Results 81 to 90 of about 11,648,449 (278)

Clinical Variability and Genotype Driven Outcomes in an International Cohort of 14 Pediatric FIG4 Patients

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Biallelic FIG4 variants classically cause distinct conditions characterized by peripheral neuropathy (Charcot‐Marie‐Tooth disease type 4J) or skeletal dysplasia (Yunis‐Varón syndrome). However, central nervous system involvement is increasingly recognized. The prevalence and specific characteristics of movement disorders within FIG4‐
Andrea Gangfuß, Vykuntaraju K. Gowda, Daniel Natera‐de Benito, Pinki Munot, Maria Vanegas, Alejandra Darling, Constanze Reutlinger, Laura Carrera‐Garcia, Gilbert Wunderlich, Heike Kölbel, Burkhard Stüve, David Muhmann, Lucía Monfort Belenguer, Diana‐Gabriela Barca, Viveka Santhosh Reddy C, Varunvenkat M. Srinivasan, Cristina Molina Anguita, Heinz Jungbluth, Hormos Salimi Dafsari, Thomas Rossor, Johann Böhm, Ulrike Schara‐Schmidt, Andreas Roos   +22 more
wiley   +1 more source

A Case Series of Emphysematous Pyelonephritis

Case Reports in Medicine, 2014
Introduction. Emphysematous pyelonephritis (EPN) is an uncommon infection characterized by gas in the renal parenchyma and surrounding tissues. It is rapidly progressive, requiring appropriate therapy to salvage the infected kidney.
Camelia Arsene, Abhijit Saste, Shankar Arul, Janee Mestrovich, Revark Kammo, Mohammed Elbashir, Gregory Berger   +6 more
doaj   +1 more source

Myostatin/Smad3 in Spinal Muscular Atrophy: Biomarkers of Disease Severity and Treatment Response

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Given the role of Myostatin (MSTN) in muscle homeostasis and its modulation by current spinal muscular atrophy (SMA) therapies, we investigated serum MSTN and, for the first time, its downstream effector Smad3 as candidate non‐invasive biomarkers in SMA patients undergoing disease‐modifying therapies (DMTs).
Giorgia Riolo, Claudia Dosi, Stefano Parravicini, Riccardo Zanin, Marta Cheli, Eleonora Giacopuzzi Grigoli, Amalia Canciello, Francesca Andreetta, Riccardo Masson, Silvia Bonanno, Stefania Marcuzzo, Lorenzo Maggi   +11 more
wiley   +1 more source

Perbandingan Nilai Analisis Gas Darah, Elektrolit, dan Laktat Setelah Pemberian Ringer Asetat Malat dengan Ringer Laktat untuk Early Goal Directed Therapy Pasien Sepsis

Jurnal Anestesi Perioperatif, 2018
Sepsis merupakan penyebab kedua tertinggi kematian di instalasi rawatan intensif dan merupakan 10 penyebab tertinggi kematian di seluruh dunia. Menurut Survival Sepsis Campaign 2012 penanganan awal pada pasien sepsis dengan pemberian cairan memberikan ...
Muhammad Fikri, Achsanuddin Hanafie, Nazaruddin Umar   +2 more
doaj   +1 more source

Race and Household Income Are Associated With Disease Outcomes in Pediatric Patients With Antineutrophil Cytoplasmic Antibody–Associated Vasculitis Hospitalized in the United States

Arthritis Care &Research, EarlyView.
Objective Race and household income impact outcomes in patients with rheumatic conditions; however, their role in pediatric antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV) remains poorly understood. We aimed to evaluate whether race and ethnicity and household income are associated with severe AAV disease and renal outcomes among
Roberto Alejandro Valdovinos, William Daniel Soulsby III, Emily von Scheven   +2 more
wiley   +1 more source

Goal-Directed Resuscitation for Patients with Early Septic Shock

, 2014
Goal-Directed Resuscitation for Patients with Early Septic ...
Alisa M Higgins (12059119), Peter A Cameron (13514155), Rinaldo Bellomo (982), Belinda D Howe (13477165), Anthony Delaney (20681), Steven AR Webb (15804716), Anna Holdgate (13477117), D James Cooper (13583407), Michael Bailey (62872), Patricia Williams (10862337), Sandra L Peake (13477150)   +10 more
core  

Correction of Hemodynamics with Hypertonic Sodium Chloride Solution in Critical Conditions

Общая реаниматология, 2007
Objective: to assess the capabilities of small-volume hypertonic infusion in the context of early goal-directed therapy for critical conditions in surgical patients.Subjects and methods.
P. S. Zhbannikov, A. V. Zabusov, D. V. Mikhin, A. N. Ganert   +3 more
doaj   +1 more source

Employment Trajectories of Patients With Systemic Lupus Erythematosus and Factors Driving Transitions Between States

Arthritis Care &Research, EarlyView.
Objective Systemic lupus erythematosus (SLE) significantly impacts employment capacity. This study aimed to investigate the impact of burden of disease activity, damage, and treatment on employment outcomes and transitions in patients with SLE. Methods Using data from a single center, we analyzed employment transitions, adjusted mean disease activity ...
Javier Mencia‐Ledo, Zahi Touma, Laura Whittall Garcia, Dafna D. Gladman, Behdin Nowrouzi‐Kia   +4 more
wiley   +1 more source

Early goal-directed treatment versus standard care in management of early septic shock: Meta-analysis of randomized trials

, 2016
Since the incorporation of the early hemodynamic resuscitation in septic shock according to the early goal-directed therapy (EGDT) protocol among the 6-hour resuscitation bundle of the Surviving Sepsis Campaign guidelines, a great debate has been raised ...
Ansaloni, Luca, Montori, Giulia, Coccolini, Federico, Catena, Fausto, Ceresoli, Marco, Sartelli, Massimo, Catena F., Ceresoli M, Catena F, Ansaloni L, Montori G, Ceresoli M., Ansaloni L., Sartelli M., Sartelli M, Coccolini F., Coccolini F, Montori G.   +17 more
core   +1 more source

Influence of Early Goal-Directed Therapy Targeting Capillary Refill Time, Serum Lactate or Base Deficit Levels on Morbidity and Mortality in Septic Shock Patients [PDF]

Zagazig University Medical Journal
Background: For patients with septic shock, early resuscitation is crucial in preventing organ failure and mortality. This study aimed to assess influence of early goal-directed therapy targeting capillary refill time, serum lactate, or base deficit ...
Mona El-Harrisi, Neven Gamil, Ayman Abdel Rahman, Aya Abbas   +3 more
doaj   +1 more source