Results 81 to 90 of about 694,269 (310)
Nanoscale Spatial Organization of ARC High‐ and Low‐Order Assemblies at Excitatory Synapses
Advanced Science, EarlyView.ARC (Activity‐Regulated Cytoskeleton‐Associated protein) mediates synaptic plasticity by forming nanoscale assemblies in neurons. Using super‐resolution microscopy and time‐resolved anisotropy with targeted tagging, the study reveals low‐order ARC assemblies at synapses colocalizing with AMPARs, semi‐circular structures at endocytic zones, and 60–80 nm
Martina Damenti +13 more
wiley +1 more source
What Works? A Study of Effective Early Childhood Mental Health Consultation Programs [PDF]
, 2009 Examines factors that lead to desirable outcomes in mental health consultation programs: solid program infrastructure, highly qualified consultants, and quality support services.
Bruno Anthony +6 more
core
Advanced Science, EarlyView.Osteosarcoma stemness is driven by the ITGB2‐COPS3‐SOX2 signaling axis. This study reveals that nuclear COPS3 stabilizes SOX2, which in turn undergoes liquid‐liquid phase separation to promote stemness. Based on this mechanism, a novel COPS3 inhibitor, Z‐5891, was developed, effectively suppressing tumor growth and stemness in vivo, offering a ...
Lei Guo +7 more
wiley +1 more source
Social Validity Assessment in Social Competence Interventions for Preschool Children: A Review [PDF]
, 2012 Social competence intervention studies published from 1970 to 2008 for preschoolers were reviewed for reports of social validity assessment. Analysis of 90 studies indicated that nearly 27% (n=24) of studies reported at least one measure of social ...
Hurley, Jennifer J
core +2 more sources
Hepatocyte BDNF Acts as a Novel Immune Checkpoint to Restrain TLR4‐Mediated Acute Hepatitis
Advanced Science, EarlyView.This study identifies hepatocyte‐derived BDNF as an endogenous TLR4 antagonist that alleviates acute hepatitis. BDNF is downregulated in hepatocytes via REST‐mediated transcriptional repression during ALI/ALF. Mechanistically, BDNF binds to TLR4 on macrophages to suppress inflammation.
Weiwei Zhu +15 more
wiley +1 more source
Early Childhood Special Education Teachers' Job Burnout and Psychological Stress. [PDF]
Early Educ Dev, 2022 Jeon HJ +3 more
europepmc +1 more source
Early Childhood Special Education Services In Turkey
, 2018 Early childhood special education services are provided for children with developmental disabilities or risk factor, who are between 0-8 years old, and their families. In this study, laws, and services provided in our country regarding early childhood special education services are defined; the content of the provided early childhood services programs ...
Özlem Altindağ Kumaş +1 more
openaire +2 more sources
How aligned are we? Assessment procedures and practices between early childhood and early intervention [PDF]
, 2011 Early intervention and early childhood share a unique space in our early years education in Aotearoa/New Zealand. The assessment practices of the two are distinctively different and specific to each discipline.
Caulcutt, Toia, Paki, Vanessa Anne
core +1 more source
Advanced Science, EarlyView.This review surveys nanoparticle‐based strategies to enhance adoptive cell therapy, particularly CAR‐T cell approaches, in solid tumor treatment. It describes how nanoparticles can improve tumor immunogenicity and T‐cell infiltration while reducing toxicity, and how they enable in vivo CAR‐T cell generation.
Erica Frostegård +19 more
wiley +1 more source
Audiology ResearchParenting stress significantly affects caregivers of deaf and hard-of-hearing (DHH) children, influenced by unique challenges and stressors. Background/Objectives: This study aims to develop the Chinese Family Stress Scale (CFSS) and to identify the ...
Yuan Chen, Xiaoli Shen, Chengao Lyu
doaj +1 more source