Results 91 to 100 of about 4,966,709 (244)

Our place in the Universe

, 2012
A Liverpool John Moores University public lecture podcast where Professor John Barrow reflects on Earth, the universe and our place within ...
Liverpool John Moores University, John Barrow   +1 more
core  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Neutrino oscillations at high densities: cosmological and astrophysical aspects [PDF]

, 2011
This doctoral thesis treats the effects of neutrino oscillations in the early universe and supernovae. The main probe for the context of the early universe is big bang nucleosynthesis (BBN).
Sarikas, Srdjan
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

The Optically Thick Rotating Magnetic Wind from a Massive White Dwarf Merger Product. II. Axisymmetric Magnetohydrodynamic Simulations

The Astrophysical Journal
We numerically construct a series of axisymmetric rotating magnetic wind solutions, aiming at exploring the observation properties of massive white dwarf (WD) merger remnants with a strong magnetic field, a fast spin, and an intense mass loss, as ...
Yici Zhong, Kazumi Kashiyama, Shinsuke Takasao, Toshikazu Shigeyama, Kotaro Fujisawa   +4 more
doaj   +1 more source

Super-slow phase transition catalyzed by BHs and the birth of baby BHs

Physics Letters B
We discuss the unique phenomenology of first-order phase transitions catalyzed by primordial black holes (BHs). If the number of BHs within one Hubble volume is smaller than unity at the time of bubble nucleation, each bubble catalyzed around them can ...
Ryusuke Jinno, Jun'ya Kume, Masaki Yamada   +2 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Thermalization effects on the dynamics of growing vacuum bubbles

Journal of High Energy Physics
We study the evolution of growing vacuum bubbles. The bubble walls interact with the surrounding fluid and may, consequently, reach a terminal velocity.
Tomasz Krajewski, Marek Lewicki, Martin Vasar, Ville Vaskonen, Hardi Veermäe, Mateusz Zych   +5 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source