Results 111 to 120 of about 648,849 (327)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

What happens when supercooling is terminated by curvature flipping of the effective potential?

Journal of High Energy Physics
We explore the nature of a certain type of supercooled phase transition, where the supercooling is guaranteed to end due to the curvature of the finite-temperature effective potential at the origin experiencing a sign flip at some temperature.
Tomasz P. Dutka, Tae Hyun Jung, Chang Sub Shin   +2 more
doaj   +1 more source

Super-slow phase transition catalyzed by BHs and the birth of baby BHs

Physics Letters B
We discuss the unique phenomenology of first-order phase transitions catalyzed by primordial black holes (BHs). If the number of BHs within one Hubble volume is smaller than unity at the time of bubble nucleation, each bubble catalyzed around them can ...
Ryusuke Jinno, Jun'ya Kume, Masaki Yamada   +2 more
doaj   +1 more source

Differential neutrino heating and reduced $^4$He production from decaying particles in the early universe [PDF]

, 1995
Richard E. Leonard, Robert J. Scherrer
openalex   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Bounds on the bubble wall velocity

Journal of High Energy Physics
Determining the bubble wall velocity in first-order phase transitions is a challenging task, requiring the solution of (coupled) equations of motion for the scalar field and Boltzmann equations for the particles in the plasma.
Wen-Yuan Ai, Benoit Laurent, Jorinde van de Vis   +2 more
doaj   +1 more source

Extracting gravitational waves induced by plasma turbulence in the early Universe through an averaging process [PDF]

, 2017
David Garrison, Christopher Ramirez
openalex   +1 more source

Spontaneous symmetry breaking in the late Universe and glimpses of the early Universe phase transitions à la baryogenesis [PDF]

, 2021
M. Sami, Radouane Gannouji
openalex   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source