Results 51 to 60 of about 11,648,449 (278)

New strategies in multiple organ dysfunction syndrometherapy for sepsis [PDF]

Srpski Arhiv za Celokupno Lekarstvo, 2005
Despite more than 20 years of extensive research, sepsis and/or trauma induced multiple organ dysfunction syndrome (MODS) remain the chief cause of death in intensive care units, with mortality rates between 30% and 80%. Early goal-directed therapy (EGDT)
Šurbatović Maja, Radaković Sonja, Jovanović Krsta, Romić Predrag   +3 more
doaj   +1 more source

Differences in NT‐proBNP Response and Prognosis in Men and Women With Heart Failure With Reduced Ejection Fraction

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background NT‐proBNP (N‐terminal pro‐B‐type natriuretic peptide) is a prognostic biomarker in heart failure (HF) with reduced ejection fraction. However, it is unclear whether there is a sex difference in NT‐proBNP response and whether the therapeutic ...
Melissa A. Daubert, Eric Yow, Huiman X. Barnhart, Ileana L. Piña, Tariq Ahmad, Eric Leifer, Lawton Cooper, Patrice Desvigne‐Nickens, Mona Fiuzat, Kirkwood Adams, Justin Ezekowitz, David J. Whellan, James L. Januzzi, Christopher M. O’Connor, G. Michael Felker   +14 more
doaj   +1 more source

Mitochondrial translation and coordinated cytosolic translation in metabolic homeostasis and disease

FEBS Letters, EarlyView.
Mitochondrial function depends on coordinated protein production from the nuclear and mitochondrial genomes. This review highlights how cytosolic and mitochondrial translation, mRNA localization, protein import, and respiratory complex assembly are integrated to maintain mitochondrial proteostasis and function.
Boseon Kim, Thi Thanh Mai Tran, Nakyung Kang, Min‐Woo Lee, Mihye Lee   +4 more
wiley   +1 more source

Early Goal Directed Therapy: Do We Reach the End of Road?

Archives of Anesthesia and Critical Care, 2016
No ...
Ata Mahmoodpoor, Samad EJ Golzari
doaj  

The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection

Molecular Oncology, EarlyView.
Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński, Krzysztof Pastuszak, Anna Samelak‐Czajka, Zuzanna Cemka, Paulina Jackowiak, Tomasz Stefaniak, Sylwia Łapińska‐Szumczyk, Jacek Jassem, Anna J. Żaczek, Matthew T. Rondina, Myron G. Best, Sjors G. J. G. In 't Veld, Anna Supernat   +12 more
wiley   +1 more source

Overcoming platinum resistance by the disulfiram metabolite CuET in novel preclinical models of human carcinomas

Molecular Oncology, EarlyView.
Cisplatin‐resistant cancer cells survive DNA‐damaging platinum‐based treatment yet remain sensitive to CuET‐induced proteotoxic stress. The distinct mechanism of action allows CuET to overcome and eliminate cisplatin‐resistant tumour cells, unless highly expressed metallothioneins (MTs) interfere with CuET, thereby highlighting MT levels as candidate ...
Stefanos Arampatzis, Tereza Buchtová, Jirina Bartkova, Marie Lund Bay, Christoffer Lynge Halvorsen, Zuzana Machacova, Zdenek Skrott, Martin Mistrik, Ekaterina Dulina, Miguel Andujar‐Sanchez, Estrid Høgdall, Tine Henrichsen Schnack, Claus Høgdall, Berit Jul Mosgaard, Marie Boennelycke, Jacob Brink Laursen, Allan Jensen, Susanne K. Kjær, Tuula Kallunki, Robert Strauss, Jiri Bartek   +20 more
wiley   +1 more source

Early Goal-Directed Therapy in Severe Sepsis and Septic Shock: A Contemporary Review of the Literature

, 2008
Purpose of review: Aggressive approaches to acute diseases such as acute myocardial infarction, trauma, and stroke have improved outcomes. Early goal-directed therapy for severe sepsis and septic shock represents a similar approach.
Coba, Victor, Whitmill, Melissa L., Rivers, Emanuel   +2 more
core   +1 more source

Goal-directed cardiopulmonary resuscitation for refractory out-of-hospital cardiac arrest in the emergency Department: A feasibility study

Resuscitation Plus, 2021
Aim: To describe the feasibility of prospective measurement of intra-arrest diastolic blood pressure (DBP) and goal-directed treatment of refractory out-of-hospital cardiac arrest (OHCA) in the emergency department (ED).
Byron C. Drumheller, Joseph Pinizzotto, Ryan C. Overberger, Erin E. Sabolick   +3 more
doaj   +1 more source

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

Molecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi, Sang‐Hyeon Yoo, Ki‐Jong Rhee   +2 more
wiley   +1 more source

Comparison of Pulmonary Artery Catheter and Central Venous Catheter for Early Goal Directed Targeted Therapy in Sepsis and Septic Shock

, 2019
Objective: The aim of the present study was to compare the effect of the pulmonary artery catheterization (PAC) method and the central venous catheterization (CVC) method on hemodynamic and inflammatory parameters in early goal-directed therapy (EGDT)
Coskun, Ramazan, Elay, Gulseren, GÜNDOĞAN, KÜRŞAT, SUNGUR, MURAT, Guven, Muhammet   +4 more
core   +1 more source