Results 61 to 70 of about 2,848,670 (398)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

General Psychopathology and Dysregulation Profile in a Longitudinal Community Sample: Stability, Antecedents and Outcomes. [PDF]

, 2020
The general factor of psychopathology (GP, or p factor) and the Dysregulation Profile (DP) are two conceptually similar, but independently developed approaches to understand psychopathology.
Belsky, Jay, Deković, Maja, Deutz, Marike HF, Geeraerts, Sanne B, Patalay, Praveetha, Prinzie, Peter, van Baar, Anneloes L   +6 more
core   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

26Al/10Be Age of Peking Man [PDF]

, 2008
The chronological position of Peking Man, or Homo erectus pekinensis, has long been pursued, but has remained problematic due to lack of a suitable dating method^1-7^.
Bin Gao, Darryl Granger, Guanjun Shen, Xing Gao   +3 more
core   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Linear Growth through 12 Years is Weakly but Consistently Associated with Language and Math Achievement Scores at Age 12 Years in 4 Low- or Middle-Income Countries. [PDF]

, 2018
BackgroundWhether linear growth through age 12 y is associated with language and math achievement at age 12 y remains unclear.ObjectiveOur objective was to investigate associations of linear growth through age 12 y with reading skill, receptive ...
Adair, Alysse J Kowalski, Andreas Georgiadis, Aryeh D Stein, Barnett, Benjamin T Crookston, Casale, Casale, Cheung, Crookston, Crookston, Crookston, Cueto, Fink, Gandhi, Georgiadis, Georgiadis, Glewwe, Glewwe, Hoddinott, Hoddinott, Jere R Behrman, Kordas, Kuklina, Larson, Lia C H Fernald, Martorell, Mendez, Onis, Onis, Petrou, Prado, Sudfeld, Victora, Walker   +34 more
core   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Presenting Medieval Gambling and Pub Life

EXARC Journal, 2012
There are many legendary games in the Middle Ages with professed losses of clothes, horses and, what is more, whole estates, and even halves of kingdoms. But was money really the most important part of gambling?
Zsuzsanna Sőregi
doaj  

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Ранносредновековно селище до с. Драговищица, община Kостинброд

Приноси към българската археология, 2018
The article presents the results of the rescue archaeological excavations carried out at the medieval settlement found at site N 5. The settlement is situated to the south of the village of Dragovishtitsa, Kostinbrod municipality (Fig. 1).
Valeri Grigorov
doaj