Results 51 to 60 of about 2,379,974 (319)

Emapalumab for Immune Effector Cell‐Associated Hemophagocytic Lymphohistiocytosis‐Like Syndrome Following CD19‐Directed CAR‐T in Two Patients With B‐ALL: Clinical and Biomarker Correlates

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Immune effector cell‐associated hemophagocytic lymphohistiocytosis‐like syndrome (IEC‐HS) is a life‐threatening hyperinflammatory toxicity distinct from cytokine release syndrome (CRS) and neurotoxicity following chimeric antigen receptor T‐cell (CAR‐T) therapy. In a single‐institution retrospective cohort of pediatric and young adult patients
Thomas J. Galletta, Jeremy D. Rubinstein, Christopher E. Dandoy, Ruby Khoury, Angela Faulhaber, Christine L. Phillips, Christa Krupski   +6 more
wiley   +1 more source

Pathological features of the placenta in hypothyroidism during pregnancy: a population-based retrospective cohort study in Chinese population

Frontiers in Endocrinology
BackgroundPregnant women, due to changes in their metabolic and immune states, are a high - risk group for thyroid diseases. The most common one among them is hypothyroidism. However, there are few reports on its impact on placental morphology.
Zhuo Bao, Zhuo Bao, Yingbin Li, Yingbin Li, Tong Xue, Tong Xue, Yixuan Liu, Yixuan Liu, Jinxiang Yan, Jinxiang Yan, Xiaoqian Wang, Xiaoqian Wang, Yunling Li, Yunling Li, Xianxu Zeng, Xianxu Zeng, Xianxu Zeng, Chengquan Zhao, Yongzhen Guo, Yongzhen Guo, Dongmei Lei, Dongmei Lei   +21 more
doaj   +1 more source

N6-Methyladenosine RNA Methylation Regulator-Related Alternative Splicing (AS) Gene Signature Predicts Non–Small Cell Lung Cancer Prognosis

Frontiers in Molecular Biosciences, 2021
Aberrant N6-methyladenosine (m6A) RNA methylation regulatory genes and related gene alternative splicing (AS) could be used to predict the prognosis of non–small cell lung carcinoma.
Zhenyu Zhao, Zhenyu Zhao, Qidong Cai, Qidong Cai, Pengfei Zhang, Pengfei Zhang, Boxue He, Boxue He, Xiong Peng, Xiong Peng, Guangxu Tu, Guangxu Tu, Weilin Peng, Weilin Peng, Li Wang, Li Wang, Fenglei Yu, Fenglei Yu, Xiang Wang, Xiang Wang   +19 more
doaj   +1 more source

The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli, Seth Rotz, Masatoshi Takagi, Richa Sharma   +3 more
wiley   +1 more source

TAGLN2-Regulated Trophoblast Migration, Invasion and Fusion are Impaired in Preeclampsia

Frontiers in Cell and Developmental Biology, 2022
Preeclampsia (PE) is a serious disease during pregnancy that affects approximately eight million mothers and infants worldwide each year and is closely related to abnormal trophoblast function.
Hao Wang, Hao Wang, Xiaowei Zhang, Xiaowei Zhang, Chunfeng Liu, Chunfeng Liu, Shengfu Chen, Xinyang Liu, Xinyang Liu, Shangrong Fan, Shangrong Fan   +10 more
doaj   +1 more source

Early Diagnosis of Alzheimer’s Disease Based on Convolutional Neural Networks

, 2022
Alzheimer’s disease (AD) is a neurodegenerative disorder, causing the most common dementia in the elderly peoples. The AD patients are rapidly increasing in each year and AD is sixth leading cause of death in USA.
Abugabah, Ahed, Sanzogni, Louis, Mehmood, Atif, AlZubi, Ahmed Ali   +3 more
core   +1 more source

Increased Risk of Sarcomas in Children With Congenital Anomalies: Findings From the Genetic Overlap Between Anomalies and Cancer in Kids (GOBACK) Registry Linkage Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Pediatric sarcomas are a heterogeneous group of tumors that contribute disproportionately to cancer mortality in children. Although congenital anomalies are among the strongest known risk factors for childhood cancer, the risk of specific sarcoma subtypes among affected individuals has not yet been thoroughly evaluated. Procedure We
Russ Wolters, Ji Yun Tark, Tiffany M. Chambers, Tania A. Desrosiers, Michael E. Scheurer, Charles Shumate, Wendy N. Nembhard, Mahsa M. Yazdy, Eirini Nestoridi, Amanda E. Janitz, Jean Paul Tanner, Russell S. Kirby, Jason L. Salemi, Yao Yu, Chad D. Huff, Sharon E. Plon, Philip J. Lupo, Jeremy M. Schraw   +17 more
wiley   +1 more source

Intention to have blood-based multi-cancer early detection (MCED) screening among men and women aged 50–77 years from Black and Asian backgrounds: a cross-sectional survey in Great Britain

BMJ Public Health
Introduction Uptake of cancer screening is lower among people from minority ethnic groups. We aimed to quantify intention and potential barriers and facilitators to uptake of blood-based multi-cancer early detection (MCED) screening among men and women ...
Jo Waller, Laura A V Marlow, Ninian Schmeising-Barnes   +2 more
doaj   +1 more source

Early Diagnosis of Hemoglobinopathies [PDF]

Pediatric Research, 1978
Summary: Antibodies specific for human hemoglobins F, A, S, and C were isolated by affinity chromatography from antisera produced in rabbits and goats. These reagents were shown to possess adequate sensitivity for identifying and quantifying hemoglobins A, S, and C in cord blood by radial immunodiffusion (RID).
V E, Headings, S I, Anyaibe, S P, Bhattacharya, E L, Hopkins   +3 more
openaire   +2 more sources

Early diagnosis of Duchenne muscular dystrophy - a Treat-NMD international workshop

The diagnosis of Duchenne muscular dystrophy (DMD) is significant at any stage, however an early diagnosis in a presymptomatic or very early phase of DMD, offers unique opportunities and challenges for families and health care providers. Currently, there
Jones, Kj, Parsons, Ja, Servais, L, Lorentzos, M   +3 more
core   +1 more source