Results 31 to 40 of about 1,188,756 (285)
AAV-ie enables safe and efficient gene transfer to inner ear cells
Nature Communications, 2019 Hearing loss is the most common sensory disorder. While gene therapy has emerged as a promising treatment of inherited diseases like hearing loss, it is dependent on the identification of gene delivery vectors.
Fangzhi Tan +16 more
semanticscholar +1 more source
Biocompatibility of Liposome Nanocarriers in the Rat Inner Ear After Intratympanic Administration
Nanoscale Research Letters, 2017 Liposome nanocarriers (LPNs) are potentially the future of inner ear therapy due to their high drug loading capacity and efficient uptake in the inner ear after a minimally invasive intratympanic administration.
Jing Zou +4 more
doaj +1 more source
Potential application value of pigment epithelium-derived factor in sensorineural hearing loss
Frontiers in Neuroscience, 2023 The inner ear is a complex and precise auditory perception system responsible for receiving and converting sound signals into neural signals, enabling us to perceive and understand sound.
Zihui Sun +12 more
doaj +1 more source
AAV2.7m8 is a powerful viral vector for inner ear gene therapy
Nature Communications, 2019 Adeno-associated virus (AAV) has been successfully used to deliver gene therapy to improve auditory function in mouse models of hereditary hearing loss.
Kevin T. Isgrig +5 more
semanticscholar +1 more source
Journal of Nanobiotechnology, 2010 Background Treatment of inner ear diseases remains a problem because of limited passage through the blood-inner ear barriers and lack of control with the delivery of treatment agents by intravenous or oral administration. As a minimally-invasive approach,
Kinnunen Paavo KJ +6 more
doaj +1 more source
Improved TMC1 gene therapy restores hearing and balance in mice with genetic inner ear disorders
Nature Communications, 2019 Fifty percent of inner ear disorders are caused by genetic mutations. To develop treatments for genetic inner ear disorders, we designed gene replacement therapies using synthetic adeno-associated viral vectors to deliver the coding sequence for ...
Carl Nist-Lund +11 more
semanticscholar +1 more source
Autophagy in the Vertebrate Inner Ear [PDF]
Frontiers in Cell and Developmental Biology, 2017 Autophagy is a conserved catabolic process that results in the lysosomal degradation of cell components. During development, autophagy is associated with tissue and organ remodeling, and under physiological conditions it is tightly regulated as it plays a housekeeping role in removing misfolded proteins and damaged organelles.
Marta Magariños +9 more
openaire +6 more sources
Gene Delivery into the Inner Ear and Its Clinical Implications for Hearing and Balance
Molecules, 2018 The inner ear contains many types of cell, including sensory hair cells and neurons. If these cells are damaged, they do not regenerate. Inner ear disorders have various etiologies.
Sho Kanzaki
doaj +1 more source
Inner ear delivery: Challenges and opportunities
Laryngoscope Investigative Otolaryngology, 2019 The treatment of inner ear disorders remains challenging due to anatomic barriers intrinsic to the bony labyrinth. The purpose of this review is to highlight recent advances and strategies for overcoming these barriers and to discuss promising future ...
Betsy Szeto +5 more
semanticscholar +1 more source
Multimodal Atlas of the Murine Inner Ear: From Embryo to Adult
Frontiers in Neurology, 2021 The inner ear is a complex organ housed within the petrous bone of the skull. Its intimate relationship with the brain enables the transmission of auditory and vestibular signals via cranial nerves.
Jean-Paul Bryant +15 more
doaj +1 more source