Results 61 to 70 of about 104,595 (283)

Influence of early goal-directed therapy using arterial waveform analysis on major complications after high-risk abdominal surgery: study protocol for a multicenter randomized controlled superiority trial [PDF]

, 2014
Background: Early goal-directed therapy refers to the use of predefined hemodynamic goals to optimize tissue oxygen delivery in critically ill patients. Its application in high-risk abdominal surgery is, however, hindered by safety concerns and practical
Scheeren, Thomas, Michael Frank, de Waal, Eric, Leonard Montenij, Kruitwagen, Cas, Ardine de Wit, Paul van Beest, Cas Kruitwagen, Eric de Waal, Montenij, Leonard, van Beest, Paul, de Wit, Ardine, Frank, Michael, Wolfgang Buhre, Buhre, Wolfgang, Thomas Scheeren, Scheeren, Thomas; id_orcid   +16 more
core   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Impact of the implementation of an obstetric sepsis protocol on maternal and neonatal outcomes

Pregnancy
Objective Maternal sepsis is a leading cause of preventable maternal morbidity and mortality in the United States. We assessed the implementation of a standardized early‐goal‐directed sepsis care bundle on maternal and neonatal outcomes.
Ashley E. Shea, Christina T. Blanchard, Elizabeth B. Ausbeck, Rubymel J. Knupp, J. Michael Straughn Jr., Jeff M. Szychowski, Akila Subramaniam, Brian M. Casey, Alan T. Tita   +8 more
doaj   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Artificial Intelligence and Mental Well‐Being in Adult Education: Implications for Practice and Professional Responsibility

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Mental well‐being is central to adult learner success, yet many adult education institutions lack capacity to provide timely and accessible support. This article examines how artificial intelligence (AI) can strengthen mental health–adjacent supports in adult and continuing higher education, with attention to professional practice and ...
Adam L. McClain, Thomas Wade
wiley   +1 more source

Improving perioperative care in low-resource settings with goal-directed therapy: a narrative review

Brazilian Journal of Anesthesiology
Perioperative Goal-Directed Therapy (PGDT) has significantly showed to decrease complications and risk of death in high-risk patients according to numerous meta-analyses.
Suzana Margareth Lobo, João Manoel da Silva Junior, Luiz Marcelo Malbouisson   +2 more
doaj   +1 more source

Validity of a Wearable Digital Insole for Assessing Gait ON and OFF in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Gait impairment is a distinctive symptom of Parkinson's disease that negatively impact mobility. We assessed the validity of wearable digital insoles against a validated reference gait analysis system for measuring select gait characteristics in patients with Parkinson's disease. Methods A comparative analysis between digital insoles
Deborah A. Hall, Kimberly Kwei, Rolando J. Acosta, Bharatkumar Koyani, Erin Robertson, Pratyush Rai, Roland Barge, Emily Timm, Nicollette L. Purcell, Natasha Desai, Dhanesh Patel, Ana‐Maria Visoiu‐Knapp, Samuel Stuart, Rinol Alaj, Matthew F. Wipperman, Oren Levy, Joan A. O'Keefe   +16 more
wiley   +1 more source

Evolutive standard base excess and serum lactate level in severe sepsis and septic shock patients resuscitated with early goal-directed therapy: still outcome markers? [PDF]

Clinics, 2006
PURPOSE: To compare the evolution of standard base excess and serum lactate level between surviving and non surviving patients with severe sepsis and septic shock resuscitated with early goal-directed therapy. METHODS: This is a retrospective study in an
Marcelo Park, Luciano Cesar Pontes Azevedo, Alexandre Toledo Maciel, Vladimir Ribeiro Pizzo, Danilo Teixeira Noritomi, Luiz Monteiro da Cruz Neto   +5 more
doaj   +1 more source

Comparing the Effect of Semi‐Immersive Virtual Reality, Computerized Cognitive Training, and Traditional Rehabilitation on Cognitive Function in Multiple Sclerosis: A Randomized Clinical Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Cognitive impairment is a common non‐motor symptom in Multiple Sclerosis (MS), negatively affecting autonomy and Quality of Life (QoL). Innovative rehabilitation strategies, such as semi‐immersive virtual reality (VR) and computerized cognitive training (CCT), may offer advantages over traditional cognitive rehabilitation (TCR ...
Maria Grazia Maggio, Desiree Latella, Lilla Bonanno, Paulo Cezar Rocha dos Santos, Marcos Maldonado‐Díaz, Meir Plotnik, Rosaria De Luca, Angelo Quartarone, Rocco Salvatore Calabrò   +8 more
wiley   +1 more source

Comparison of Pulmonary Artery Catheter and Central Venous Catheter for Early Goal Directed Targeted Therapy in Sepsis and Septic Shock

, 2019
Objective: The aim of the present study was to compare the effect of the pulmonary artery catheterization (PAC) method and the central venous catheterization (CVC) method on hemodynamic and inflammatory parameters in early goal-directed therapy (EGDT)
Coskun, Ramazan, Elay, Gulseren, GÜNDOĞAN, KÜRŞAT, SUNGUR, MURAT, Guven, Muhammet   +4 more
core   +1 more source