Results 11 to 20 of about 13,943,232 (281)

Early-life stress sensitizes response to future stress: Evidence and mechanisms

Neurobiology of Stress
Early-life stress sensitizes individuals to additional stressors and increases lifetime risk for mood and anxiety disorders. Research in both human populations and rodent models of early-life stress have sought to determine how different types of ...
Catherine Jensen Peña
doaj   +3 more sources

The relationship between early life stress and microstructural integrity of the corpus callosum in a non-clinical population

Neuropsychiatric Disease and Treatment, 2008
Robert Paul1, Lorrie Henry2, Stuart M Grieve3, Thomas J Guilmette2,4, Raymond Niaura4, Richard Bryant5, Steven Bruce1, Leanne M Williams3,6, Clark C Richard7, Ronald A Cohen4, Evian Gordon3,71University of Missouri, St. Louis, St.
Robert Paul, Lorrie Henry, Stuart M Grieve, Thomas J Guilmette, Raymond Niaura, et al   +5 more
doaj   +1 more source

Persistent open chromatin state in early-life stress-activated cells of the VTA [PDF]

Scientific Reports
Early-life stress sensitizes individuals to subsequent stressors to increase lifetime risk for psychiatric disorders. Within the ventral tegmental area (VTA), a mesolimbic brain region implicated in stress response and mental health, early-life stress ...
Rebekah L. Rashford, Michael DeBerardine, Shu Dan, Shannon N. Bennett, Catherine Jensen Peña   +4 more
doaj   +2 more sources

The Role of early-life psychological factors in the development of chronic disease: a longitudinal analysis applied to the onset of cancer, diabetes, and asthma in mid-life. [PDF]

Background: There is increasing evidence that psychological factors such as stress and depression might have an influence in the onset of many physical illnesses, but less is known about their effect from early life. This study is an epidemiological life-
Ogollah, Reuben Odongo
core   +9 more sources

Early life stress and psychopharmacology [PDF]

Psychopharmacology, 2011
The concept of early life stress (ELS) has long been a central focus in clinical psychiatry and psychology, owing in no small part to the primacy of this concept in psychoanalytic theory. Perhaps in response to that legacy, both clinical and preclinical biologically oriented researchers have become increasingly invested in understanding the adult ...
Lawrence H, Price, Thomas, Steckler
openaire   +2 more sources

Early-life adversity and edentulism among Chinese older adults

BMC Oral Health, 2022
Background Emerging evidence indicate the relationship between ELA with oral health problems. However, most focus on single types of adversity. The association of cumulative ELA with edentulism, the final marker of disease burden for oral health, remains
Ziqing Tang, Chuanlong Huang, Yang Li, Ying Sun, Xin Chen   +4 more
doaj   +1 more source

Early-life stress and neurometabolites of the hippocampus [PDF]

Brain Research, 2010
We tested the hypothesis that early life stress would persistently compromise neuronal viability of the hippocampus of the grown nonhuman primate. Neuronal viability was assessed through ascertainment of N-acetyl aspartate (NAA)-an amino acid considered reflective of neuronal density/functional integrity-using in vivo proton magnetic resonance ...
Jeremy D, Coplan, Sanjay J, Mathew, Chadi G, Abdallah, Xiangling, Mao, John G, Kral, Eric L P, Smith, Leonard A, Rosenblum, Tarique D, Perera, Andrew J, Dwork, Patrick R, Hof, Jack M, Gorman, Dikoma C, Shungu   +11 more
openaire   +2 more sources

Reduced resistance to oxidative stress during reproduction as a cost of early-life stress [PDF]

, 2015
This study was funded by a BBSRC David Phillips Research Fellowship to K.A. Spencer.Stress exposure during early-life development can have long-term consequences for a variety of biological functions including oxidative stress.
Zimmer, C., Spencer, K.A.
core   +1 more source

Telomeres and Early-Life Stress: An Overview [PDF]

Biological Psychiatry, 2013
The long-term sequelae of adverse early-life experiences have long been a focus in psychiatry, with a historic neurobiological emphasis on physiological systems that are demonstrably stress-responsive, such as the hypothalamic-pituitary-adrenal axis and neuroimmune function.
Lawrence H, Price, Hung-Teh, Kao, Darcy E, Burgers, Linda L, Carpenter, Audrey R, Tyrka   +4 more
openaire   +2 more sources

The psychopathological potential of early life stress [PDF]

The World Journal of Biological Psychiatry, 2020
In the second decade of the twenty-first century, there has been an eruption of studies on the pathogenic role of stress in early life, named also ‘early life adversity’ or ‘childhood trauma’, in p...
openaire   +2 more sources