Results 141 to 150 of about 563,854 (280)

Photometric and Spectroscopic Studies of Two Early-type Eclipsing Binaries

The Astrophysical Journal
Using high-precision photometric data from the Transiting Exoplanet Survey Satellite, medium-resolution spectroscopic data from the Large Sky Area Multi-Object Fiber Spectroscopy Telescope, and long-term eclipse timings, we provide orbital parameters for
Pengfei Ye, Kai Li, Fei Liu, Xiang Gao, Jing-Yi Wang   +4 more
doaj   +1 more source

The CubeSpec space mission

Astronomy & Astrophysics
Context. Massive stars play a central role in astrophysics, yet their internal structure remains poorly constrained due to uncertainties regarding their core masses, internal rotation, and chemical mixing.
Neuville P., Sana H., Tkachenko A., Royer P., Windey J., Vermant A., Raskin G., Pember J., Bowman D. M., Vandenbussche B.   +9 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

IRAS 17449+2320: A Possible Binary System with the B[e] Phenomenon and a Strong Magnetic Field

Galaxies
We report the recent results of a long-term spectroscopic and photometric monitoring of IRAS 17449+2320, a member of the least studied group of objects with the B[e] phenomenon called FS CMa-type objects.
Sergey Zharikov, Anatoly Miroshnichenko, Inna Reva, Raushan Kokumbaeva, Chingis Omarov, Steve Danford, Alicia Aarnio, Nadine Manset, Ashish Raj, S. Drew Chojnowski, Joseph Daglen   +10 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

The Ejecta Nebula Around the Wolf–Rayet Star WR 71

The Astronomical Journal
We present deep H α and [O iii ] images of the ejecta-rich nebulosity associated with the suspected runaway and binary Wolf–Rayet (WR) star WR 71 (HD 143414). In H α emission, the nebula appears as a crescent shaped, broken ring of clumpy emission some ${
Robert A. Fesen, Manuel C. Peitsch, Martin R. Pugh, Bray Falls, Marcel Drechsler   +4 more
doaj   +1 more source