Results 41 to 50 of about 3,819,422 (303)

Early Diagnosis of Hemoglobinopathies [PDF]

Pediatric Research, 1978
Summary: Antibodies specific for human hemoglobins F, A, S, and C were isolated by affinity chromatography from antisera produced in rabbits and goats. These reagents were shown to possess adequate sensitivity for identifying and quantifying hemoglobins A, S, and C in cord blood by radial immunodiffusion (RID).
V E, Headings, S I, Anyaibe, S P, Bhattacharya, E L, Hopkins   +3 more
openaire   +2 more sources

Clinical Insights Into Hypercalcemia of Malignancy in Childhood

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Hypercalcemia of malignancy (HCM) is a rare but life‐threatening metabolic emergency in children that occurs in less than 1% of pediatric cancer cases, with a reported incidence ranging from 0.4% to 1.0% across different studies. While it is observed in 10%–20% of adult malignancies, pediatric HCM remains relatively uncommon.
Hüseyin Anıl Korkmaz
wiley   +1 more source

Pan-cancer characterization of C–C motif chemokine ligand 5 (CCL5) identifies its role as biomarker and therapeutic target

Discover Oncology
Objectives C–C Motif Chemokine Ligand 5 (CCL5) is known for its role in immune regulation and has been implicated in cancer progression. However, its expression and prognostic significance in pan-cancer require comprehensive evaluation.
Wenming Zhao, Jirui Sun, Bingjuan Zhou, Haizhi Qiao, Jinku Zhang   +4 more
doaj   +1 more source

Early-onset primary antibody deficiency resembling common variable immunodeficiency challenges the diagnosis of Wiedeman-Steiner and Roifman syndromes [PDF]

, 2017
Syndromic primary immunodeficiencies are rare genetic disorders that affect both the immune system and other organ systems. More often, the immune defect is not the major clinical problem and is sometimes only recognized after a diagnosis has been made ...
Bogaert, Delfien, Coppieters, Frauke, De Baere, Elfride, De Baets, Frans, De Bruyne, Marieke, De Schryver, Sarah, De Wilde, Hans, Dullaers, Melissa, Haerynck, Filomeen, Kuehn, Hye Sun, Lambrecht, Bart, Leroy, Bart, Niemela, Julie E, Rosenzweig, Sergio D   +13 more
core   +2 more sources

Survival Outcomes and Complications Among Canadian Children With Retinoblastoma: A Population‐Based Report From CYP‐C

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Retinoblastoma (RB) is the most common pediatric ocular cancer, yet population‐based data on survival and risk factors remain limited. This study aimed to describe survival in a large national RB cohort and identify predictors of death and complications.
Samuel Sassine, Ofélie Trudeau‐Ferrin, Caroline Laverdière, Patrick Hamel, Rosanne Superstein, Bénédicte Koukoui, Carole Provost, Paul C. Nathan, Vijay Ramaswamy, Furqan Shaikh, Brenda Gallie, Ashwin Mallipatna, Stephanie Kletke, Helen Dimaras, Hallie Coltin   +14 more
wiley   +1 more source

Transient epileptic amnesia: an emerging late-onset epileptic syndrome. [PDF]

, 2009
Transient epileptic amnesia (TEA) is a distinct neurologic condition occurring in late-middle/old age and presenting with amnesic attacks of epileptic nature and interictal memory disturbances.
BILO, LEONILDA, de Leva M.F., Meo R., Ruosi P., STRIANO, SALVATORE   +4 more
core   +1 more source

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

Efficacy and safety of lenvatinib plus pembrolizumab in patients with advanced and recurrent endometrial cancer: a systematic review and meta-analysis

Frontiers in Immunology
BackgroundVarious trials have demonstrated the clinical benefits of lenvatinib plus pembrolizumab in patients with advanced or recurrent endometrial cancer, regardless of mismatch repair (MMR) status or histologic subtype.
Guangwei Yan, Guangwei Yan, Yanmin Du, Yanmin Du, Huanhuan Zhang, Huanhuan Zhang, Jinxiang Yan, Jinxiang Yan, Yixuan Liu, Yixuan Liu, Zhenying Ban, Zhenying Ban, Yong-Zhen Guo, Yong-Zhen Guo, Xianxu Zeng, Xianxu Zeng   +15 more
doaj   +1 more source

Decreased IL-6 and NK Cells in Early-Stage Lung Adenocarcinoma Presenting as Ground-Glass Opacity

Frontiers in Oncology, 2021
BackgroundLung ground-glass opacities (GGOs) are an early manifestation of lung adenocarcinoma. It is of great value to study the changes in the immune microenvironment of GGO to elucidate the occurrence and evolution of early lung adenocarcinoma ...
Pengfei Zhang, Pengfei Zhang, Boxue He, Boxue He, Qidong Cai, Qidong Cai, Guangxu Tu, Guangxu Tu, Xiong Peng, Xiong Peng, Zhenyu Zhao, Zhenyu Zhao, Weilin Peng, Weilin Peng, Fenglei Yu, Fenglei Yu, Min Wang, Yongguang Tao, Yongguang Tao, Yongguang Tao, Yongguang Tao, Xiang Wang, Xiang Wang   +22 more
doaj   +1 more source

Pathological features of the placenta in hypothyroidism during pregnancy: a population-based retrospective cohort study in Chinese population

Frontiers in Endocrinology
BackgroundPregnant women, due to changes in their metabolic and immune states, are a high - risk group for thyroid diseases. The most common one among them is hypothyroidism. However, there are few reports on its impact on placental morphology.
Zhuo Bao, Zhuo Bao, Yingbin Li, Yingbin Li, Tong Xue, Tong Xue, Yixuan Liu, Yixuan Liu, Jinxiang Yan, Jinxiang Yan, Xiaoqian Wang, Xiaoqian Wang, Yunling Li, Yunling Li, Xianxu Zeng, Xianxu Zeng, Xianxu Zeng, Chengquan Zhao, Yongzhen Guo, Yongzhen Guo, Dongmei Lei, Dongmei Lei   +21 more
doaj   +1 more source