Results 171 to 180 of about 13,229,627 (267)

Symptom‐Driven Prediction of Chronic Multimorbidity with a Macro–Micro Heterogeneous Graph Neural Network

Advanced Science, EarlyView.
Clinical symptoms offer a window into multimorbidity. A macro‐micro heterogeneous graph neural network integrates clinical records with biomedical knowledge to improve patient‐level symptom‐disease association learning and visit‐level multimorbidity completion.
Yiheng Ye, Miaoru Han, Siqiao Tang, Zongxiang Zhang, Haichen Shen, Bingzhen Sun, Yan Zhang, Xiaodong Chu, Lijuan Deng, Chaoyang Zheng, Qingchun Huang, Kun Bao, Ronghua Zhang, Yong Wang, Fengwei Zhang, Xiaoli Chu   +15 more
wiley   +1 more source

Is early childhood education associated with better midlife cognition, especially for children facing socioeconomic marginalization? [PDF]

PLoS One
Wells W, Hebert J, Eng CW, Duarte CD, Vable AM.   +4 more
europepmc   +1 more source

Arhgef1 Deletion Disrupts Early Cortical Neurogenesis via PAK1 Overactivation and Causes Motor Dysfunction in Adulthood

Advanced Science, EarlyView.
ARHGEF1 plays a pivotal role in both embryonic cortical neurogenesis and adult motor function. During early development, it governs genesis of deep‐layer cortical neurons by negatively regulating RAC1/CDC42‐PAK1‐Cofilin signaling. In adulthood, ARHGEF1 is important for the maintenance of neuronal morphology and activity in the motor cortex, ensuring ...
Liuren Li, Xuanyue Ma, Zhenyu Ding, Bang Sun, Linglin Liu, Hei Matthew Yip, Wei Wang, Tianying Wu, Yuan Guo, Yinghui Peng, Shiqing Zhang, Jacque Pak Kan Ip, Li Zhang, Keshen Li, Lei Shi   +14 more
wiley   +1 more source

Measurement, Process, and Cultural Validity in Mindful Parenting and Preschool Peer Social Competence: Implications for Early Childhood Education [Response to Letter]. [PDF]

Psychol Res Behav Manag
Li H, Li W, Deng J, Deng H, Wen X, Ping Y.   +5 more
europepmc   +1 more source

BRCA1 Mutation‐Recognizing Tetrahedral Framework Nucleic Acid Nanoplatform Enables Coordinated PARP/WEE1 Inhibition and STING‐Associated Antitumor Immunity in Ovarian Cancer

Advanced Science, EarlyView.
BRCA1 mutation‐responsive FBOA‐tFNA selectively recognizes mutant transcripts and coordinates reduction‐responsive intracellular delivery of olaparib and adavosertib, amplifying DNA damage and weakening G2/M checkpoint protection. These effects are accompanied by STING‐associated immune activation and stronger antitumor immunity, while sequential anti ...
Chenyi Wang, Mengying Yao, Jinhui Xie, Dingjie Wang, Yashi Shi, Xiaodan Mao, Chunhua Lu, Pengming Sun   +7 more
wiley   +1 more source

Exploring psychological preparedness for volcanic hazards in early childhood education: A sequential explanatory mixed-methods approach in Ternate Island. [PDF]

Jamba
Ummah DM, Soeparno K, Marfai MA, Pertiwi PP.   +3 more
europepmc   +1 more source

Disrupted Top‐Down Modulation as a Mechanism of Impaired Multisensory Processing in Autistic Children

Advanced Science, EarlyView.
In this work, we show that multisensory integration in autistic children is characterized by attenuated ERP responses and α‐band desynchronization, together with reduced theta‐band communication between parieto‐occipital and frontal regions. The intermediate neural profile observed in unaffected siblings raises the possibility that altered cortical ...
Theo Vanneau, John J. Foxe, Shlomit Beker, Sophie Molholm   +3 more
wiley   +1 more source

Teachers' Perceptions of the PIL-SMART Model: A Semlj Analysis of its Influence on Science and Environmental Literacy in Early Childhood Education. [PDF]

F1000Res
Priyanti N, Apriyansyah C, Andrian T.
europepmc   +1 more source

Extreme Weather Events and Consumer Food Responses

Applied Economic Perspectives and Policy, EarlyView.
ABSTRACT This study investigates consumer food responses to Hurricanes Helene and Milton, which affected a swath of the Southeastern U.S. in 2024. Using representative consumer survey data from six affected states, we analyze 10 distinct food responses classified into ex ante and ex post responses, and examine their associations with food insufficiency
Ahmad Zia Wahdat, Joseph Balagtas
wiley   +1 more source

The Association Between Self-Reported Acquisition of Perinatal Knowledge and Perinatal Depressive Symptoms: Evidence from the Korean Early Childhood Education & Care Panel Study. [PDF]

Epidemiologia (Basel)
Cho HJ, Jung H, Cho GJ, Lee J, Lee JR, Park HS, Kim HS.   +6 more
europepmc   +1 more source