Results 111 to 120 of about 647,754 (283)
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Particle shells from relativistic bubble walls
Journal of High Energy PhysicsRelativistic bubble walls from cosmological phase transitions (PT) necessarily accumulate expanding shells of particles. We systematically characterize shell properties, and identify and calculate the processes that prevent them from free streaming ...
Iason Baldes +3 more
doaj +1 more source
Super-slow phase transition catalyzed by BHs and the birth of baby BHs
Physics Letters BWe discuss the unique phenomenology of first-order phase transitions catalyzed by primordial black holes (BHs). If the number of BHs within one Hubble volume is smaller than unity at the time of bubble nucleation, each bubble catalyzed around them can ...
Ryusuke Jinno +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Thermalization effects on the dynamics of growing vacuum bubbles
Journal of High Energy PhysicsWe study the evolution of growing vacuum bubbles. The bubble walls interact with the surrounding fluid and may, consequently, reach a terminal velocity.
Tomasz Krajewski +5 more
doaj +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
What happens when supercooling is terminated by curvature flipping of the effective potential?
Journal of High Energy PhysicsWe explore the nature of a certain type of supercooled phase transition, where the supercooling is guaranteed to end due to the curvature of the finite-temperature effective potential at the origin experiencing a sign flip at some temperature.
Tomasz P. Dutka +2 more
doaj +1 more source