Results 31 to 40 of about 434,910 (305)

Gene Delivery into the Inner Ear and Its Clinical Implications for Hearing and Balance

Molecules, 2018
The inner ear contains many types of cell, including sensory hair cells and neurons. If these cells are damaged, they do not regenerate. Inner ear disorders have various etiologies.
Sho Kanzaki
doaj   +1 more source

Nanoparticles in Inner Ear Diseases

National Board of Examinations Journal of Medical Sciences, 2023
Nanoparticles are novel discoveries which hold a promising role for delivering medications into the inner ear in the future. Nanoparticles are formed by the preparation of different biomaterials.
Soumick Ranjan Sahoo
doaj   +1 more source

Histone demethylase KDM4B regulates otic vesicle invagination via epigenetic control of Dlx3 expression [PDF]

, 2015
In vertebrates, the inner ear arises from the otic placode, a thickened swathe of ectoderm that invaginates to form the otic vesicle. We report that histone demethylase KDM4B is dynamically expressed during early stages of chick inner ear formation.
Acloque, Ailín L. Buzzi, Alvarez, Baker, Barald, Barembaum, Beyer, Bokoch, Borges, Bradnam, Brown, Brown, Campanero, Chen, Cheng, Christophorou, Cobos, Couture, Deitcher, Driver, Dutton, Emmett, Fodor, Gerchman, Govek, Groves, Hans, Hofmann, Kalari, Kawazu, Lee, Li, Liu, Luo, Majewski, Marianne E. Bronner, Martin, Moro-Balbás, Neves, Pablo H. Strobl-Mazzulla, Park, Represa, Rosa A. Uribe, Sai, Sai, Siegfried, Sims, Stevens, Streit, Strobl-Mazzulla, Tan, Theveneau, Van Kerschaver, Visconti   +53 more
core   +3 more sources

Round window membrane and delivery of biologically active agents into the cochlea [PDF]

, 2010
Establishing efficient methods for local administration of drugs to the inner ear has great clinical relevance for the management of inner ear disorders. However, the administration route remains a critical issue.
Saber, Amanj K.
core   +1 more source

NADPH Oxidase 3 Deficiency Protects From Noise-Induced Sensorineural Hearing Loss

Frontiers in Cell and Developmental Biology, 2022
The reactive oxygen species (ROS)-generating NADPH oxidase NOX3 isoform is highly and specifically expressed in the inner ear. NOX3 is needed for normal vestibular development but NOX-derived ROS have also been implicated in the pathophysiology of ...
Francis Rousset, German Nacher-Soler, Vivianne Beatrix Christina Kokje, Vivianne Beatrix Christina Kokje, Stéphanie Sgroi, Marta Coelho, Karl-Heinz Krause, Pascal Senn, Pascal Senn   +8 more
doaj   +1 more source

Genetic Causes of Inner Ear Anomalies: a Review from the Turkish Study Group for Inner Ear Anomalies

Balkan Medical Journal, 2019
Inner ear anomalies diagnosed using a radiological study are detected in almost 30% of cases with congenital or prelingual-onset sensorineural hearing loss.
Emre Ocak, Duygu Duman, Mustafa Tekin
doaj   +1 more source

Multimodal Atlas of the Murine Inner Ear: From Embryo to Adult

Frontiers in Neurology, 2021
The inner ear is a complex organ housed within the petrous bone of the skull. Its intimate relationship with the brain enables the transmission of auditory and vestibular signals via cranial nerves.
Jean-Paul Bryant, Vikram Chandrashekhar, Vikram Chandrashekhar, Anthony J. Cappadona, Pashayar P. Lookian, Pashayar P. Lookian, Vibhu Chandrashekhar, Danielle R. Donahue, Jeeva B. Munasinghe, H. Jeffrey Kim, H. Jeffrey Kim, Alexander O. Vortmeyer, John D. Heiss, Zhengping Zhuang, Jared S. Rosenblum, Jared S. Rosenblum   +15 more
doaj   +1 more source

Nanoparticle drug delivery systems for inner ear therapy: An overview [PDF]

, 2017
open7noembargoed_20180701Valente, Filippo; Astolfi, Laura; Simoni, Edi; Danti, Serena; Franceschini, Valeria; Chicca, Milvia; Martini, AlessandroValente, Filippo; Astolfi, Laura; Simoni, Edi; Danti, Serena; Franceschini, Valeria; Chicca, Milvia; Martini,
Astolfi, Laura, Chicca, Milvia, DANTI, SERENA, Franceschini, Valeria, Martini, Alessandro, Simoni, Edi, Valente, Filippo   +6 more
core   +2 more sources

Precision medicine: a new era for inner ear diseases

Frontiers in Pharmacology
The inner ear is the organ responsible for hearing and balance. Inner ear dysfunction can be the result of infection, trauma, ototoxic drugs, genetic mutation or predisposition. Often, like for Ménière disease, the cause is unknown.
Elisa Tavazzani, Elisa Tavazzani, Paolo Spaiardi, Paolo Spaiardi, Donatella Contini, Giulio Sancini, Giulio Sancini, Giancarlo Russo, Sergio Masetto   +8 more
doaj   +1 more source

Generation of Vestibular Tissue-Like Organoids From Human Pluripotent Stem Cells Using the Rotary Cell Culture System

Frontiers in Cell and Developmental Biology, 2019
Hair cells are specialized mechanosensitive cells responsible for mediating balance and hearing within the inner ear. In mammals, hair cells are limited in number and do not regenerate.
Cristiana Mattei, Cristiana Mattei, Rebecca Lim, Hannah Drury, Babak Nasr, Babak Nasr, Babak Nasr, Zihui Li, Melissa A. Tadros, Giovanna M. D'Abaco, Kathryn S. Stok, Bryony A. Nayagam, Mirella Dottori, Mirella Dottori, Mirella Dottori   +14 more
doaj   +1 more source