Results 31 to 40 of about 8,732,098 (315)

Pan-cancer characterization of C–C motif chemokine ligand 5 (CCL5) identifies its role as biomarker and therapeutic target

Discover Oncology
Objectives C–C Motif Chemokine Ligand 5 (CCL5) is known for its role in immune regulation and has been implicated in cancer progression. However, its expression and prognostic significance in pan-cancer require comprehensive evaluation.
Wenming Zhao, Jirui Sun, Bingjuan Zhou, Haizhi Qiao, Jinku Zhang   +4 more
doaj   +1 more source

Unraveling the gut microbiota’s role in obesity: key metabolites, microbial species, and therapeutic insights

Journal of Bacteriology
Obesity, characterized by excessive fat accumulation, stems from an imbalance between energy intake and expenditure, with the gut microbiota playing a crucial role.
Majid Iqbal, Qian Yu, Jingqun Tang, Juanjuan Xiang   +3 more
doaj   +1 more source

Early Diagnosis and Staging [PDF]

Prostate Cancer and Prostatic Diseases, 1999
This report reviews developments in the early diagnosis and staging of prostate cancer and updated on the incidence of postate cancer to discuss the pros and cons of population based screening. Refinements and reliability of various diagnosic procedures are described such as PSA testing, transrectal ultrasound, ratio beteen PSA-level and ultrasound ...
H, Lilja, D R H, Lilja
openaire   +2 more sources

Early childhood flexibility practices and patterns: report 2014 [PDF]

, 2014
The Early childhood flexibility practices and patterns report highlights recommendations and future directions for early childhood education and care (ECEC) services in providing flexible arrangements for families and local communities.
Early Childhood Australia
core  

Early Infant Diagnosis of HIV in Three Regions in Tanzania; Successes and Challenges. [PDF]

, 2013
By the end of 2009 an estimated 2.5 million children worldwide were living with HIV-1, mostly as a consequence of vertical transmission, and more than 90% of these children live in sub-Saharan Africa.
Bygbjerg, Ib Christian, Lemnge, Martha M., Mmbando, Bruno P, Chiduo, Mercy G., Theilgaard, Zarah P., Gerstoft, Jan, Jan Gerstoft, Bruno P Mmbando, Katzenstein, Terese, Lemnge, Martha, Mercy G Chiduo, Ib C Bygbjerg, Terese L Katzenstein, Chiduo, Mercy G, Zahra P Theilgaard, Mmbando, Bruno M., Martha Lemnge, Theilgaard, Zahra P, Katzenstein, Terese L, Bygbjerg, Ib C   +19 more
core   +2 more sources

Ovarian Sex Cord Stromal Tumors in Children and Adolescents—The European Standard Clinical Practice Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT As part of the European Cooperative Study Group for Paediatric Rare Tumours initiative, we developed standard clinical practice guidelines for ovarian sex cord stromal tumors, based on comprehensive national and international cohort analyses, literature review, and a final expert consensus conference.
Dominik T. Schneider, Kris‐Ann Schultz, Nora Schnitzler, Michael Abele, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Ines B. Brecht, Maja Cesen, Andrea Ferrari, Michaela Kuhlen, Malgorzata A. Krawczyk, Ricardo Lopez‐Almaraz, Yves Reguerre, Calogero Virgone, Daniel Orbach   +15 more
wiley   +1 more source

Molecular characterization of HPV integrations in high-risk HPV-positive women and development of a prognostic signature based on integration-associated genes for cervical cancer

Infectious Agents and Cancer
Background HPV integration into the human genome is a key molecular event in the progression of cervical cancer carcinogenesis. Methods This study utilized samples from high-risk HPV-positive women to investigate HPV integration.
Qiongying Lyu, Jiahui Zhao, Yurou Chen, Jiaqiang Xiong, Hairong Wang, Juan Zhang, Lihan Wang, Xiaoyan He, Wei Zhang   +8 more
doaj   +1 more source

Infant Embryonal CNS Tumors: Molecular Insights and Treatment Considerations for Contemporary Pediatric Neuro‐Oncology

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Embryonal tumors comprise the majority of malignant central nervous system (CNS) neoplasms diagnosed in children under 3 years of age. Compared with their counterparts in older children, these tumors exhibit distinct molecular biology and a more aggressive clinical phenotype, while their management is complicated by the heightened ...
Sudarshawn Damodharan, Mariah Wright‐Nadkarni, Mohamed S. Abdelbaki, Girish Dhall   +3 more
wiley   +1 more source

Integrated transcriptomic and immunoinformatics analysis identifies tpx2, bub1b, and ube2c as diagnostic biomarkers and therapeutic targets in endometrial carcinoma

Discover Oncology
Objective This study aimed to identify novel diagnostic and prognostic biomarkers in endometrial carcinoma (EC) using integrative bioinformatics and immunohistochemical validation, with a focus on potential therapeutic targets and immune correlations ...
Shuyang Zhou, Jirui Sun, Jinmei Li, Xing Zhou, Xiaoyu Shi, Minghan Yang, Yanjing Wang, Jinku Zhang   +7 more
doaj   +1 more source

Prognostic role of the platelet to lymphocyte ratio (PLR) in the clinical outcomes of patients with advanced lung cancer receiving immunotherapy: A systematic review and meta-analysis

Frontiers in Oncology, 2022
BackgroundIt remains controversial whether the platelet to lymphocyte ratio (PLR) serves as a potential indicator for the efficacy of immunotherapy in advanced lung cancer.
Ke Zhou, Ke Zhou, Jie Cao, Jie Cao, Huahang Lin, Huahang Lin, Linchuan Liang, Linchuan Liang, Zhongzhong Shen, Lei Wang, Zhiyu Peng, Zhiyu Peng, Jiandong Mei, Jiandong Mei   +13 more
doaj   +1 more source