Results 41 to 50 of about 920,236 (292)

Early life stress concept: introduction

European Journal of Psychotraumatology, 2012
Rationale/statement of the problem : Stressful experiences during early life can remodel brain circuitry underlying behavioral adaptation with consequences for resilience and vulnerability to emotional and cognitive disorders. At least in the rodent this
E. Ronald de Kloet, Nikolaos P. Daskalakis   +1 more
doaj   +1 more source

Traumatic Injury to the Developing Brain: Emerging Relationship to Early Life Stress

Frontiers in Neurology, 2021
Despite the high incidence of brain injuries in children, we have yet to fully understand the unique vulnerability of a young brain to an injury and key determinants of long-term recovery.
Kaila N. Parker, Kaila N. Parker, Michael H. Donovan, Michael H. Donovan, Kylee Smith, Kylee Smith, Linda J. Noble-Haeusslein, Linda J. Noble-Haeusslein   +7 more
doaj   +1 more source

Early Life Stress, Nicotinic Acetylcholine Receptors and Alcohol Use Disorders

, 2015
Stress is a major driving force in alcohol use disorders (AUDs). It influences how much one consumes, craving intensity and whether an abstinent individual will return to harmful alcohol consumption. We are most vulnerable to the effects of stress during
Selena E. Bartlett, Joan Holgate, Selena Bartlett, Bartlett, Selena E., Holgate, Joan Y., Joan Y. Holgate   +5 more
core   +1 more source

Insecure attachment during infancy predicts greater amygdala volumes in early adulthood [PDF]

, 2014
Background The quality of the early environment is hypothesized to be an influence on morphological development in key neural areas related to affective responding, but direct evidence to support this possibility is limited.
Pliatsikas, C., Johnstone, Tom, Halligan, S.L., Moutsiana, C., Goodyer, I., Goodyer, Ian, Moutsiana, Christina, Murray, Lynne, Halligan, Sarah L., Cooper, Peter J., Johnstone, T., Fearon, P., Cooper, P.J., Murray, L., Fearon, Pasco, Pliatsikas, Christos   +15 more
core   +1 more source

Early Life Stress, Hormones, and Neurodevelopmental Disorders

Hormone Research in Paediatrics, 2022
Background: Early life stress (ELS) describes a broad spectrum of adverse and stressful prenatal events, namely, prenatal maternal stress (PMS), or early postnatal events, which can have detrimental long-term influences on the physiology, cognition, and behavior of an individual. There is abundant evidence indicating that ELS exerts its lasting effects
Gerasimos Makris, Anna Eleftheriades, Panagiota Pervanidou   +2 more
openaire   +3 more sources

Cortisol diurnal rhythm and stress reactivity in male adolescents with early-onset or adolescence-onset conduct disorder [PDF]

, 2008
Background: Previous studies have reported lower basal cortisol levels and reduced cortisol responses to stress in children and adolescents with conduct disorder (CD). It is not known whether these findings are specific to early-onset CD.
Stephanie H.M. van Goozen, Sarah J. Stollery, Gardiner, Julian, van Goozen, Stephanie HM, van Goozen, Stephanie H.M., Van Goozen, Stephanie Helena Maria, Graeme Fairchild, Stollery, Sarah J., Goodyer, Ian M, Herbert, Joe, Stollery, Sarah J, Brown, Jamie, Goodyer, Ian M., Goodyer, Ian M., Ian M. Goodyer, Julian Gardiner, Stollery, Sarah J.., Joe Herbert, Jamie Brown, Fairchild, Graeme   +19 more
core   +1 more source

Time Toxicity in Wilms Tumor: Quantifying the Burden of Healthcare Interaction in the First Year After Diagnosis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Wilms tumor (WT) treatment imposes a significant time burden on patients and their families. Time toxicity is a patient‐centered metric that quantifies the burden of healthcare interaction. We sought to define time toxicity in the first year after diagnosis of WT and hypothesized that it would increase as tumor stage and treatment ...
Caleb Q. Ashbrook, Veerain Gupta, Nicholas J. Clark, Vijay Rings, Lauren E. Corona, Douglass B. Clayton, Daniel J. Benedetti   +6 more
wiley   +1 more source

Suppressed Calbindin Levels in Hippocampal Excitatory Neurons Mediate Stress-Induced Memory Loss

Cell Reports, 2017
Summary: Calbindin modulates intracellular Ca2+ dynamics and synaptic plasticity. Reduction of hippocampal calbindin levels has been implicated in early-life stress-related cognitive disorders, but it remains unclear how calbindin in distinct populations
Ji-Tao Li, Xiao-Meng Xie, Jing-Ying Yu, Ya-Xin Sun, Xue-Mei Liao, Xing-Xing Wang, Yun-Ai Su, Yi-Jun Liu, Mathias V. Schmidt, Xiao-Dong Wang, Tian-Mei Si   +10 more
doaj   +1 more source

Early and Later Life Stress Alter Brain Activity and Sleep in Rats [PDF]

, 2013
Exposure to early life stress may profoundly influence the developing brain in lasting ways. Neuropsychiatric disorders associated with early life adversity may involve neural changes reflected in EEG power as a measure of brain activity and disturbed ...
Bjørn Bjorvatn, Pallesen, Ståle, Robert Murison, Janne Grønli, Jellestad, Finn Konow, Anne Marita Milde, Murison, Robert, Grønli, Janne, Mrdalj, Jelena, Ståle Pallesen, Milde, Anne Marita, Reidun Ursin, Finn Konow Jellestad, Ursin, Reidun, Bjorvatn, Bjørn, Jelena Mrdalj   +15 more
core   +1 more source

The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli, Seth Rotz, Masatoshi Takagi, Richa Sharma   +3 more
wiley   +1 more source