Results 71 to 80 of about 8,732,098 (315)

From early diagnosis to optimal diagnosis:a conference report on what excellent innovation should look like

Early diagnostic technologies such as in vitro diagnostic medical devices (IVDs) have been promoted by many, including the UK government (2010–2024) as part of its Industrial Strategy.1 In 2024, the new UK government stated that a priority was to ‘make ...
Sullivan, Francis, McCartney, Margaret, Donnelly, Peter Duncan, Wallis , Scott   +3 more
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Early Diagnosis of Alzheimer's disease by NIRF Spectroscopy and Nuclear Medicine [PDF]

, 2011
There is an urgent need for the early detection of diseases such as Alzheimer’s (AD) and Cancers in order to enable their successful treatment. Cancer is the second major cause of death after Heart Disease, and AD is the third major cause of death
I. C. Baianu
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Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Using the Carrot as the Stick: U.S. Foreign Aid and the Effectiveness of Sanctions Threats

, 2023
These are the replication materials for "Using the Carrot as the Stick," including the STATA data sets, do file, and the Online Appendix. - "Using the Carrot as the Stick - Early and Jadoon.dta" is the main data set - "Threat Imposition Robustness ...
Early, Bryan
core   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Ephs in cancer progression: complexity and context-dependent nature in signaling, angiogenesis and immunity

Cell Communication and Signaling
Eph receptors constitute the largest family of receptor tyrosine kinases, comprising 14 distinct members classified into two subgroups: EphAs and EphBs..
Xiaoting Guo, Yanyi Yang, Jingqun Tang, Juanjuan Xiang   +3 more
doaj   +1 more source

Experience of NHS diagnostic investigation following a multi-cancer early detection (MCED) screening test: qualitative interviews with NHS-Galleri trial participants who had a cancer signal detectedResearch in context

EClinicalMedicine
Summary: Background: Understanding experiences of diagnostic investigation for any new screening modality is important to inform the development of pathways for future implementation. We explored experience of diagnostic work-up within the NHS in people
Laura A.V. Marlow, Ninian Schmeising-Barnes, Jo Waller   +2 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Defining recurrent urinary tract infections and quantifying bladder cancer risk in primary care in England: a nationwide case–control study

The Lancet Primary Care
Summary: Background: Around 30–40% of people with bladder cancer in England present with symptoms or diagnosis of urinary tract infection (UTI) in the year before a diagnosis of bladder cancer.
Sikhuphukile G Mahati, MSc, ProfPhD Jianhua Wu, MSc, ProfMD Fiona M Walter, MSc, Yin Zhou, PhD   +3 more
doaj   +1 more source

Sacroiliitis – early diagnosis is key

, 2018
Gleb Slobodin,1,2 Haya Hussein,1 Itzhak Rosner,1,2 Iris Eshed3,4 1Rheumatology Unit, Bnai Zion Medical Center, Haifa, Israel; 2Ruth and Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel; 3Department of Diagnostic Imaging, Sheba Medical Center,
Rosner I, Hussein H, Eshed I, Slobodin G
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