Results 101 to 110 of about 104,595 (283)

Update on the pathophysiology and management of acute trauma hemorrhage and trauma-induced coagulopathy based upon viscoelastic testing [PDF]

Clinical and Experimental Emergency Medicine
Uncontrolled hemorrhage and trauma-induced coagulopathy (TIC) are the two predominant causes of preventable death after trauma. Early control of bleeding sources and rapid detection, characterization and management of TIC have been associated with ...
Marc Maegele
doaj   +1 more source

Efficacy of early goal-directed therapy using FloTrac/EV1000 to improve postoperative outcomes in patients undergoing off-pump coronary artery bypass surgery: a randomized controlled trial. [PDF]

J Cardiothorac Surg, 2022
Tribuddharat S, Sathitkarnmanee T, Ngamsaengsirisup K, Sornpirom S.   +3 more
europepmc   +1 more source

Goal-directed therapy: hit early and personalize! [PDF]

Journal of Clinical Monitoring and Computing, 2017
Saugel, Bernd, Michard, Frederic, Scheeren, Thomas W L   +2 more
openaire   +2 more sources

Goal-Directed Resuscitation for Patients with Early Septic Shock [PDF]

, 2014
BACKGROUND Early goal-directed therapy (EGDT) has been endorsed in the guidelines of the Surviving Sepsis Campaign as a key strategy to decrease mortality among patients presenting to the emergency department with septic shock. However, its effectiveness
Higgins, Alisa M., ARISE Investigators, Bailey, Michael, Delaney, Anthony, ANZICS Clinical Trials Grp, Williams, Patricia, Cooper, D. James, Cameron, Peter A., Pettilä, Ville, Peake, Sandra L., Bellomo, Rinaldo, Webb, Steven A. R., Holdgate, Anna, Howe, Belinda D.   +13 more
core   +1 more source

Modular Control of PEG‐Poly(2‐Oxazoline) Co‐Assembly Enables Tunable Aggregate Properties for Intraocular Pressure Management

Advanced Healthcare Materials, EarlyView.
A thermo‐responsive poly(2‐oxazoline)‐based injectable formulation is developed to modulate intraocular pressure (IOP) in both normal and hypotonic eyes. By adjusting the PEG content, the aggregation behavior is finely tuned, enabling IOP elevation without long‐term deposition.
Yuji Tanaka, Shohei Morikawa, Shigehito Osawa   +2 more
wiley   +1 more source

Current management of massive hemorrhage in trauma

Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 2012
Hemorrhage remains a major cause of potentially preventable deaths. Trauma and massive transfusion are associated with coagulopathy secondary to tissue injury, hypoperfusion, dilution, and consumption of clotting factors and platelets. Concepts of damage
Johansson Pär I, Stensballe Jakob, Ostrowski Sisse R   +2 more
doaj   +1 more source

A Long‐Lived Human Neurovascular PENTA Culture Model Captures Incomplete Vascular Repair and Glia‐Associated Signaling After Traumatic Brain Injury

Advanced Healthcare Materials, EarlyView.
A long‐lived, five‐cell‐type human neurovascular (PENTA) model recreates vascular disorganization and incomplete repair after traumatic brain injury (TBI). By integrating endothelial, glial, neuronal, and immune components within a 3D scaffold, the platform enables time‐resolved analysis of neurovascular remodeling and provides a human‐relevant system ...
Daniel S. Hinrichsen, Sunghyun Jun, Colleen M. Arrasmith, Charitha C. Anamala, Mitchell D. Thielen, Anapaula Garcia, Volha Liaudanskaya   +6 more
wiley   +1 more source

Nanobody‐Conjugated Theranostic Prodrug Targeting αvβ3 Integrin Enables Precision Cancer Therapy With Real‐Time Imaging

Advanced Healthcare Materials, EarlyView.
The image shows a schematic form a nanobody‐conjugated theranostic prodrug (NBD) platform targeting tumor‐associated αvβ3 integrin. The NBD system integrates selective nanobody‐mediated tumor recognition, glutathione‐responsive disulfide cleavage for doxorubicin release, and aza‐BODIPY‐based near‐infrared fluorescence for real‐time imaging.
Sanu Karan, Hyunseung Lee, Rema Naskar, Mi Young Cho, Hye Sun Park, Eun Hee Han, Soumyadip Hore, Sun Hee Cho, Truc Ngoc Kim Lam, Taewoong Son, Tae Jung Park, Inkyu Hwang, Jonathan L. Sessler, Kwan Soo Hong   +13 more
wiley   +1 more source

Impact of time to antibiotics on survival in patients with severe sepsis or septic shock in whom early goal-directed therapy was initiated in the emergency department

, 2010
OBJECTIVE: To study the association between time to antibiotic administration and survival in patients with severe sepsis or septic shock in whom early goal-directed therapy was initiated in the emergency department.
Furia, Frances F., Mikkelsen, Mark E., Shofer, Frances S., Goyal, Munish, Gaieski, David F., Band, Roger A., Pines, Jesse M., Massone, Richard   +7 more
core  

Influence of the initial level of consciousness on early, goal-directed mobilization: a post hoc analysis

, 2019
Purpose: Early mobilization within 72 h of intensive care unit (ICU) admission improves functional status at hospital discharge. We aimed to assess the effectiveness of early, goal-directed mobilization in critically ill patients across a broad spectrum ...
Kasotakis G., Krebs F., Blobner M., Mazwi N., Eikermann M., Deng H., Bose S., Seifert C. L., Latronico N., Scheffenbichler F. T., Grabitz S. D., Houle T., Schaller S. J.   +12 more
core   +1 more source