Results 81 to 90 of about 438,577 (299)

Microwave‐Assisted Aqueous Synthesis of Gelatin‐Norbornene for Hydrogel Crosslinking and Bioprinting

Advanced Materials Technologies, EarlyView.
A microwave‐assisted reaction is utilized to synthesize gelatin‐norbornene (GelNB), achieving a high degree of norbornene functionalization while reducing the macromer's upper critical solution temperature. The resulting GelNB macromer has high solubility at room temperature, facilitating light‐based 3‐dimensional (3D) printing of thiol‐norbornene ...
Jonathan B. Bryan, Chien‐Chi Lin
wiley   +1 more source

Molecular characterization and prospective isolation of human fetal cochlear hair cell progenitors

Nature Communications, 2018
Hearing requires mechanosensitive hair cells in the organ of Corti, which derive from progenitors of the cochlear duct. Here the authors examine human inner ear development by studying key developmental markers and describe organoid cultures from human ...
Marta Roccio, Michael Perny, Megan Ealy, Hans Ruedi Widmer, Stefan Heller, Pascal Senn   +5 more
doaj   +1 more source

LDL receptor-related protein 1 (LRP1), a novel target for opening the blood-labyrinth barrier (BLB)

Signal Transduction and Targeted Therapy, 2022
Inner ear disorders are a cluster of diseases that cause hearing loss in more than 1.5 billion people worldwide. However, the presence of the blood-labyrinth barrier (BLB) on the surface of the inner ear capillaries greatly hinders the effectiveness of ...
Xi Shi, Zihao Wang, Wei Ren, Long Chen, Cong Xu, Menghua Li, Shiyong Fan, Yuru Xu, Mengbing Chen, Fanjun Zheng, Wenyuan Zhang, Xinbo Zhou, Yue Zhang, Shiwei Qiu, Liyuan Wu, Peng Zhou, Xinze Lv, Tianyu Cui, Yuehua Qiao, Hui Zhao, Weiwei Guo, Wei Chen, Song Li, Wu Zhong, Jian Lin, Shiming Yang   +25 more
doaj   +1 more source

A Degradable Device for Sustainable Capillary Blood Sampling

Advanced Materials Technologies, EarlyView.
The device features a compostable 3D‐printed storage compartment for liquid blood collection and a degradable, poly(ɛ‐caprolactone)‐coated magnesium microneedle patch hidden within a suction cup. Manual compression deploys the MNs, creating small skin punctures, and the subsequent release of compression generates the negative pressure required for ...
Nicole Zoratto, Hanna Krupke, Valeria Mantella, Daniel Gao, David Klein Cerrejon, Jean‐Christophe Leroux   +5 more
wiley   +1 more source

Knockout of dhx38 Causes Inner Ear Developmental Defects in Zebrafish

Biomedicines
Background: Alternative splicing is essential for the physiological and pathological development of the inner ear. Disruptions in this process can result in both syndromic and non-syndromic forms of hearing loss.
Mengmeng Ren, Xiang Chen, Liyan Dai, Jiayi Tu, Hualei Hu, Xiaohan Sun, Jiong Luo, Pei Li, Yiyang Fu, Yuejie Zhu, Weiqiang Sun, Zhaohui Tang, Mugen Liu, Xiang Ren, Qunwei Lu   +14 more
doaj   +1 more source

A unique radioprotective effect of resolvin E1 reduces irradiation-induced damage to the inner ear by inhibiting the inflammatory response

Radiation Oncology, 2020
Background In addition to the direct effects of irradiation, the induced inflammatory response may play an important role in the damage to the inner ear caused by radiotherapy for the treatment of head and neck cancers.
Jie Zhang, Anting Xu, Tingting Niu, Chengcheng Liu, Yongju Zhang, Tao Li, Jihua Wang, Yongjing Wang, Dianshui Sun   +8 more
doaj   +1 more source

Inner-ear abnormalities and their functional consequences in Belgian Waterslager canaries (Serinus canarius) [PDF]

, 1994
Recent reports of elevated auditory thresholds in canaries of the Belgian Waterslager strain have shown that this strain has an inherited auditory deficit in which absolute auditory thresholds at high frequencies (i.e. above 2.0 kHz) are as much as 40 dB
Brown, Cleveland, Corwin, Cotanche, Cotanche, Cotanche, Cousillas, Dooling, Dooling, Fischer, Geoffrey A. Manley, Girod, Girod, Gleich, Gleich, Gleich, Gleich, Gleich, Gummer, Guttinger, Hashino, Hashino, Köppl, Manley, Manley, Manley, Marler, Nottebohm, Okanoya, Okanoya, Okanoya, Okanoya, Okanoya, Otto Gleich, Patuzzi, Pickles, Robert J. Dooling, Saunders, Steel, Steel, Stresemann, Tilney, Waser   +42 more
core   +1 more source

Waveguide Photoactuators: Materials, Fabrication, and Applications

Advanced Robotics Research, EarlyView.
Waveguide photoactuators convert guided light into mechanical motion. Their tethered‐flexible design enables minimally invasive surgery and confined‐space robotics. This review aims to guide materials selection, device design, and system integration, accelerating the transition of waveguide photoactuators from laboratory prototypes to versatile ...
Minjie Xi, Hemin Pan, Yang Zong, Yongfeng Mei, Jizhai Cui   +4 more
wiley   +1 more source

The Blood-Labyrinth Barrier: Non-Invasive Delivery Strategies for Inner Ear Drug Delivery

Pharmaceutics
The inner ear is a relatively isolated organ, protected by the blood-labyrinth barrier (BLB). This barrier creates a unique lymphatic fluid environment within the inner ear, maintaining a stable physiological state essential for the mechano-electrical ...
Zhangyi Yi, Xiaoying Wang, Ge Yin, Yu Sun   +3 more
doaj   +1 more source

Perilymph pharmacokinetics of marker applied through a cochlear implant in guinea pigs [PDF]

, 2017
Patients undergoing cochlear implantation could benefit from a simultaneous application of drugs into the ear, helping preserve residual low-frequency hearing and afferent nerve fiber populations.
Salt, Alec, Hartsock, Jared, Gill, Ruth, Smyth, Daniel, Kirk, Jonathon, Verhoeven, Kristien   +5 more
core   +3 more sources