Results 91 to 100 of about 647,754 (283)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Nearby primitive galaxies offer a window into the early universe. [PDF]

Proc Natl Acad Sci U S A, 2022
Croswell K.
europepmc   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Unitarity problems for an effective field theory description of early universe cosmology. [PDF]

Eur Phys J C Part Fields, 2022
Brandenberger R, Kamali V.
europepmc   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Early Universe Thermodynamics and Evolution in Nonviscous and Viscous Strong and Electroweak Epochs: Possible Analytical Solutions. [PDF]

Entropy (Basel), 2021
Tawfik AN, Greiner C.
europepmc   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

The Optically Thick Rotating Magnetic Wind from a Massive White Dwarf Merger Product. II. Axisymmetric Magnetohydrodynamic Simulations

The Astrophysical Journal
We numerically construct a series of axisymmetric rotating magnetic wind solutions, aiming at exploring the observation properties of massive white dwarf (WD) merger remnants with a strong magnetic field, a fast spin, and an intense mass loss, as ...
Yici Zhong, Kazumi Kashiyama, Shinsuke Takasao, Toshikazu Shigeyama, Kotaro Fujisawa   +4 more
doaj   +1 more source

Dynamics of HeHHe⁺ Rotational State Changes Induced by Collision with He: A Possible New Path in Early Universe Chemistry. [PDF]

J Phys Chem A, 2021
González-Sánchez L, Yurtsever E, Wester R, Gianturco FA.   +3 more
europepmc   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source