Results 61 to 70 of about 11,648,449 (278)

Impact of the implementation of an obstetric sepsis protocol on maternal and neonatal outcomes

Pregnancy
Objective Maternal sepsis is a leading cause of preventable maternal morbidity and mortality in the United States. We assessed the implementation of a standardized early‐goal‐directed sepsis care bundle on maternal and neonatal outcomes.
Ashley E. Shea, Christina T. Blanchard, Elizabeth B. Ausbeck, Rubymel J. Knupp, J. Michael Straughn Jr., Jeff M. Szychowski, Akila Subramaniam, Brian M. Casey, Alan T. Tita   +8 more
doaj   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

A nationwide student survey on biochemistry learning resources in Italy

FEBS Open Bio, EarlyView.
We conducted a survey among Italian university students to investigate their preferred study materials for biochemistry. We then analyzed the collected data to identify these materials. This information may be valuable to the Biochemistry educational community. The graphical abstract was created with Claude (Opus 5.5; Anthropic, 2026).
Anna Marabotti, Ivano Eberini, Maria Luisa Genova, Francesca Mensitieri, Francesco Malatesta   +4 more
wiley   +1 more source

Improving perioperative care in low-resource settings with goal-directed therapy: a narrative review

Brazilian Journal of Anesthesiology
Perioperative Goal-Directed Therapy (PGDT) has significantly showed to decrease complications and risk of death in high-risk patients according to numerous meta-analyses.
Suzana Margareth Lobo, João Manoel da Silva Junior, Luiz Marcelo Malbouisson   +2 more
doaj   +1 more source

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source

Comparing the Effect of Semi‐Immersive Virtual Reality, Computerized Cognitive Training, and Traditional Rehabilitation on Cognitive Function in Multiple Sclerosis: A Randomized Clinical Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Cognitive impairment is a common non‐motor symptom in Multiple Sclerosis (MS), negatively affecting autonomy and Quality of Life (QoL). Innovative rehabilitation strategies, such as semi‐immersive virtual reality (VR) and computerized cognitive training (CCT), may offer advantages over traditional cognitive rehabilitation (TCR ...
Maria Grazia Maggio, Desiree Latella, Lilla Bonanno, Paulo Cezar Rocha dos Santos, Marcos Maldonado‐Díaz, Meir Plotnik, Rosaria De Luca, Angelo Quartarone, Rocco Salvatore Calabrò   +8 more
wiley   +1 more source

Time to antimicrobial therapy in septic shock patients treated with an early goal-directed resuscitation protocol: A post-hoc analysis of the ARISE trial

, 2021
Time to antimicrobial therapy in septic shock patients treated with an early goal-directed resuscitation protocol: A post-hoc analysis of the ARISE ...
D Haji (13424559), P Jones (7737215), K Grove (8279298), H Rodgers (7692659), J Vuat (13424565), V Bennett (13424523), A Williams (4236469), S Vij (13409025), J Fratzia (13477768), M Finnis (13477708), V Nanjayya (13424526), H Young (9645647), S Barrington-Onslow (13477753), C Gomersall (13477726), P McCracken (13424490), R Millar (9864101), G Braitberg (13424553), J Halkhoree (13477771), T Elderkin (13424481), E Hill (13372275), A Nichol (12113682), M Grummisch (13423935), SAR Webb (14450838), J Edington (13424538), A Harney (13477747), T Sara (13424634), K Milburn (7798907), A Van Berkel (13424550), J Dryburgh (13477756), P Kruger (13283253), T Coles (13424547), E Fulton (13477744), J Mehrtens (13424472), A Holdgate (13423875), F Sawtell (13477738), L Peak (13424535), M Okkonen (13344489), SL Peake (14450832), P Williams (9645629), I Jacobs (9862361), D Flemming (13424541), R Bellomo (11215281), A Delaney (13477711), G Eastwood (13299564), J Fletcher (9880310), AM Higgins (9995834), B O'Bree (13424556), S Johanson (13477732), K Schimanski (13477741), K Shepherd (7713410), D Stewart (9896981), H Connor (13358334), Neil Orford (13087728), J Board (13424493), A Tankel (13477759), E Wilkman (13342947), D Wilson (7749152), BD Howe (14450835), A Cross (12301412), E O'Brien (9896729), J Smith (7785128), S Treloar (9859718), PA Cameron (9607751), C McArthur (11215290), K Haji (13424562), I Mitchell (13300170), M Ragg (13424568), S Bolch (13424529), K Nand (13424628), V Pettilä (13342941), J Williams (7634615), D Ghelani (13424625), S Henderson (9872741), S Sutinen (13477765), S Scanlon (13477750), DJ Cooper (8916197), S McGloughlin (13352415), S Allsop (13164465), N Woodward (13477762), A Teo (9880331), C Graham (7771937), D Rajbhandari (13424613), EB Bulle (14450829), F Kerr (13424532), A Bone (13424478), J Myburgh (13424352), K Ryan (7792616), T Sandford (13477774), J Dennett (9881924), S Peake (13477714), VP Harjola (7761356), S Kelly (5785733)   +91 more
core  

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Evolutive standard base excess and serum lactate level in severe sepsis and septic shock patients resuscitated with early goal-directed therapy: still outcome markers? [PDF]

Clinics, 2006
PURPOSE: To compare the evolution of standard base excess and serum lactate level between surviving and non surviving patients with severe sepsis and septic shock resuscitated with early goal-directed therapy. METHODS: This is a retrospective study in an
Marcelo Park, Luciano Cesar Pontes Azevedo, Alexandre Toledo Maciel, Vladimir Ribeiro Pizzo, Danilo Teixeira Noritomi, Luiz Monteiro da Cruz Neto   +5 more
doaj   +1 more source

White Matter Microstructural Abnormalities in Neonatal Onset Genetic Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Recent evidence indicates that epilepsy is associated with abnormal white matter. If seizures alter white matter, then the impact upon network function, epileptogenesis, and cognition could be pronounced in neonates undergoing rapid developmental myelination. Neonates with epilepsy due to nonstructural genetic causes provide a unique
Amanda G. Sandoval Karamian, Tianjia Zhu, Hao Huang, Shavonne L. Massey, Mark P. Fitzgerald, Darshana Parikh, Arastoo Vossough, Ingo Helbig, Nicholas S. Abend   +8 more
wiley   +1 more source