Results 61 to 70 of about 2,379,974 (319)

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source

Efficacy and safety of PARP inhibitors in advanced or recurrent endometrial cancer: a systematic review and meta-analysis

Frontiers in Immunology
ObjectiveSeveral clinical trials have explored the efficacy and safety of Poly (ADP-ribose) polymerase (PARP) inhibitors in endometrial cancer (EC). However, evidence supporting PARP inhibitors alone or in combination with other medications in advanced ...
Huanhuan Zhang, Huanhuan Zhang, Guangwei Yan, Guangwei Yan, Jinxiang Yan, Jinxiang Yan, Xianxu Zeng, Xianxu Zeng   +7 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

2DSM vs FFDM: A computeraided diagnosis based comparative study for the early detection of breast cancer

, 2021
Purpose Accurate and early detection of breast cancer using effective imaging modalities is an active area of research in medical image analysis. Computeraided diagnosis (CAD) of breast cancer using digital mammograms may help in early diagnosis and can ...
Kartini Rahmat, Chan, Wai Yee, Ng, Kwan Hoong, U. Raghavendra, Raghavendra, U., Rahmat, Kartini, Anjan Gudigar, U. Rajendra Acharya, Ciaccio, Edward J., Wai Yee Chan, Edward J. Ciaccio, Kwan Hoong Ng, Acharya, U. Rajendra, Gudigar, Anjan   +13 more
core   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

The clinical utility of next generation sequencing in endometrial cancer: focusing on molecular subtyping and lynch syndrome

Frontiers in Genetics
ObjectiveTo investigate the clinical utility of Next Generation Sequencing (NGS) in molecular typing of endometrial carcinoma and its combined screening for Lynch Syndrome (LS).Methods90 patients diagnosed with endometrial carcinoma (EC) and receiving ...
Yongzhen Guo, Yongzhen Guo, Guangwei Yan, Guangwei Yan, Pei Zhang, Pei Zhang, Yixuan Liu, Yixuan Liu, Chengquan Zhao, Xianxu Zeng, Xianxu Zeng   +10 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Alternative Splicing in Tumorigenesis and Cancer Therapy

Biomolecules
Alternative splicing (AS) is a pivotal post-transcriptional mechanism that expands the functional diversity of the proteome by enabling a single gene to generate multiple mRNA and protein isoforms.
Huiping Chen, Jingqun Tang, Juanjuan Xiang   +2 more
doaj   +1 more source

From early diagnosis to optimal diagnosis:a conference report on what excellent innovation should look like

Early diagnostic technologies such as in vitro diagnostic medical devices (IVDs) have been promoted by many, including the UK government (2010–2024) as part of its Industrial Strategy.1 In 2024, the new UK government stated that a priority was to ‘make ...
Sullivan, Francis, McCartney, Margaret, Donnelly, Peter Duncan, Wallis , Scott   +3 more
core   +1 more source

The early diagnosis of Alzheimer’s disease

, 2018
Early and accurate diagnosis of Alzheimer’s disease, which is the most common cause of dementia, is of great importance, as it allows pharmacological treatment of patients with dementia due to this disease. Unfortunately, it is often a long-term process,
Anna Barczak
core   +1 more source