Results 41 to 50 of about 104,595 (283)

Personalised anaesthesia, arterial blood gases and tissue hypoxia: modulating postoperative regeneration and healing [PDF]

Scripta Medica
The fundamental limiting factor of major surgery is the body's ability to regenerate and heal tissue after it has been operated on, but this process must take its own course.
Jayaram Jacynta, Amin Baig Atif, Thunder Oo Aey, Hoo Phone Mynt, Zaw Win Kyaw, Thein Khin Hla Hla, Chopra Shivani, Junapudi Sunil, Chopra Hitesh   +8 more
doaj   +1 more source

Treatment Guidelines of Severe Sepsis and Septic Shock [PDF]

Journal of Neurocritical Care, 2015
Severe sepsis and septic shock are common health care problem with high mortality. In 2001, Early goal directed therapy was introduced, early appropriate therapy impact on the outcome. In 2012, the “Surviving Sepsis Campaign: International Guidelines for
Soonyoung Park, Sang-Bum Hong
doaj   +1 more source

Goal-directed haemodynamic therapy during elective total hip arthroplasty under regional anaesthesia.

, 2011
INTRODUCTION: Total hip replacement is one of the most commonly performed major orthopaedic operations. Goal-directed therapy (GDT) using haemodynamic monitoring has previously demonstrated outcome benefits in high-risk surgical patients under general ...
Michele Divella, Della Rocca, G, Nicola Langiano, Nicola Fasano, COSTA, Maria Gabriella, DELLA ROCCA, Giorgio, Fasano, N, Maria G Costa, Cecconi, M, Maurizio Cecconi, Divella, M, RHODES A, Rhodes, A, DIVELLA M, Costa, MG, Giorgio Rocca, FASANO N, CECCONI M, LANGIANO N, Langiano, N, Andrew Rhodes   +20 more
core   +1 more source

Identifying which septic patients have increased mortality risk using severity scores: a cohort study [PDF]

, 2014
Background: Early aggressive therapy can reduce the mortality associated with severe sepsis but this relies on prompt recognition, which is hindered by variation among published severity criteria. Our aim was to test the performance of different severity
Marwick, Charis A; id_orcid, Evans, Josie, Peter G Davey, Pringle, Jan E C, Pringle, Jan Ec, Guthrie, Bruce, Josie MM Evans, McLeod, Shaun R, Shaun R McLeod, Marwick, Charis, Bruce Guthrie, Charis A Marwick, Davey, Peter G, Jan EC Pringle, Evans, Josie Mm   +14 more
core   +1 more source

Key components of early goal directed therapy.

, 2019
Key components of early goal directed therapy.
Rujipat Samransamruajkit (6470519), Thansinee Saetae (6470516), Krit Pongpirul (5735576)   +2 more
core   +1 more source

Early Goal-Directed Therapy in Severe Sepsis and Septic Shock: A Contemporary Review of the Literature

, 2008
Purpose of review: Aggressive approaches to acute diseases such as acute myocardial infarction, trauma, and stroke have improved outcomes. Early goal-directed therapy for severe sepsis and septic shock represents a similar approach.
Coba, Victor, Whitmill, Melissa L., Rivers, Emanuel   +2 more
core   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Does early goal directed therapy in sepsis still hold relevance in low and middle-income countries?

, 2017
The efficacy of early goal directed therapy in improving outcomes has been questioned in few recent studies. But, does that hold true for low and middle income countries like Nepal?
Apurb Sharma, Diptesh Aryal
core   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source