Results 11 to 20 of about 898,554 (254)
Early-life stress sensitizes response to future stress: Evidence and mechanisms [PDF]
Neurobiology of StressEarly-life stress sensitizes individuals to additional stressors and increases lifetime risk for mood and anxiety disorders. Research in both human populations and rodent models of early-life stress have sought to determine how different types of ...
Catherine Jensen Peña
doaj +2 more sources
Early life stress and psychopharmacology [PDF]
Psychopharmacology, 2011 The concept of early life stress (ELS) has long been a central focus in clinical psychiatry and psychology, owing in no small part to the primacy of this concept in psychoanalytic theory. Perhaps in response to that legacy, both clinical and preclinical biologically oriented researchers have become increasingly invested in understanding the adult ...
Lawrence H, Price, Thomas, Steckler
openaire +2 more sources
Early-life adversity and edentulism among Chinese older adults
BMC Oral Health, 2022 Background Emerging evidence indicate the relationship between ELA with oral health problems. However, most focus on single types of adversity. The association of cumulative ELA with edentulism, the final marker of disease burden for oral health, remains
Ziqing Tang +4 more
doaj +1 more source
Early-life stress and neurometabolites of the hippocampus [PDF]
Brain Research, 2010 We tested the hypothesis that early life stress would persistently compromise neuronal viability of the hippocampus of the grown nonhuman primate. Neuronal viability was assessed through ascertainment of N-acetyl aspartate (NAA)-an amino acid considered reflective of neuronal density/functional integrity-using in vivo proton magnetic resonance ...
Jeremy D, Coplan +11 more
openaire +2 more sources
Telomeres and Early-Life Stress: An Overview [PDF]
Biological Psychiatry, 2013 The long-term sequelae of adverse early-life experiences have long been a focus in psychiatry, with a historic neurobiological emphasis on physiological systems that are demonstrably stress-responsive, such as the hypothalamic-pituitary-adrenal axis and neuroimmune function.
Lawrence H, Price +4 more
openaire +2 more sources
Frontiers in Behavioral Neuroscience, 2022 Early life stress is known to increase the risk of depression and anxiety disorders, which are highly prevalent conditions that disproportionately affect women.
Brittany J. Baugher, Benjamin D. Sachs
doaj +1 more source
Epigenetic Programming by Early-Life Stress [PDF]
, 2018 Studies show that adverse conditions during early life can increase risks of developing mood disorders later in life. It is currently hypothesized that levels of environmental adversity in this early developmental period are able to shape the experience-dependent maturation of stress-regulating pathways leading to long-lasting alterations in stress ...
Reema Abdulrahman S, Alyamani +1 more
openaire +2 more sources
The psychopathological potential of early life stress [PDF]
The World Journal of Biological Psychiatry, 2020 In the second decade of the twenty-first century, there has been an eruption of studies on the pathogenic role of stress in early life, named also ‘early life adversity’ or ‘childhood trauma’, in p...
openaire +2 more sources
Frontiers in Molecular Neuroscience, 2015 Early-life adversity increases the vulnerability to develop psychopathologies and cognitive decline later in life. This association is supported by clinical and preclinical studies.
Lianne eHoeijmakers +2 more
doaj +1 more source
Effect of Early Life Stress on the Epigenetic Profiles in Depression
Frontiers in Cell and Developmental Biology, 2020 Depression is one of the most common mental disorders and has caused an overwhelming burden on world health. Abundant studies have suggested that early life stress may grant depressive-like phenotypes in adults. Childhood adversities that occurred in the
Ming Li +6 more
doaj +1 more source