Results 221 to 230 of about 1,367,224 (352)

Restoration, Not Bypass: Otoferlin Gene Therapy and a New Era in Hearing Loss Treatment

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract The FDA approval of Otarmeni, an AAV‐based gene therapy for biallelic OTOF‐associated sensorineural hearing loss, represents a conceptual shift in otology: from bypassing defective auditory physiology to restoring it. Unlike cochlear implantation, which circumvents damaged sensory structures, OTOF gene replacement targets a synaptic deficit in
Jazlyn A. Selvasingh, Justin R. Shinn
wiley   +1 more source

Deep Learning-Based Inner Ear Subregion Segmentation in 3D T2-Weighted MRI Using Label-Preserving Data Augmentation. [PDF]

NMR Biomed
Kim W, Kang Y, Lee S, Lee HJ, Nam Y.
europepmc   +1 more source

Dress for success: climate pressures predict fur insulation and body size in natural and reintroduced populations of a threatened marsupial

Oikos, EarlyView.
Phenotypic variation in functional traits underpins responses to environmental gradients, influencing thermoregulation, energy balance, and long‐term persistence under climate extremes. Climate change is altering these gradients globally, yet in species that have already disappeared from much of their range, adaptive phenotypes may have also been lost,
Jack Bilby, Kenny J. Travouillon, Emma Sherratt, William K. Cornwell, Katherine Moseby   +4 more
wiley   +1 more source

A Rare Case of Co-occurring Ménière's Disease and Red Ear Syndrome. [PDF]

Cureus
Sperling EL, Elsalanty ME.
europepmc   +1 more source

Delivery of Adeno-Associated Virus Vectors in Adult Mammalian Inner-Ear Cell Subtypes Without Auditory Dysfunction

Human Gene Therapy, 2017
Yong Tao, Mingqian Huang, Y. Shu, A. Ruprecht, Hongyang Wang, Yong Tang, L. Vandenberghe, Qiuju Wang, G. Gao, W. Kong, Zheng-Yi Chen   +10 more
semanticscholar   +1 more source

Prenatal Spectrum of COL2A1‐Related Spondyloepiphyseal Dysplasia Congenita: A Review and Two Case Reports

Prenatal Diagnosis, EarlyView.
ABSTRACT Objective To review the published literature on prenatal findings of COL2A1‐related SEDC, summarizing reported imaging and molecular variants, and to describe two additional prenatal cases evaluated at a tertiary referral center. Method A narrative review with a systematic search strategy was conducted to analyze prenatal imaging findings ...
López‐Rodríguez Larissa, León‐Madero Luis Felipe, Jiménez‐Chaidez Salvador, Gallardo‐Gaona Juan Manuel, Rodríguez‐Sibaja María Jose, Castañeda‐de‐la‐Fuente Angelica, Del Castillo‐Reyes Katia Alejandra, Yañez‐Felix Ana Lucia, Morales‐Dominguez Valeria, Borboa‐Olivares Héctor Jesús, Sevilla‐Montoya Rosalba   +10 more
wiley   +1 more source

The biophysical properties of IK,L in mammalian vestibular type I hair cells and how they are affected by the nerve calyx [PDF]

, 2015
MANCA, MARCO, MASETTO, SERGIO, MAGISTRETTI, JACOPO, RUSSO, GIANCARLO, TAVAZZANI, ELISA, SPAIARDI, PAOLO, PRIGIONI, IVO   +6 more
core  

Steroids for the Prevention of Sensorineural Hearing Loss Secondary to Acute Otitis Media: A Systematic Review. [PDF]

Int Arch Otorhinolaryngol
Sampaio AFBS, Monsanto RDC, Jorge JJ, Borges GC.   +3 more
europepmc   +1 more source

Sudden Deafness Secondary to a Middle Ear/Inner Ear Interaction: The Implications of finding an “Adhesive Tent” during Tympanotomy

Ear, nose, & throat journal, 2009
M. Paparella
semanticscholar   +1 more source

Applications and prospects of artificial intelligence and digital medicine in pediatric nasal skull base tumors

Pediatric Investigation, EarlyView.
Pediatric nasal skull base tumors present diagnostic and therapeutic challenges due to their deep location, nonspecific symptoms, and the narrow nasal cavity in children. Although artificial intelligence (AI) and digital medicine have advanced early diagnosis, multidisciplinary treatment, and prognosis, their application in these rare tumors remains ...
Xiuping Wu, Jing Wei, Chen Liu, Pengpeng Wang, Wentong Ge, Yang Han   +5 more
wiley   +1 more source