Results 51 to 60 of about 104,595 (283)

New strategies in multiple organ dysfunction syndrometherapy for sepsis [PDF]

Srpski Arhiv za Celokupno Lekarstvo, 2005
Despite more than 20 years of extensive research, sepsis and/or trauma induced multiple organ dysfunction syndrome (MODS) remain the chief cause of death in intensive care units, with mortality rates between 30% and 80%. Early goal-directed therapy (EGDT)
Šurbatović Maja, Radaković Sonja, Jovanović Krsta, Romić Predrag   +3 more
doaj   +1 more source

Differences in NT‐proBNP Response and Prognosis in Men and Women With Heart Failure With Reduced Ejection Fraction

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background NT‐proBNP (N‐terminal pro‐B‐type natriuretic peptide) is a prognostic biomarker in heart failure (HF) with reduced ejection fraction. However, it is unclear whether there is a sex difference in NT‐proBNP response and whether the therapeutic ...
Melissa A. Daubert, Eric Yow, Huiman X. Barnhart, Ileana L. Piña, Tariq Ahmad, Eric Leifer, Lawton Cooper, Patrice Desvigne‐Nickens, Mona Fiuzat, Kirkwood Adams, Justin Ezekowitz, David J. Whellan, James L. Januzzi, Christopher M. O’Connor, G. Michael Felker   +14 more
doaj   +1 more source

A pragmatic multi-centre randomised controlled trial of fluid loading in high-risk surgical patients undergoing major elective surgery : the FOCCUS study [PDF]

, 2011
Peer ...
Campbell, MK, Stott, Stephen A., Seonaidh C Cotton, Daniela Rae, Cook, Jonathan, Rae, Daniela, Elders, Andrew, Grant, Adrian, Brian H Cuthbertson, Grant, A, Stott, Stephen A, Cook, J, Addison, Jennifer, Campbell, Marion K, Stephen A Stott, Campbell, Marion K., Hernández, R, Stott, SA, Cuthbertson, Brian H., Kinsella, John, Adrian Grant, Boyers, Dwayne, David Alcorn, null null, Alcorn, D, Kinsella, J, Cuthbertson, Brian H, Boyers, D, Norrie, John, Dwayne Boyers, Andrew Elders, The FOCCUS study group, Hernández, Rodolfo, Elders, A, Rodolfo Hernández, Julie Brittenden, Addison, J, Brittenden, Julie, Alcorn, David, Cotton, SC, John Norrie, Rae, D, Brittenden, J, Cotton, Seonaidh C, Cuthbertson, BH, Cotton, Seonaidh C., Marion K Campbell, Norrie, J, Jennifer Addison, John Kinsella, Jonathan Cook   +50 more
core   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

"I Can't Walk!" Acute Thrombosis of Descending Aorta Causing Paraplegia

Western Journal of Emergency Medicine, 2013
A 50-year-old man presented to the emergency department (ED) with acute, bilateral lower extremity weakness and loss of sensation, as well as absent pulses bilaterally.
Matthew L Mitchell, Elif Yuceby, Mitchell R Weaver, A Kathrin Jaehne, Emanuel P Rivers   +4 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Early Goal Directed Therapy: Do We Reach the End of Road?

Archives of Anesthesia and Critical Care, 2016
No ...
Ata Mahmoodpoor, Samad EJ Golzari
doaj  

Goal-directed cardiopulmonary resuscitation for refractory out-of-hospital cardiac arrest in the emergency Department: A feasibility study

Resuscitation Plus, 2021
Aim: To describe the feasibility of prospective measurement of intra-arrest diastolic blood pressure (DBP) and goal-directed treatment of refractory out-of-hospital cardiac arrest (OHCA) in the emergency department (ED).
Byron C. Drumheller, Joseph Pinizzotto, Ryan C. Overberger, Erin E. Sabolick   +3 more
doaj   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source