Is subjective social status a more important determinant of health than objective social status? Evidence from a prospective observational study of Scottish men [PDF]
, 2005 Both subjective and objective measures of lower social position have been shown to be associated with poorer health. A psychosocial, as opposed to material, aetiology of health inequalities predicts that subjective social status should be a stronger ...
Davey Smith, G. +3 more
core +1 more source
Targeting the Stress System During Gestation: Is Early Handling a Protective Strategy for the Offspring? [PDF]
, 2020 The perinatal window is a critical developmental time when abnormal gestational stimuli may alter the development of the stress system that, in turn, influences behavioral and physiological responses in the newborns.
Brancato, Anna +3 more
core +3 more sources
Early life stress alters transcriptomic patterning across reward circuitry in male and female mice
Nature Communications, 2019 Abuse, neglect, and other forms of early life stress (ELS) significantly increase risk for psychiatric disorders including depression. In this study, we show that ELS in a postnatal sensitive period increases sensitivity to adult stress in female mice ...
C. Peña +12 more
semanticscholar +1 more source
Microglial Function in the Effects of Early-Life Stress on Brain and Behavioral Development
Journal of Clinical Medicine, 2020 The putative effects of early-life stress (ELS) on later behavior and neurobiology have been widely investigated. Recently, microglia have been implicated in mediating some of the effects of ELS on behavior.
Clarissa Catale +3 more
semanticscholar +1 more source
Hippocampal neuroplasticity induced by early-life stress: functional and molecular aspects. [PDF]
, 2006 Whereas genetic factors contribute crucially to brain function, early-life events, including stress, exert long-lasting influence on neuronal function. Here, we focus on the hippocampus as the target of these early-life events because of its crucial role
Baram, Tallie Z +2 more
core +1 more source
Reward-related neural correlates of early life stress in school-aged children
Developmental Cognitive Neuroscience, 2021 Objectives: Early life stress likely contributes to dysfunction in neural reward processing systems. However, studies to date have focused almost exclusively on adolescents and adults, measured early life stress retrospectively, and have often failed to ...
Nicholas M. Morelli +7 more
doaj +1 more source
Maternal separation on postnatal stress in rats induces long-lasting changes on neurochemical, behavioural and genome responses [PDF]
, 2013 Early stress in life results in long-lasting effects in many neurotransmitter and neuroendocrine systems of the brain. Maternal separation (MS) is used an early life stressor that causes profound neurochemical and behavioural changes in the pups that ...
Acosta, Gabriela Beatriz
core +1 more source
Early handling and repeated cross-fostering have opposite effect on mouse emotionality [PDF]
, 2015 Early life events have a crucial role in programming the individual phenotype and exposure to traumatic experiences during infancy can increase later risk for a variety of neuropsychiatric conditions, including mood and anxiety disorders.
Battaglia, M +6 more
core +2 more sources
Psychoneuroendocrinology, 2020 There is a growing emphasis on the role of the microbiota-gut-brain axis as modulator of host behaviour and as therapeutic target for neuropsychiatric disorders.
Francisco Donoso +9 more
semanticscholar +1 more source
Telomeres and Early-Life Stress: An Overview [PDF]
Biological Psychiatry, 2013 The long-term sequelae of adverse early-life experiences have long been a focus in psychiatry, with a historic neurobiological emphasis on physiological systems that are demonstrably stress-responsive, such as the hypothalamic-pituitary-adrenal axis and neuroimmune function.
Lawrence H, Price +4 more
openaire +2 more sources