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Early life stress and psychopharmacology [PDF]

Psychopharmacology, 2011
The concept of early life stress (ELS) has long been a central focus in clinical psychiatry and psychology, owing in no small part to the primacy of this concept in psychoanalytic theory. Perhaps in response to that legacy, both clinical and preclinical biologically oriented researchers have become increasingly invested in understanding the adult ...
Lawrence H, Price, Thomas, Steckler
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Early-life adversity and edentulism among Chinese older adults

BMC Oral Health, 2022
Background Emerging evidence indicate the relationship between ELA with oral health problems. However, most focus on single types of adversity. The association of cumulative ELA with edentulism, the final marker of disease burden for oral health, remains
Ziqing Tang, Chuanlong Huang, Yang Li, Ying Sun, Xin Chen   +4 more
doaj   +1 more source

Early-life stress and neurometabolites of the hippocampus [PDF]

Brain Research, 2010
We tested the hypothesis that early life stress would persistently compromise neuronal viability of the hippocampus of the grown nonhuman primate. Neuronal viability was assessed through ascertainment of N-acetyl aspartate (NAA)-an amino acid considered reflective of neuronal density/functional integrity-using in vivo proton magnetic resonance ...
Jeremy D, Coplan, Sanjay J, Mathew, Chadi G, Abdallah, Xiangling, Mao, John G, Kral, Eric L P, Smith, Leonard A, Rosenblum, Tarique D, Perera, Andrew J, Dwork, Patrick R, Hof, Jack M, Gorman, Dikoma C, Shungu   +11 more
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Telomeres and Early-Life Stress: An Overview [PDF]

Biological Psychiatry, 2013
The long-term sequelae of adverse early-life experiences have long been a focus in psychiatry, with a historic neurobiological emphasis on physiological systems that are demonstrably stress-responsive, such as the hypothalamic-pituitary-adrenal axis and neuroimmune function.
Lawrence H, Price, Hung-Teh, Kao, Darcy E, Burgers, Linda L, Carpenter, Audrey R, Tyrka   +4 more
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Epigenetic Programming by Early-Life Stress [PDF]

, 2018
Studies show that adverse conditions during early life can increase risks of developing mood disorders later in life. It is currently hypothesized that levels of environmental adversity in this early developmental period are able to shape the experience-dependent maturation of stress-regulating pathways leading to long-lasting alterations in stress ...
Reema Abdulrahman S, Alyamani, Chris, Murgatroyd   +1 more
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Early life maternal separation induces sex-specific antidepressant-like responses but has minimal effects on adult stress susceptibility in mice

Frontiers in Behavioral Neuroscience, 2022
Early life stress is known to increase the risk of depression and anxiety disorders, which are highly prevalent conditions that disproportionately affect women.
Brittany J. Baugher, Benjamin D. Sachs
doaj   +1 more source

Parent-child interactions in early life mediating association between prenatal maternal stress and autistic-like behaviors among preschoolers

, 2023
A range of studies have shown that prenatal maternal stress (PNMS) exposure is associated with offspring autistic-like behaviors, however the potential pathways remain unexplored.
Wei-Qing Chen, Xiang-Yu Hou, Jing-Yi Chen, Sun, Deng-Li, Deng-Li Sun, Ying-Jie Chen, Chuan-an Wu, Yin, Xiao-Na, Yang, Gui-You, Hou, Xiang-Yu, Guo-Min Wen, Strodl, Esben, Li-Hua Huang, Chen, Wei-Qing, Gui-You Yang, Xian, Dan-Xia, Wu, Chuan-an, Wen, Guo-Min, Esben Strodl, Huang, Li-Hua, Xiao-Na Yin, Dan-Xia Xian, Chen, Jing-Yi, Chen, Ying-Jie   +23 more
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The psychopathological potential of early life stress [PDF]

The World Journal of Biological Psychiatry, 2020
In the second decade of the twenty-first century, there has been an eruption of studies on the pathogenic role of stress in early life, named also ‘early life adversity’ or ‘childhood trauma’, in p...
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Daily life stress and the cortisol awakening response: testing the anticipation hypothesis [PDF]

, 2012
The cortisol awakening response (CAR) is a distinct facet of the circadian cortisol rhythm associated with various health conditions and risk factors.
Schlotz, Wolff, Daniel J Powell, Wolff Schlotz, Schlotz, W., Powell, Daniel J., Powell, D., Powell Daniel J., Schlotz Wolff, Powell, Daniel J   +8 more
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The interplay of early-life stress, nutrition and immune activation programs adult hippocampal structure and function

Frontiers in Molecular Neuroscience, 2015
Early-life adversity increases the vulnerability to develop psychopathologies and cognitive decline later in life. This association is supported by clinical and preclinical studies.
Lianne eHoeijmakers, Paul eLucassen, Aniko eKorosi   +2 more
doaj   +1 more source