhong He, Renjie Chai, Renjie Chai, Renjie Chai, Renjie Chai   +7 more
doaj   +1 more source

Role of the hindbrain in dorsoventral but not anteroposterior axial specification of the inner ear [PDF]

, 2005
An early and crucial event in vertebrate inner ear development is the acquisition of axial identities that in turn dictate the positions of all subsequent inner ear components.
Bok, Jinwoong, Bronner-Fraser, Marianne, Wu, Doris K.   +2 more
core   +1 more source

Mouse Embryonic Fibroblasts-Derived Extracellular Matrix Facilitates Expansion of Inner Ear-Derived Cells [PDF]

Cell Journal, 2023
Objective: Previous reports showed that mouse embryonic fibroblasts (MEFs) could support pluripotent stem cell selfrenewaland maintain their pluripotency.
Junming Zhang, Li Liu, Yuexia Li, Jinglei Wu, Xiangxin Lou   +4 more
doaj   +1 more source

Proteomics and the Inner Ear [PDF]

Disease Markers, 2001
The inner ear, one of the most complex organs, contains within its bony shell three sensory systems, the evolutionary oldest gravity receptor system, the three semicircular canals for the detection of angular acceleration, and the auditory system ‐ unrivaled in sensitivity and frequency discrimination.
openaire   +2 more sources