Results 81 to 90 of about 156,557 (337)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Correction to: Relationship Between Body Temperature and Early Neurological Deterioration after Endovascular Thrombectomy for Acute Ischemic Stroke with Large Vessel Occlusion [PDF]

, 2022
Yaxi Luo, Man Chen, Jinghuan Fang, Shuju Dong, Mengmeng Ma, Jiajia Bao, Ling Feng, Li He   +7 more
openalex   +1 more source

The Ischemic Stroke Predictive Risk Score Predicts Early Neurological Deterioration

Journal of Stroke and Cerebrovascular Diseases, 2016
Although early neurological deterioration (END) during the acute stroke period is known to be directly associated with poor short- and long-term outcomes, few studies have investigated the ability to predict END. The aim of this study was to investigate whether there are differences in the occurrence of END according to the ischemic stroke predictive ...
Young Dae Kim, Hye-Yeon Choi, Yo Han Jung, Joonsang Yoo, Hyo Suk Nam, Dongbeom Song, Ji Hoe Heo, Gustavo Saposnik   +7 more
openaire   +3 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Prevalence and Risk Factors for Presumptive Ascending/Descending Myelomalacia in Dogs after Thoracolumbar Intervertebral Disk Herniation [PDF]

, 2017
Background: Ascending/descending myelomalacia (ADMM) is a severe complication of thoracolumbar intervertebral disk herniation (TL-IVDH) in dogs. Hypothesis/Objectives: To investigate the prevalence and risk factors for ADMM in nonambulatory dogs with ...
Aikawa, Amsellem, Bergknut, Bezuidenhout, Boekhoff, Ferreira, Fingeroth, Griffiths, Henke, Henke, Ito, Jeffery, Jeffery, Kato, Kranenburg, Lahunta, Laitinen, Levine, Lu, Marquis, Mayer, Muguet-Chanoit, Okada, Okada, Olby, Olby, Pais, Penning, Platt, Priester, Sato, Scott, Shinzato, Smolders, Zachary   +34 more
core   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Clinical significance of D-dimer levels during acute period in ischemic stroke

Thrombosis Journal, 2023
Background Initial D-dimer level is a well-known prognostic parameter in patients with acute ischemic stroke (AIS). However, there have been no studies on the clinical significance of follow-up D-dimer levels.
Ki-Woong Nam, Hyung-Min Kwon, Yong-Seok Lee   +2 more
doaj   +1 more source

Predictors of early neurological deterioration following intravenous thrombolysis: Difference between risk factors for ischemic and hemorrhagic worsening

Annals of Indian Academy of Neurology, 2022
Background: Prevention of early neurological deterioration (END) is becoming an important therapeutic target in acute ischemic stroke management. The aim of the study is to ascertain the causes and predictors of early neurological deterioration following
Srikumar B Nair, Deepthi Somarajan, Rammohan K Pillai, Keerthi Balachandran, Sona Sathian   +4 more
doaj   +1 more source

Role of brain perfusion SPECT with 99mTc HMPAO in the assessment of response to drug therapy in patients with autoimmune vasculitis: a prospective study [PDF]

, 2015
BACKGROUND: The diagnosis of vasculitis in the brain remains a quite difficult achievement. To the best of our knowledge, there is no imaging method reported in literature which is capable of reaching to a diagnosis of vasculitis with very high ...
Anna Margherita Maffione, 2, Christos, Anagnostou, CIVITELLI, Liana, COLLORONE, SARA, DRUDI, Francesco Maria, FRANCIA, Ada, LIBERATORE, Mauro, Maria Cristina Marzola, 3, MEGNA, VALENTINA, MORREALE, MANUELA, Rubello, Domenico, Sotirios Chondrogiannis, 2   +11 more
core   +1 more source

Neuroimaging Markers for Early Neurologic Deterioration in Single Small Subcortical Infarction [PDF]

Stroke, 2015
Background and Purpose— Early neurological deterioration (END) occurs in ≥20% of single small subcortical infarctions (SSSIs; axial diameter ≤20 mm in the perforator territories) and deters functional recovery. Both microvasculopathies and atherosclerosis have been proposed to independently contribute to the occurrence of END ...
Han-Gil, Jeong, Beom Joon, Kim, Mi Hwa, Yang, Moon-Ku, Han, Hee-Joon, Bae   +4 more
openaire   +2 more sources